Changes of Clinicopathologic Characteristics and Survival Outcomes of Anaplastic and Poorly Differentiated Thyroid Carcinoma

Lee, Doh Young; Won, Jae Kyung; Lee, Se‐Hoon; Park, Do Joon; Jung, Kyeong Cheon; Sung, Myung Whun; Wu, Hong Gyun; Kim, Kwang Hyun; Park, Young Joo; Hah, J. Hun

doi:10.1089/thy.2015.0316

Cited by 67 publications

(66 citation statements)

References 39 publications

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“…Of the four patients that died from the disease, three had distant metastasis. Reports on this specific topic are not very frequent and there is some inconsistency in the inclusion of anaplastic carcinoma in the same analysis of poorly differentiated, making it hard to establish really reliable data (15).…”

Section: Discussionmentioning

confidence: 99%

Surgical treatment for thyroid carcinoma: retrospective study with 811 patients in a Brazilian tertiary hospital

Cavalheiro

Matos

Leite

et al. 2016

Arch. Endocrinol. Metab.

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Objective: The aim of the present study was to describe the epidemiologic data, histological type, treatment and follow-up of the 811 patients treated for thyroid cancer in Instituto do Câncer do Estado de São Paulo (ICESP) over 5 years. Materials and methods: Retrospective analyses of electronic chart information. Results: There were 679 cases (83.7%) of papillary thyroid cancer, 61 (7.5%) of follicular carcinoma, 54 (6.7%) of medullary carcinoma, 11 (1.4%) of poorly differentiated carcinoma and 6 of anaplastic carcinoma (0.7%). The majority of patients were female (82.2%), and the mean age was 50.5 ± 15 years. Two hundred forty-two patients had disease persistence or recurrence. At the last follow-up, 629 (77.6%) patients were alive and disease free, 141 (17.4%) were alive with disease, and 41 (5.1%) were deceased, with 37 deaths related to thyroid cancer. Conclusion: This study was able to outline the profile, disease type and evolution of patients treated for thyroid cancer at a single tertiary hospital. Arch Endocrinol Metab. 2016;60(5):472-8

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Section: Discussionmentioning

confidence: 99%

Surgical treatment for thyroid carcinoma: retrospective study with 811 patients in a Brazilian tertiary hospital

Cavalheiro

Matos

Leite

et al. 2016

Arch. Endocrinol. Metab.

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“…It was reported that pure ATC (100% undifferentiated component) and ATC arising from PTC/FTC (>10% undifferentiated component, usually > 50%) have a similar behavior and unfavorable prognosis. On the other hand, PTC/FTC with ATC foci (<10% of undifferentiated cells in the background of differentiated cancer) showed significantly better outcome, with a 5‐year survival (81%) exceeding those of ATC (14%) and even of PDC (66%) . Interestingly, the number of cases of pure ATC decreased over the time, while cases of ATC with coincident PTC/FTC became much more frequent (up to half of all ATC) …”

Section: Anaplastic (Undifferentiated) Carcinomamentioning

confidence: 99%

“…Up to half of ATC samples may contain a well‐differentiated component, usually antecedent or coexisting PTC and FTC, or occasionally a minor ATC component is found on postoperative pathological examination of patients with differentiated thyroid carcinoma . Recent Korean studies addressed a significance of coincident ATC and PTC/FTC . It was reported that pure ATC (100% undifferentiated component) and ATC arising from PTC/FTC (>10% undifferentiated component, usually > 50%) have a similar behavior and unfavorable prognosis.…”

Section: Anaplastic (Undifferentiated) Carcinomamentioning

confidence: 99%

The new 4th edition World Health Organization classification for thyroid tumors, Asian perspectives

Kakudo

Bychkov

Bai

et al. 2018

Pathology International

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“…22) In previous study, both RAI and RT were effective for the improvement of survival of DTC with anaplastic foci and showed no significant difference. 23) Therefore, more research is needed to find out which treatment is more appropriate for DTC with anaplastic foci.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Prognosis of Differentiated Thyroid Carcinoma with Small Foci of Anaplastic Transformation

et al. 2017

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Background and Objectives: Anaplastic thyroid carcinoma (ATC) is commonly related with concurrent differentiated thyroid carcinoma (DTC). We aimed to examine the clinicopathologic characteristics, prognosis and gene expression of DTC with anaplastic foci. Materials and Methods: Eighteen patients with DTC with anaplastic foci were enrolled in this study. To compare the clinicopathologic characteristics and prognosis of anaplastic foci subjects with conventional ATC or DTC, we additionally included 12 ATC and 1030 DTC patients who diagnosed during same period. Immunohistochemistry was performed to check the gene expression in anaplastic foci and DTC component. Results: In anaplastic foci group, tumor size was larger (2.5±1.3 vs. 1.2±0.9 cm, p=0.001), distant metastasis was more frequent (11.1 vs. 0%, p=0.000) and 1-year survival rate was low (88.9 vs. 100%, p=0.000) than DTC group. In contrast, compared with ATC group, anaplastic foci group showed younger age at diagnosis (50±16 vs. 63±18 years, p=0.039), smaller tumor size (2.5±1.3 vs. 3.8±1.4 cm, p=0.027), less distant metastasis (11.1 vs. 41.7%, p=0.084) and longer 1-year survival rate (88.9 vs. 25.0%, p=0.001). Expression of p53 protein was observed in 100% of anaplastic foci, ATC and 12.5% of papillary thyroid carcinoma component. Conclusion: DTC with foci of anaplastic transformation has a worse prognosis than DTC, but a better prognosis than ATC. Our results support that DTC with anaplastic foci was intermediate state from DTC to ATC.

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Changes of Clinicopathologic Characteristics and Survival Outcomes of Anaplastic and Poorly Differentiated Thyroid Carcinoma

Abstract: The choice of treatment of ATC and PDTC could be modified according to resectability and lymphatic invasion of the cancer.

Cited by 67 publications

References 39 publications

Surgical treatment for thyroid carcinoma: retrospective study with 811 patients in a Brazilian tertiary hospital

Surgical treatment for thyroid carcinoma: retrospective study with 811 patients in a Brazilian tertiary hospital

The new 4th edition World Health Organization classification for thyroid tumors, Asian perspectives

Clinical Characteristics and Prognosis of Differentiated Thyroid Carcinoma with Small Foci of Anaplastic Transformation

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