Changes of MMP-1 and collagen type Iα1 by UVA, UVB and IRA are differentially regulated by Trx-1

Buechner, Nicole; Schröeder, Peter; Jakob, Sascha; Kunze, Kerstin; Maresch, Tanja; Calles, Christian; Krutmann, Jean; Haendeler, Judith

doi:10.1016/j.exger.2008.04.009

Cited by 86 publications

(65 citation statements)

References 21 publications

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“…These results were consistent with published studies using higher IRA irradiances and different doses, showing that IRA induced a downmodulation of type I collagen, fibrillin and fibronectin and an upmodulation of MMP1 [14,22,26,27]. Few or no results were reported on the modulation of other matrix components or other proteases.…”

Section: Resultssupporting

confidence: 81%

“…Other studies have shown the implication of IRA in photoaging [13,20], with modifications of extracellular matrix component expression, such as a decrease in type I collagen expression and an increase in matrix metalloproteinase-1 (MMP1), both in vitro on normal fibroblasts and in vivo on normal human skin [12,14,21,22]. These parameter changes might contribute to the induction of wrinkles [23].…”

Section: Introductionmentioning

confidence: 99%

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Low to Moderate Doses of Infrared A Irradiation Impair Extracellular Matrix Homeostasis of the Skin and Contribute to Skin Photodamage

Robert

Bonnet²,

Marques³

et al. 2015

Skin Pharmacol Physiol

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Human skin is daily exposed to sun rays, which include not only ultraviolet radiation, but also an important quantity of infrared (IR) radiation. In the past few years, many publications have underlined the negative impact of IR radiation on the human skin, particularly when the skin and/or the cells are exposed to high sun irradiance and significant doses of IR. In the present study, we demonstrate, in vitro on normal human fibroblasts, that even under low irradiance with single or very few repeated doses, infrared A irradiation (IRA) produces free radicals, triggers major changes in the expression of the type I collagen and elastin network, impairs the dermal-epidermal junction, upregulates several matrix metalloproteinases and has an impact on the expression of key genes of the extracellular matrix. We conclude that chronic or discretionary exposure to IRA could play a role that is more important than expected in premature skin aging.

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Section: Resultssupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Low to Moderate Doses of Infrared A Irradiation Impair Extracellular Matrix Homeostasis of the Skin and Contribute to Skin Photodamage

Robert

Bonnet²,

Marques³

et al. 2015

Skin Pharmacol Physiol

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“…Skin aging manifests wrinkles, diminished structural integrity and impaired wound healing due to alterations in the extracellular matrix formed predominantly of Colla1 (Jenkins, 2002;Watson et al, 2009). Furthermore, it has been reported that the expression of MMP1 in dermal fibroblasts is induced under oxidative stress conditions (Buechner et al, 2008;Nazaruk and Galicka, 2014). Interestingly, MMP1R transcripts were found to be drastically down-regulated in H 2 O 2 stressed cells pre-treated NannoG, in contrast to only extract-treated control cells.…”

Section: Nannog Positively Regulated Genes Involves In Skin Texture Amentioning

confidence: 79%

Skin Protective Effects of Nannochloropsis gaditana Extract on H2O2-Stressed Human Dermal Fibroblasts

Letsiou¹,

Kalliampakou

Gardikis³

et al. 2017

Front. Mar. Sci.

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Nowadays, there is huge interest in natural products obtained from marine organisms that can promote a state of health and well-being for humans. Microalgae represent a primary source of bioactive compounds that could be used as functional ingredients in cosmetic formulations. The aim of the present study is to evaluate, for the first time, the effects of Nannochloropsis gaditana extract against oxidative stress in human primary fibroblasts so as to investigate the potential applications of it in cosmetics. To gain an insight into the molecular mechanisms of N. gaditana bioactivity, we developed a new RT-qPCR platform for studying transcript accumulation for an array of selected genes (up to 100) involved in many skin-related processes including anti-aging, hydration, oxidative stress response, and DNA damage. For the oxidative stress evaluation, H 2 O 2 was used as a stressor. The study of the transcript accumulation of genes revealed that N. gaditana extract exhibits skin protection properties by mediating oxidative responses and apoptosis (including SOD1, GPX1, BID), positively regulates genes involves in skin texture and hydration (including AQP3, Col6A1, FBN1) and modulates the expression of genes involved in skin irritation, DNA damage and aging (including IL1R, PCNA, FOXO3). These findings indicate that the specific N. gaditana extract possesses significant in vitro skin protection activity against induced oxidative stress, and provide new insights into the beneficial role of microalgae bioactive compounds in cosmetic formulations protecting skin from oxidative stress.

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“…7) Among MMPs, MMP-1 is the most responsible for the degradation of type 1 collagen in the skin. [8][9][10] Collagen degradation and inhibition of collagen production impair the structural integrity of the skin during photoaging. Therefore, control of collagen metabolism may be useful for a variety of therapeutic and cosmetic applications.…”

mentioning

confidence: 99%

A Glycosidic Spinasterol from Koreana stewartia Promotes Procollagen Production and Inhibits Matrix Metalloproteinase-1 Expression in UVB-Irradiated Human Dermal Fibroblasts

Lee

et al. 2011

Biological & Pharmaceutical Bulletin

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UV irradiation, particularly that of UVB (290-320 nm), causes various adverse effects to human skin, the most serious being skin cancer and premature skin aging (photoaging). [1][2][3] The functional properties of skin depend on the integrity of collagens, which are the most abundant structural proteins in dermis. 4) Type 1 collagen, which accounts for 70-90% of all collagen, is synthesized by fibroblasts as a soluble precursor, type 1 procollagen, secreted and proteolytically processed to form insoluble collagen fibers in the dermis. 5,6) The production and fibrillar organization of collagen in the skin are reduced by UV irradiation whereas gene expression of matrix metalloproteinases (MMPs) is increased. 7) Among MMPs, MMP-1 is the most responsible for the degradation of type 1 collagen in the skin. [8][9][10] Collagen degradation and inhibition of collagen production impair the structural integrity of the skin during photoaging. Therefore, control of collagen metabolism may be useful for a variety of therapeutic and cosmetic applications.Recently, a variety of herbs and plants have traditionally been used in cosmetic applications for the treatment of collagen synthesis and collagenase inhibition. [11][12][13][14][15] It has been widely reported that natural compounds from plants are potential sources of MMP inhibitors, which may prevent or mitigated UV-induced skin aging. [16][17][18] Stewartia koreana (Theaceae), a deciduous tree, is native to Korea and grows throughout the whole area of Korea. It prefers a partly shaded to full sun area, and favors a rich, moist, well-drained, and acidic loam. The leaves are dark green, elliptical, and mildly serrulate, and alternately arranged on stem. In autumn, the leaves turn a bright red to reddish purple. Usually in July, white solitary flowers bloom with 5-6 petals and yellow stamens. The flowers open wider with a more flattened look than most other species of Stewartia. The fruits ripen as an inconspicuous pentagon-shaped one in October.The bark is well exfoliated, ranging in color from soft grays and tans to orange and reddish browns. 19) We previously reported that Stewarita koreana extract induced angiogenesis and extracellular matrix (ECM) remodeling in a mouse model. It has also been reported that alcohol extracts from Stewartia koreana stimulate vasculization in vivo 20) but there is no report for the individual components of the plant. In addition, our preliminary experiments showed that the alcohol extracts were very effective in restoring wounds on punched skin of the back of mice. Therefore, this study was initiated to determine the principal components that manifest the biological activity. We isolated a number of compounds from Stewarita koreana extract. In the present study, we identified an active compound, 3-O-b-D-glucopyranosylspinasterol (spinasterol-Glc), and investigated its effect on the levels of collagen and on the expression of MMP-1 in UVB-treated fibroblast cells. We found that spinasterol-Glc inhibits collagen degradation in UVB-induced fib...

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Changes of MMP-1 and collagen type Iα1 by UVA, UVB and IRA are differentially regulated by Trx-1

Cited by 86 publications

References 21 publications

Low to Moderate Doses of Infrared A Irradiation Impair Extracellular Matrix Homeostasis of the Skin and Contribute to Skin Photodamage

Low to Moderate Doses of Infrared A Irradiation Impair Extracellular Matrix Homeostasis of the Skin and Contribute to Skin Photodamage

Skin Protective Effects of Nannochloropsis gaditana Extract on H2O2-Stressed Human Dermal Fibroblasts

A Glycosidic Spinasterol from Koreana stewartia Promotes Procollagen Production and Inhibits Matrix Metalloproteinase-1 Expression in UVB-Irradiated Human Dermal Fibroblasts

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