Chapter 8. Polymeric Nanoparticles and Cancer: Lessons Learnt from CRLX101

Gritli, Ismael; Garmey, Edward G.; Eliasof, Scott; Tellez, Andres; Davis, Mark E.; Yen, Yun

doi:10.1039/9781782622536-00199

Cited by 7 publications

(6 citation statements)

References 114 publications

(134 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is composed of β-CD-poly (ethylene glycol) copolymer conjugated to CPT which appeared to be safe and effective in phase 1/2 clinical studies. 115 Sugammadex is a selective relaxant binding agent with a modified γ-CD, and it is specifically designed to grab and encapsulate the aminosteroidal neuromuscular blocking agents such as rocuronium or vecuronium. Various clinical reports suggested the safety and efficacy of Sugammadex.…”

Section: Safety and Efficacy Aspects Of Cyclodextrin Nanoparticlesmentioning

confidence: 99%

Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics

Gadade

Pekamwar

2020

Adv Pharm Bull

View full text Add to dashboard Cite

Colloidal nanoparticulate technology has been described in the literature as a versatile drug delivery system. But it possesses some inherent lacunae in their formulation. Cyclodextrins (CDs) have been extensively reported for the solubility enhancement of poorly water-soluble drugs. The CDs can cause intervention in aspects related to nanoparticles (NPs) that include improving drug loading in nano-system, improving stability, site-specific/targeted drug delivery, improving solubility profile and absorption of the drug in nanosystem with consequent improvement in bioavailability, with the possibility of controlled release, safety and efficacy. They find application in for simultaneous diagnosis and therapeutics for better treatment procedures. The current communication is focused on the application of CDs to overcome troubles in nanoparticulate formulation and enhancement of their performance. It also envisages the theranostic aspects of CDs.

show abstract

Section: Safety and Efficacy Aspects Of Cyclodextrin Nanoparticlesmentioning

confidence: 99%

Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics

Gadade

Pekamwar

2020

Adv Pharm Bull

View full text Add to dashboard Cite

show abstract

“…Of note, EZN-2208 is a PEGylated prodrug loaded with SN-38 that showed prolonged circulation in various preclinical tumor xenograft models in comparison to free drug. PEG was attached in a manner that stabilized the drug, maintaining its active conformation (Gritli et al, 2016;Sapra et al, 2008). However, when given to patients with advanced CRC in a randomized clinical study, EZN-2208 did not demonstrate superior efficacy in terms of overall survival in comparison to Irinotecan (Garrett et al, 2013).…”

Section: The Mononuclear Phagocyte Systemmentioning

confidence: 99%

Critical considerations for targeting colorectal liver metastases with nanotechnology

Arshad

Sutton

Treacher³

et al. 2019

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

Colorectal cancer remains a significant cause of morbidity and mortality worldwide. Half of all patients develop liver metastases, presenting unique challenges for their treatment. The shortcomings of conventional chemotherapy has encouraged the use of nanomedicines; the application of nanotechnology in the diagnosis and treatment of disease. In spite of technological improvements in nanotechnology, the complexity of biological systems hinders the prospect of nanomedicines being applied in cancer therapy at the present time. This review highlights current biological barriers and discusses aspects of tumor biology together with the physicochemical features of the nanocarrier, that need to be considered in order to develop effective nanotherapeutics for colorectal cancer patients with liver metastases. It becomes clear that incorporating an interdisciplinary approach when developing nanomedicines should assure appropriate disease‐driven design and that this will form a critical step in improving their clinical translation. This article is characterized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

show abstract

“…Various CyD derivatives have been designed for many application fields [ 11 ] and for building nanomaterials, spanning from hybrid to organic nanosystems [ 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. Great interest is focused on the CyD-based polymers that can form water-soluble and stable NPs [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Hyaluronan-Cyclodextrin Conjugates as Doxorubicin Delivery Systems

et al. 2023

View full text Add to dashboard Cite

In the last years, nanoparticles based on cyclodextrins have been widely investigated for the delivery of anticancer drugs. In this work, we synthesized nanoparticles with a hyaluronic acid backbone functionalized with cyclodextrins under green conditions. We functionalized hyaluronic acid with two different molecular weights (about 11 kDa and 45 kDa) to compare their behavior as doxorubicin delivery systems. We found that the new hyaluronan-cyclodextrin conjugates increased the water solubility of doxorubicin. Moreover, we tested the antiproliferative activity of doxorubicin in the presence of the new cyclodextrin polymers in SK-N-SH and SK-N-SH-PMA (over-expressing CD44 receptor) cancer cells. We found that hyaluronan-cyclodextrin conjugates improved the uptake and antiproliferative activity of doxorubicin in the SK-N-SH-PMA compared to the SK-N-SH cell line at the ratio 8/1 doxorubicin/polymer. Notably, the system based on hyaluronan (45 kDa) was more effective as a drug carrier and significantly reduced the IC50 value of doxorubicin by about 56%. We also found that hyaluronic acid polymers determined an improved antiproliferative activity of doxorubicin (IC50 values are on average reduced by about 70% of free DOXO) in both cell lines at the ratio 16/1 doxorubicin/polymer.

show abstract

Chapter 8. Polymeric Nanoparticles and Cancer: Lessons Learnt from CRLX101

Cited by 7 publications

References 114 publications

Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics

Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics

Critical considerations for targeting colorectal liver metastases with nanotechnology

Hyaluronan-Cyclodextrin Conjugates as Doxorubicin Delivery Systems

Contact Info

Product

Resources

About