Changing Incidence of Inflammatory Bowel Disease: Environmental Influences and Lessons Learnt from the South Asian Population

Foster, Alice; Jacobson, Kevan

doi:10.3389/fped.2013.00034

Cited by 29 publications

(26 citation statements)

References 87 publications

(96 reference statements)

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“…It is clear that Indians and other South Asians do not lack the genetic background necessary for development of IBD. Studies in South Asian migrants to the United Kingdom and North America indicate that incidence and prevalence of IBD in second generation migrants approaches or exceeds that in the local population [5] – [7] .…”

Section: Introductionmentioning

confidence: 99%

Protective Association of Tumor Necrosis Factor Superfamily 15 (TNFSF15) Polymorphic Haplotype with Ulcerative Colitis and Crohn's Disease in an Indian Population

2014

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BackgroundTumor necrosis factor superfamily (TNFSF) proteins are involved in the genesis of inflammatory bowel disease (IBD). We examined the association of seven single nucleotide polymorphisms (SNP) in the TNFSF15 gene with Crohn's disease (CD) and ulcerative colitis (UC) in the Indian population.MethodsSeven SNPs in the TNFSF15 gene (rs10114470, rs3810936, rs6478108, rs4263839, rs6478109, rs7848647 and rs7869487) were genotyped in 309 CD patients, 330 UC patients and 437 healthy controls using the Sequenom iPLEX MassArray platform. Disease associations were evaluated for allelotypes and for genotypes.ResultsThe minor T alleles and the TT genotypes of rs10114470 and rs3810936 were significantly protectively associated with both CD and UC. The CC genotype of rs6478108, AA genotype of rs4263839, the AA genotype of rs6478109, the TT genotype of rs7848647 and the CC genotype of rs7869487 were all protectively associated with CD but not with UC. Two haplotype blocks could be discerned, one where SNPs rs10114470 and rs3810936 were in tight LD (D′ = 0.8) and the other where rs6478108, rs4263839, rs6478109, rs7848647 and rs7869487 were in tight LD (D′ 0.92–1.00). The second block of haplotypes were not associated with CD or with UC. The first block of haplotypes was very significantly associated with both CD and UC.ConclusionsStrong associations exist between TNFSF15 gene polymorphisms and IBD (both CD and UC) in the Indian population.

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Section: Introductionmentioning

confidence: 99%

Protective Association of Tumor Necrosis Factor Superfamily 15 (TNFSF15) Polymorphic Haplotype with Ulcerative Colitis and Crohn's Disease in an Indian Population

2014

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“…Numerous studies have evaluated the different environmental exposures during childhood, albeit findings for many have been inconsistent [ 4 – 14 ]. These inconsistencies may be attributed to differences in both the timing and the extent of the various environmental exposures during childhood, as well as the heterogeneity in CD susceptibility mutations both between and within individual population groups [ 15 , 16 ]. Alternatively, these findings may be a result of methodological issues such as study sample size, participant characteristics (i.e.…”

Section: Introductionmentioning

confidence: 99%

The association between environmental exposures during childhood and the subsequent development of Crohn’s disease: A score analysis approach

et al. 2017

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BackgroundEnvironmental factors during childhood are thought to play a role in the aetiology of Crohn’s Disease (CD). In South Africa, recently published work based on an investigation of 14 childhood environmental exposures during 3 age intervals (0–5, 6–10 and 11–18 years) has provided insight into the role of timing of exposure in the future development of CD. The ‘overlapping’ contribution of the investigated variables however, remains unclear. The aim of this study was to perform a post hoc analysis using this data and investigate the extent to which each variable contributes to the subsequent development of CD relative to each aforementioned age interval, based on a score analysis approach.MethodsThree methods were used for the score analysis. Two methods employed the subgrouping of one or more (similar) variables (methods A and B), with each subgroup assigned a score value weighting equal to one. For comparison, the third approach (method 0) involved no grouping of the 14 variables. Thus, each variable held a score value of one.ResultsResults of the score analysis (Method 0) for the environmental exposures during 3 age intervals (0–5, 6–10 and 11–18 years) revealed no significant difference between the case and control groups. By contrast, results from Method A and Method B revealed a significant difference during all 3 age intervals between the case and control groups, with cases having significantly lower exposure scores (approximately 30% and 40% lower, respectively).ConclusionResults from the score analysis provide insight into the ‘compound’ effects from multiple environmental exposures in the aetiology of CD.

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“…Nonetheless, the incidence and prevalence of IBD have more recently been rising in Asia and the Middle East, and individuals from these geographic regions experience an increased risk of developing IBD when immigrating to North America or Europe (Benchimol 2015;Pinsk 2007). This overall increase in IBD among populations not traditionally associated with IBD has been hypothesized to stem from the Westernization of lifestyles and diets (Foster 2013;Ooi 2016). For example, immigrants from Latin American to South Florida develop IBD at a later age; however, first-generation US-born Hispanics develop IBD at an age similar to non-Hispanic whites (Damas 2013).…”

Section: Description Of the Conditionmentioning

confidence: 99%

Dietary interventions for induction and maintenance of remission in inflammatory bowel disease

Limketkai

Iheozor‐Ejiofor

Gjuladin-Hellon

et al. 2019

Cochrane Database of Systematic Reviews

105

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Analysis 2.4. Comparison 2 Intervention diet versus control diet in inactive Crohn's disease, Outcome 4 Need for surgery......... Analysis 2.5. Comparison 2 Intervention diet versus control diet in inactive Crohn's disease, Outcome 5 Disease progression...... Analysis 2.6. Comparison 2 Intervention diet versus control diet in inactive Crohn's disease, Outcome 6 Escalation of therapy..... Analysis 2.7. Comparison 2 Intervention diet versus control diet in inactive Crohn's disease, Outcome 7 Withdrawals due to adverse events.

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Changing Incidence of Inflammatory Bowel Disease: Environmental Influences and Lessons Learnt from the South Asian Population

Cited by 29 publications

References 87 publications

Protective Association of Tumor Necrosis Factor Superfamily 15 (TNFSF15) Polymorphic Haplotype with Ulcerative Colitis and Crohn's Disease in an Indian Population

Protective Association of Tumor Necrosis Factor Superfamily 15 (TNFSF15) Polymorphic Haplotype with Ulcerative Colitis and Crohn's Disease in an Indian Population

The association between environmental exposures during childhood and the subsequent development of Crohn’s disease: A score analysis approach

Dietary interventions for induction and maintenance of remission in inflammatory bowel disease

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