Changing pattern of antibiotic resistance of Helicobacter pylori in children during 20 years in Jinju, South Korea

Abstract

The antibiotic resistance rates of H. pylori in Jinju had a different pattern to other regions. The antibiotic resistance rates of H. pylori showed geographic variation, and local data should be provided as a guideline for treating H. pylori infection.

Quadruple Rescue erapy aer First and Second Line Failure for Helicobacter pylori Treatment: Comparison between Two Tetracycline-Based Regimens

“…Both drugs were approved by the Food and Drug Administration (FDA) [17] and by the European Medicines Agency (EMA), so they are available both in Europe and the United States [18]. Studies related to their use in Asian and African countries are also available [19][20][21][22].…”

Antibiotics resistance ofHelicobacter pyloriand treatment modalities in children withH. pyloriinfection

“…The range of clarithromycin resistance that has been reported for 10 countries varies widely, from 13.9% to 84.9% (Table 1), and is higher in 7 countries than the rate previously reported in 14 European countries (<24.0%)29). Moreover, an increasing tendency in the rate of clarithromycin resistance has been observed in Bulgaria17), South Korea22,24), Austria23), and Japan25). Presumably, this increase is due to the increased rate of prescription of clarithromycin for the treatment of respiratory tract infections in children.…”

“…In some countries, antimicrobial resistance has evolved with the use of antibacterial agents3,16). Table 1 shows recent the rates of H. pylori resistance to antimicrobials that are commonly administered to children in 10 countries17,18,19,20,21,22,23,24,25,26,27). The E-test has been established as a reliable modality for measuring antibiotic resistance to all antimicrobials, except for metronidazole for which it overestimates resistance.…”

“…Once administered orally, it is absorbed better and is more effective against H. pylori than other β-lactam antibiotics. According to a meta-analysis of 6 published studies, there have been no reports of amoxicillin resistance (Table 1)20,21,23,24,25,27). In contrast, 2 South Korean studies reported a great discrepancy in the rate of amoxicillin resistance between the 2 main regional areas, with Seoul reported to have a rate of 0% and Jinju, of 24.2%22,24).…”

Helicobacter pylori Gastritis: Susceptible to Further Testing?

“…In a Vietnamese study, clarithromycin resistance, which exceeded 50 % in young children, was a significant cause of treatment failure. The authors suggested that clarithromycin should not be used as part of H. pylori eradication therapy in children if their antibiotic susceptibility profile is unknown [7][8][9][10]. The conclusions of the authors from these aforementioned studies reflect a distinct change in the approach to management of H. pylori infection, which is targeted therapy based on resistance profiles, rather than the disease outcomes.…”