Changing handedness: What can we learn from preference shift studies?

Marcori, Alexandre Jehan; Monteiro, Pedro Henrique Martins; Okazaki, Victor Hugo Alves

doi:10.1016/j.neubiorev.2019.09.019

Cited by 37 publications

(20 citation statements)

References 50 publications

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“…The phenotypic plasticity supports the notion of bidirectional influence across ontogeny—the neural traits influencing handedness and vice versa. This reciprocity is supported by studies showing that handedness shifts can modulate brain asymmetries (Marcori and Okazaki 2020; Marcori and others 2019; Sun and others 2012) but also by studies reporting that lesions altering brain structure can produce shifts in hand selection (Howells and others 2020). It is in light of such bidirectionality that discussion on the brain asymmetries and handedness should be viewed.…”

Section: Introductionmentioning

confidence: 79%

Handedness and White Matter Networks

2020

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The development and persistence of laterality is a key feature of human motor behavior, with the asymmetry of hand use being the most prominent. The idea that asymmetrical functions of the hands reflect asymmetries in terms of structural and functional brain organization has been tested many times. However, despite advances in laterality research and increased understanding of this population-level bias, the neural basis of handedness remains elusive. Recent developments in diffusion magnetic resonance imaging enabled the exploration of lateralized motor behavior also in terms of white matter and connectional neuroanatomy. Despite incomplete and partly inconsistent evidence, structural connectivity of both intrahemispheric and interhemispheric white matter seems to differ between left and right-handers. Handedness was related to asymmetry of intrahemispheric pathways important for visuomotor and visuospatial processing (superior longitudinal fasciculus), but not to projection tracts supporting motor execution (corticospinal tract). Moreover, the interindividual variability of the main commissural pathway corpus callosum seems to be associated with handedness. The review highlights the importance of exploring new avenues for the study of handedness and presents the latest state of knowledge that can be used to guide future neuroscientific and genetic research.

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Section: Introductionmentioning

confidence: 79%

Handedness and White Matter Networks

2020

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“…Ambidextrous subjects of both sexes showed higher HGS of the right hand (significant only in the male sex). This latter trend is likely due to the greater pressure of our society to use the right hand in various occupational tasks from childhood on [47,80,81].…”

Section: Discussionmentioning

confidence: 99%

Handgrip Strength in Young Adults: Association with Anthropometric Variables and Laterality

Zaccagni

Toselli

Bramanti

et al. 2020

IJERPH

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The measurement of handgrip strength (HGS) is an indicator of an individual’s overall strength and can serve as a predictor of morbidity and mortality. This study aims to investigate whether HGS is associated with handedness in young adults and if it is influenced by anthropometric characteristics, body composition, and sport-related parameters. We conducted a cross-sectional study on a sample of 544 young Italian adults aged 18–30 years. We measured HGS using a dynamometer and collected data on handedness and physical activity, along with anthropometric measurements. In both sexes, the HGS of the dominant side was significantly greater than that of the non-dominant side. Furthermore, in ambidextrous individuals, the right hand was stronger than the left. A comparison between the lowest and the highest tercile of HGS highlighted its significant association with anthropometric and body composition parameters in both sexes. Moreover, sex, dominant upper arm muscle area, arm fat index, fat mass, and fat-free mass were found to be significant predictors of HGS by multiple regression analysis. Our findings suggest that HGS is especially influenced by body composition parameters and handedness category. Therefore, HGS can be used as a proxy for unhealthy conditions with impairment of muscle mass, provided that the dominance in the laterality of the subject under examination is taken into account.

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“…According to the International Classification of Headache Disorders, Third Edition (beta version) (ICHD-3 beta) [23], 30 patients with MwoA(4 with chronic migraine, and 26 with episodic migraine) and 22 healthy controls were recruited in the study between May 2018 and June 2019. All subjects were right-handed [24].…”

Section: Methodsmentioning

confidence: 99%

Altered functional connectivity of the red nucleus and substantia nigra in migraine without aura

et al. 2019

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Background: Functional connectivity (FC) has been used to investigate the pathophysiology of migraine. Accumulating evidence is pointing toward malfunctioning of brainstem structures, i.e., the red nucleus (RN) and substantia nigra (SN), as an important factor in migraine without aura (MwoA). We aimed to identify atypical FC between the RN and SN and other brain areas in patients with MwoA and to explore the association between RN and SN connectivity changes and performance on neuropsychological tests in these patients. Methods: Resting-state functional magnetic resonance imaging (fMRI) data were obtained from 30 patients with MwoA and 22 age-, sex-, and years of education-matched healthy controls (HC). The FC of the brainstem structures was analyzed using a standard seed-based whole-brain correlation method. The results of the brainstem structure FC were assessed for correlations with other clinical features. Results: Patients with MwoA exhibited reduced left RN-based FC with the left middle frontal gyrus, reduced right RNbased FC with the ipsilateral superior parietal lobe, and increased FC with the ipsilateral cerebellum. Additionally, patients with MwoA demonstrated significantly decreased right SN-based FC with the right postcentral gyrus, left parietal lobule, and left superior frontal gyrus. Hypo-connectivity between the right SN and right postcentral gyrus was negatively correlated with disease duration (r = − 0.506, P = 0.004). Additionally, increased connectivity of the right RN to the ipsilateral cerebellar lobes was positively correlated with the Headache Impact Test-6 scores (r = 0.437, P = 0.016). Conclusions: The present study suggested that patients with MwoA have disruption in their RN and SN resting-state networks, which are associated with specific clinical characteristics. The changes focus on the regions associated with cognitive evaluation, multisensory integration, and modulation of perception and pain, which may be associated with migraine production, feedback, and development. Taken together, these results may improve our understanding of the neuropathological mechanism of migraine.

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Changing handedness: What can we learn from preference shift studies?

Cited by 37 publications

References 50 publications

Handedness and White Matter Networks

Handedness and White Matter Networks

Handgrip Strength in Young Adults: Association with Anthropometric Variables and Laterality

Altered functional connectivity of the red nucleus and substantia nigra in migraine without aura

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