Changing epidemiology of hepatocellular carcinoma in Asia

Zhang, Chen-Hao; Cheng, Yifei; Zhang, Shu; Fan, Jia; Gao, Qiang

doi:10.1111/liv.15251

Cited by 181 publications

(138 citation statements)

References 116 publications

(208 reference statements)

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“…HBV positive patients accounted for 70.42% [ 31 ]. Despite data showing that the incidence of HCV-related HCC in Asia has been decreasing since 2006, the potential risk of HCV infection cannot be ignored [ 5 ].…”

Section: Viral Hepatitis-related Hccmentioning

confidence: 99%

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Changes in the Epidemiology of Hepatocellular Carcinoma in Asia

Liu

2022

Cancers

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Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, with high morbidity and mortality, and the incidence is on the rise. HCC imposes a heavy healthcare burden on Asian countries due to the presence of multiple HCC risk factors in this area. Chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, non-alcoholic liver disease (NAFLD), aflatoxin and alcohol intake are the causes of HCC that cannot be ignored. Compared with the pre-vaccination era, universal vaccination of newborns reduces the incidence of HCC. Anti-viral therapy with nucleos(t)ide analogues also causes a decline in HCC incidence. Early screening and direct-acting antiviral agent are beneficial to the prevention and treatment of HCV. For HCC caused by NAFLD and other reasons, lifestyle changes are imperative. This paper introduces the epidemiological trends of HCC in Asia and highlight future efforts. Focusing on prevention may be the most effective way to improve the prognosis of this hard-to-treat cancer.

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Section: Viral Hepatitis-related Hccmentioning

confidence: 99%

“…Moreover, GLOBOCAN 2020 shows a worrying trend that the incidence of liver cancer in many countries increasing significantly in recent years, including Iran, Afghanistan, Qatar, Azerbaijan, Iraq, and Nepal. Local governments should pay attention to this rising trend to avoid a large-scale epidemic of liver cancer [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Changes in the Epidemiology of Hepatocellular Carcinoma in Asia

Liu

2022

Cancers

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“…Zhang et al reviewed the changing epidemiology of hepatocellular carcinoma (HCC) in Asia, focusing on the demographic characteristics, risk factors, as well as prevention and surveillance of HCC 12 . HBV and HCV remain the most common risk factors with a slightly downward trend in most Asian countries.…”

Section: Hepatocellular Carcinomamentioning

confidence: 99%

The changing epidemiology of liver diseases in Asia

Sun

Tanaka

Valenti

2022

Liver International

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“…Primary liver cancer is the sixth most frequently diagnosed cancer and the third most lethal cancer, with approximately 906,000 new cases and 830,000 deaths worldwide. 1 The incidence of liver cancer is increasing all over the world. 2 , 3 It is estimated that by 2025, more than 1 million people worldwide will be affected by liver cancer every year.…”

Section: Introductionmentioning

confidence: 99%

“… 4 The annual incidence of HCC in persons with HCV-related cirrhosis ranges from 0.5–10%. 1 Between 10% and 20% of HCC cases in the USA are now attributed to Non-alcoholic fatty liver disease (NAFLD). 5 The trends of alcohol use and alcoholic liver disease vary among countries.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of Combined Detection via Protein Induced by Vitamin K Absence or Antagonist II, Alpha-Fetoprotein, and D-Dimer in Hepatitis B Virus-Related Hepatocellular Carcinoma

Peng¹,

Yuan²,

Zhou³

et al. 2022

IJGM

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Purpose We aimed to explore the clinical diagnostic value of combined detection via protein induced by vitamin K absence or antagonist II (PIVKA-II), alpha-fetoprotein (AFP), and D-dimer (D-D) in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Materials and Methods We analyzed PIVKA-II, AFP, and D-D levels in 291 subjects comprising liver cirrhosis (LC) patients (n = 143) and HCC patients (n = 148). Receiver operating characteristic (ROC) curves were used to analyze and compare the clinical diagnostic value of the three biomarkers for HBV-related HCC alone and in combination. Results The levels of PIVKA-II, AFP, and D-D were positively correlated with tumor size in HCC patients. The levels of PIVKA-II and AFP in early-stage HCC, advanced HCC, HBV DNA+ HCC, and HBV DNA- HCC patients were higher than those in LC patients, while the levels of D-D were lower. The area under the curve for combined detection was greater than that for single-index detection in early-stage HCC, advanced HCC, HBV DNA+ HCC, and HBV DNA- HCC patients. Conclusion D-D may be a useful biomarker for the diagnosis of HBV-related HCC. The combined detection of PIVKA-II, AFP, and D-D had better diagnostic value for different types of HCC than the detection of individual biomarkers.

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Changing epidemiology of hepatocellular carcinoma in Asia

Cited by 181 publications

References 116 publications

Changes in the Epidemiology of Hepatocellular Carcinoma in Asia

Changes in the Epidemiology of Hepatocellular Carcinoma in Asia

The changing epidemiology of liver diseases in Asia

Diagnostic Value of Combined Detection via Protein Induced by Vitamin K Absence or Antagonist II, Alpha-Fetoprotein, and D-Dimer in Hepatitis B Virus-Related Hepatocellular Carcinoma

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