Changes of serum Mir-217 and the correlation with the severity in type 2 diabetes patients with different stages of diabetic kidney disease

Shao, Ying; Ren, Huiwen; Lv, Chuan; Ma, Xiaoyu; Wu, Can; Wang, Qiuyue

doi:10.1007/s12020-016-1069-4

Cited by 47 publications

(31 citation statements)

References 34 publications

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“…Moreover, there was a significant association between Ln (albumin/creatinine ratio) with SIRT1 and miR-217 ( P < 0.05). [18] In another study by Fathy et al ., serum SIRT1 levels were significantly lower in the normoalbuminuric group ( P < 0.05). SIRT1 demonstrated a positive correlation with FBG in normoalbuminuric patients ( P < 0.05) and also a negative correlation with microalbumin in macroalbuminuric patients ( P < 0.05).…”

Section: Discussionmentioning

confidence: 99%

Serum sirtuin 1 protein as a potential biomarker for type 2 diabetes: Increased expression of sirtuin 1 and the correlation with microRNAs

et al. 2019

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Background: Type 2 diabetes (T2DM) is characterized by hyperglycemia and insulin deficiency. Sirtuin 1 (SIRT1), serving as a deacetylase, is critical in the regulation of glucose and lipid metabolism. Recently, a number of studies have been conducted to investigate the role of SIRT1 in the pathogenesis of T2DM. However, there are no sufficient data about the relationship between SIRT1 and T2DM. The aim of this study was to analyze the expressions of microRNAs (miRNAs) (miR-34a, miR-9, miR-132, and miR-181a) involved in SIRT1 regulation and SIRT1 protein in the serum of T2DM patients and controls. Materials and Methods: miRNA expressions were determined by real-time polymerase chain reaction, and enzyme-linked immunosorbent assay was used to measure the SIRT1 protein levels in 25 T2DM patients and 25 controls. Results: Fasting blood glucose and glycated hemoglobin levels were significantly higher in patients when compared with controls ( P < 0.001). There was no difference for miRNA expressions between the groups ( P > 0.05). SIRT1 protein level was significantly increased in patients as compared to controls ( P = 0.044). Moreover, SIRT1 was negatively correlated with miR-181a ( r = −0.558, P = 0.005) and miR-132 ( r = −0.435, P = 0.034) in patients. Conclusion: Obtained results indicate that serum SIRT1 may be a potentially new biomarker for T2DM and also miR-181a and miR-132 may be involved in the development of T2DM by targeting SIRT1. This is the first study reporting on the effects of SIRT1 and related miRNAs in Turkish T2DM patients.

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Section: Discussionmentioning

confidence: 99%

Serum sirtuin 1 protein as a potential biomarker for type 2 diabetes: Increased expression of sirtuin 1 and the correlation with microRNAs

et al. 2019

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“…It has been reported that high glucose inhibited H 2 S production via TLR4 inflammatory pathway in mouse mesangial cells [28]. In addition, the expression of several microRNAs, including miR-192 [29], miR-204 [30], and miR-217 [31], was upregulated by high glucose. According to bioinformatic analysis on the website of “TargetScan,” the predicted target gene of miR-192 and miR-204 is CSE and the predicted target gene of miR-217 is CBS.…”

Section: Discussionmentioning

confidence: 99%

Hydrogen Sulfide Inhibits High Glucose-Induced sFlt-1 Production via Decreasing ADAM17 Expression in 3T3-L1 Adipocytes

Wang

et al. 2017

International Journal of Endocrinology

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Hydrogen sulfide (H 2 S) has recently been identified as an endogenous gaseous signaling molecule. The aim of the present study was to investigate the effect of H 2 S on high glucose-(HG-) induced ADAM17 expression and sFlt-1 production in 3T3-L1 adipocytes. Firstly, we found that HG DMEM upregulated the expression of ADAM17 and production of sFlt-1 in 3T3-L1 adipocytes. Knocking down ADAM17 attenuated the effect of high glucose on sFlt-1 production in adipocytes. HG decreased the expression of CSE and 3-MST, as well as the endogenous H 2 S production. Furthermore, knocking down CSE and 3-MST significantly increased ADAM17 expression and sFlt-1 production. The addition of exogenous H 2 S through the administration of sodium hydrosulfide (NaHS) inhibited HG-induced upregulation of ADAM17 expression and sFlt-1 production. In conclusion, decreased expression of CSE and 3-MST and the subsequent decrease in H 2 S production contribute to high glucose-induced sFlt-1 production via activating ADAM17 in adipocytes. Exogenous H 2 S donor NaHS has a potential therapeutic value for diabetic vascular complications.

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“…Another clinical study showed that miR-217 closely correlates with the severity of DN in patients with T2DM. Serum miR-217 levels positively correlate with the severity of albuminuria and negatively correlate with sirtuin-1 expression in patients with T2DM [19]. In addition, the study by Shao et al showed that miR-217 expression increases in HG-treated rat GMCs.…”

Section: Endogenous Factors Regulate Sirtuin-1 In Diabetic Nephropathymentioning

confidence: 99%

Role of sirtuin-1 in diabetic nephropathy

et al. 2019

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Diabetic nephropathy (DN) is a research priority for scientists around the world because of its high prevalence and poor prognosis. Although several mechanisms have been shown to be involved in its pathogenesis and many useful drugs have been developed, the management of DN remains challenging. Increasing amounts of evidence show that silent information regulator 2 homolog 1 (sirtuin-1), a nicotinamide adenine dinucleotide (NAD+)–dependent protein deacetylase, plays a crucial role in the pathogenesis and development of DN. Clinical data show that gene polymorphisms of sirtuin-1 affect patient vulnerability to DN. In addition, upregulation of sirtuin-1 attenuates DN in various experimental models of diabetes and in renal cells, including podocytes, mesangial cells, and renal proximal tubular cells, incubated with high concentrations of glucose or advanced glycation end products. Mechanistically, sirtuin-1 has its renoprotective effects by modulating metabolic homeostasis and autophagy, resisting apoptosis and oxidative stress, and inhibiting inflammation through deacetylation of histones and the transcription factors p53, forkhead box group O, nuclear factor-κB, hypoxia-inducible factor-1α, and others. Furthermore, some microRNAs have been implicated in the progression of DN because they target sirtuin-1 mRNA. Several synthetic drugs and natural compounds have been identified that upregulate the expression and activity of sirtuin-1, which protects against DN. The present review will summarize advances in knowledge regarding the role of sirtuin-1 in the pathogenesis of DN. The available evidence implies that sirtuin-1 has great potential as a clinical target for the prevention and treatment of diabetes.

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Changes of serum Mir-217 and the correlation with the severity in type 2 diabetes patients with different stages of diabetic kidney disease

Cited by 47 publications

References 34 publications

Serum sirtuin 1 protein as a potential biomarker for type 2 diabetes: Increased expression of sirtuin 1 and the correlation with microRNAs

Serum sirtuin 1 protein as a potential biomarker for type 2 diabetes: Increased expression of sirtuin 1 and the correlation with microRNAs

Hydrogen Sulfide Inhibits High Glucose-Induced sFlt-1 Production via Decreasing ADAM17 Expression in 3T3-L1 Adipocytes

Role of sirtuin-1 in diabetic nephropathy

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