2020 DOI: 10.20944/preprints202009.0162.v1 View full text Preprint
Lei Lei, Zachary F. Burton

Abstract: The genetic code evolved by a combination of chaotic and ordered processes. Liquid-liquid phase separation (hydrogels), a chaotic process, constructs diverse membraneless compartments within cells, resulting in regulated hydration and sequestration and concentration of reaction components. Hydrogels relate to chaotic amyloid fiber production. We propose that polyglycine and related hydrogels (i.e. GADV; G is glycine), phase separations, membraneless droplets and amyloid accretions organized protocell domains t…

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