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citations
Cited by 6 publications
(4 citation statements)
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References 114 publications
(134 reference statements)
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“…It is composed of β-CD-poly (ethylene glycol) copolymer conjugated to CPT which appeared to be safe and effective in phase 1/2 clinical studies. 115 Sugammadex is a selective relaxant binding agent with a modified γ-CD, and it is specifically designed to grab and encapsulate the aminosteroidal neuromuscular blocking agents such as rocuronium or vecuronium. Various clinical reports suggested the safety and efficacy of Sugammadex.…”
Section: Safety and Efficacy Aspects Of Cyclodextrin Nanoparticlesmentioning
confidence: 99%
“…It is composed of β-CD-poly (ethylene glycol) copolymer conjugated to CPT which appeared to be safe and effective in phase 1/2 clinical studies. 115 Sugammadex is a selective relaxant binding agent with a modified γ-CD, and it is specifically designed to grab and encapsulate the aminosteroidal neuromuscular blocking agents such as rocuronium or vecuronium. Various clinical reports suggested the safety and efficacy of Sugammadex.…”
Section: Safety and Efficacy Aspects Of Cyclodextrin Nanoparticlesmentioning
confidence: 99%
“…Of note, EZN-2208 is a PEGylated prodrug loaded with SN-38 that showed prolonged circulation in various preclinical tumor xenograft models in comparison to free drug. PEG was attached in a manner that stabilized the drug, maintaining its active conformation (Gritli et al, 2016;Sapra et al, 2008). However, when given to patients with advanced CRC in a randomized clinical study, EZN-2208 did not demonstrate superior efficacy in terms of overall survival in comparison to Irinotecan (Garrett et al, 2013).…”
Section: The Mononuclear Phagocyte Systemmentioning
confidence: 99%
“…18,19 Some NPs based on CD polymers have also been synthesized and chemically modified for improving their properties. [20][21][22][23][24] Some metal ligands have also been covalently linked to CDbased NPs. [25][26][27][28] Terpyridine (tpy) is among the N-heterocycles with a very high binding affinity towards transition metal ions and this feature has been widely used to build supramolecular systems, mainly soluble in organic solvents.…”
mentioning
confidence: 99%
“…18,19 Some NPs based on CD polymers have also been synthesized and chemically modified for improving their properties. 20–24…”
mentioning
confidence: 99%