Changes of pro-inflammatory and anti-inflammatory macrophages after peripheral nerve injury

Zhang, Fuchao; Miao, Yang; Liu, Qianyan; Li, Shiying; He, Jianghong

doi:10.1039/d0ra06607a

Cited by 15 publications

(13 citation statements)

References 41 publications

(43 reference statements)

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“…[44] In vivo implantation of M2 macrophages promoted SCs migration and stimulated SCs infiltration through miRNAs carried in microvesicles, which both favor axon regeneration. [35] Conversely, implantation of M1 macrophages did not show similar beneficial effects. [35,58,61] Therefore, M2 macrophages not only affect the SCs but also affect nerve repair.…”

Section: Mids Facilitate Microenvironment Reconstruction By Scs and M...mentioning

confidence: 96%

“…[35] Conversely, implantation of M1 macrophages did not show similar beneficial effects. [35,58,61] Therefore, M2 macrophages not only affect the SCs but also affect nerve repair. We confirmed that macrophage aggregation enhanced the proliferation and migration of SCs to some extent.…”

Section: Mids Facilitate Microenvironment Reconstruction By Scs and M...mentioning

confidence: 96%

“…It is reported that macrophages play a critical role in PNS injury and repair. [35] Following PNI, a large number of macrophages are recruited to the sites of injury, where they contribute to WD and also receive signals from the changing local microenvironment to polarize into a pro-healing M2 phenotype, thus enhancing axon regeneration. [9,36] Therefore, precise regulation of the polarization of macrophages is critical when constructing bioactive materials in nerve tissue engineering.…”

Section: Mids Facilitate M1 To M2 Macrophage Polarization After Injurymentioning

confidence: 99%

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Modulation of the Crosstalk between Schwann Cells and Macrophages for Nerve Regeneration: A Therapeutic Strategy Based on a Multifunctional Tetrahedral Framework Nucleic Acids System

Yao

Wang

et al. 2022

Advanced Materials

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Peripheral nerve injury (PNI) is currently recognized as one of the most significant public health issues and affects the general well‐being of millions of individuals worldwide. Despite advances in nerve tissue engineering, nerve repair still cannot guarantee complete functional recovery. In the present study, an innovative approach is adopted to establish a multifunctional tetrahedral framework nucleic acids (tFNAs) system, denoted as MiDs, which can integrate the powerful programmability, permeability, and structural stability of tFNAs, with the nerve regeneration potential of microRNA‐22 to enhance the communication between Schwann cells (SCs) and macrophages for more effective functional rehabilitation of peripheral nerves. Relevant results demonstrate that MiDs can amplify the ability of SCs to recruit macrophages and facilitate their polarization into the pro‐healing M2 phenotype to reconstruct the post‐injury microenvironment. Furthermore, MiDs can initiate the adaptive intracellular reprogramming of SCs within a short period to further promote axon regeneration and remyelination. MiDs represent a new possibility for enhancing nerve repair and may have critical clinical applications in the future.

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Section: Mids Facilitate Microenvironment Reconstruction By Scs and M...mentioning

confidence: 96%

Section: Mids Facilitate Microenvironment Reconstruction By Scs and M...mentioning

confidence: 96%

Section: Mids Facilitate M1 To M2 Macrophage Polarization After Injurymentioning

confidence: 99%

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Modulation of the Crosstalk between Schwann Cells and Macrophages for Nerve Regeneration: A Therapeutic Strategy Based on a Multifunctional Tetrahedral Framework Nucleic Acids System

Yao

Wang

et al. 2022

Advanced Materials

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“…These reactions lead to a significant decrease in the number of new central nuclear myotubes and in the volume of regenerated muscle fibers, leading to necrosis sexual muscle fibers while inflammatory cell infiltration increased significantly. Research by Zhang et al (2020a) ; Zhang et al (2020b) showed that endothelial cells initiate lactate shuttle through glycolysis products during ischemia, which polarizes macrophages to M2 type and secretes a large amount of VEGF, which strengthens the positive feedback loop of angiogenesis, improves the density of angiogenesis, and promotes muscle revascularization. In addition, VEGF can also contribute to the muscle regeneration by inducing the proliferation and differentiation of myogenic progenitor cells of skeletal muscle.…”

Section: Macrophages and Tissue Regenerationmentioning

confidence: 99%

“…Previous studies have mostly focused on the observation and description of the phenotype, morphology, and mechanism of macrophages that promote tissue damage by inducing an immune response ( Rayees et al, 2020 ; Zhang et al, 2020a ; Zhang et al, 2020b ; Li et al, 2021a ; Li et al, 2021b ). With the gradual development of regenerative medicine and modern molecular biology, recent studies have found that macrophages play an important role in promoting the regeneration of different tissues such as the heart, liver, kidney, muscle, and nerve.…”

Section: Introductionmentioning

confidence: 99%

Macrophages play a key role in tissue repair and regeneration

Yue

et al. 2022

PeerJ

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Tissue regeneration after body injury has always been a complex problem to resolve for mammals. In adult mammals, the repair process after tissue injury is often accompanied by continuous and extensive fibrosis, which leads to scars. This process has been shown to severely hinder regeneration. Macrophages, as widely distributed innate immune cells, not only play an important role in various pathological processes, but also participate in the repair process before tissue regeneration and coordinate the regeneration process after repair. This review will discuss the various forms and indispensability of macrophages involved in repair and regeneration, and how macrophages play a role in the repair and regeneration of different tissues.

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Investigation of Stem Cell‐Like Characteristics and Immune Cell Interaction of Tumor Cells Survived from Continuous Shear Flow Environment

Huang,

Pai,

Lei

2023

Advanced Biology

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When tumor cells are released from a primary tumor into the bloodstream or lymphatic circulation system, they are exposed to a continuous shear flow environment. This environment exerts physical stresses on the tumor cells, which can activate apoptotic pathways. However, certain tumor cells have the ability to adapt to these mechanical stresses, enhancing their likelihood of survival and promoting metastasis. In this study, these tumor cells survived from shear flow environment are examined and revealed to closely link to stem cell‐like characteristics. Higher gene expression levels of self‐renewal and differentiation markers and enhanced abilities of migration, spheroid formation, and colony formation are shown. Moreover, the interaction between immune cells and the surviving cells is investigated. The results show that the surviving cells possess immune escape capabilities, implying their ability to evade immune surveillance. Additionally, these surviving cells display characteristics reminiscent of stem cells. This study holds great importance in advancing the understanding of tumor biology. By comprehending the behavior and properties of these surviving cells, new therapeutic strategies can be developed to specifically target circulating tumor cells (CTCs) and enhance cancer treatment outcomes.

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Changes of pro-inflammatory and anti-inflammatory macrophages after peripheral nerve injury

Abstract: The temporal patterns of pro-inflammatory and anti-inflammatory macrophages after peripheral nerve injury.

Cited by 15 publications

References 41 publications

Modulation of the Crosstalk between Schwann Cells and Macrophages for Nerve Regeneration: A Therapeutic Strategy Based on a Multifunctional Tetrahedral Framework Nucleic Acids System

Modulation of the Crosstalk between Schwann Cells and Macrophages for Nerve Regeneration: A Therapeutic Strategy Based on a Multifunctional Tetrahedral Framework Nucleic Acids System

Macrophages play a key role in tissue repair and regeneration

Investigation of Stem Cell‐Like Characteristics and Immune Cell Interaction of Tumor Cells Survived from Continuous Shear Flow Environment

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