Changes of Carotid Intima-Media Thickness After Sleeve Gastrectomy in High Cardiovascular Risk Patients: a Prospective Study

Salman, Mohamed Abdalla; Salman, Ahmed; Sherbiny, Mohammad El; Elkholy, Shaimaa; Youssef, Abou-Bakr M.; Labib, Safa; El-Din, Mohamed Tag; Monazea, Khaled; Tourky, Mohamed; Mikhail, Hani Maurice Sabri; Maurice, Karim K.; Abdallah, Ahmed; Mostafa, Mohamed Saber; Hussein, Ahmed M.; Abdelsalam, Ahmed; Allah, Nesrin Abd; Saadawy, Amr M. Ismaeel; Shaaban, Hossam El‐Din; Sarhan, Mohamed D.

doi:10.1007/s11695-021-05419-5

Cited by 6 publications

(6 citation statements)

References 25 publications

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“…In cohort studies, although most of the selected studies [ 16 , 32 , 33 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ] showed representativeness of the cases, the majority of them were distinguished by a lack of nonexposed group definition information. Since most of the studies did not include a control group, they were not assessed for comparability.…”

Section: Resultsmentioning

confidence: 99%

“… ( A ) Forest plot displaying standardized mean difference and 95% confidence intervals showing the consequence of bariatric surgery on IMT [ 16 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ]; ( B ) Leave-one-out sensitivity analyses indicating the effect of bariatric surgery on IMT [ 16 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , …”

Section: Figurementioning

confidence: 99%

“… Subgroup analysis based on the follow-up period [ 32 , 33 , 34 , 35 , 36 , 37 , 39 , 40 , 41 , 42 , 43 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 ] ( A ) and type of surgery [ 33 , 37 , 38 , 39 , 40 , 41 , 42 , 45 , 49 , 50 , 52 , 53 , 54 , 58 , 59 , 60 ] ( B ). …”

Section: Figurementioning

confidence: 99%

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Effect of Bariatric Surgery on Intima Media Thickness: A Systematic Review and Meta-Analysis

Jamialahmadi

Reiner

Alidadi

et al. 2022

JCM

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Background: Obesity, and in particular extreme obesity, as a global health problem is an important risk factor for many diseases, including atherosclerotic cardiovascular disease (ACVD). Bariatric surgery might stop or slow atherogenesis by decreasing excessive weight in the early stages of atherogenesis, by suppressing low-grade systemic inflammation as well as by inhibiting oxidative stress and endothelial dysfunction. The aim of this meta-analysis was to provide an answer to whether bariatric surgery has a significant effect on intima-media thickness (IMT) which is a surrogate marker of early atherosclerosis and has a good correlation with atherosclerotic coronary heart disease. Methods: A systematic literature search in PubMed, Scopus, Embase, and Web of Science as well as grey literature was performed from inception to 1 July 2022. The meta-analysis was performed using Comprehensive Meta-Analysis (CMA) V3 software. Overall, the estimate of effect size was measured by a random effects meta-analysis. To account for the heterogeneity of studies regarding study design, characteristics of the populations, and treatment duration, a random-effects model (using the DerSimonian–Laird method) and the generic inverse variance weighting approach were used. To assess the existence of publication bias in the meta-analysis, the funnel plot, Begg’s rank correlation, and Egger’s weighted regression tests were used. Results: The meta-analysis of 30 trials, including 1488 subjects, demonstrated a significant decrease in IMT after bariatric surgery. The reduction in IMT was also robust in the leave-one-out sensitivity analysis. It must be stressed that the results of the random-effects meta-regression did not suggest any relationship between the changes in IMT and delta body mass index (BMI) or duration of follow-up after the bariatric surgery. However, the subgroup analyses showed a better IMT reduction after laparoscopic sleeve gastrectomy (LSG) when compared to Roux-en-Y gastric bypass (RYGB). Within a year, the IMT follow-up values showed a further improvement. Conclusions: Bariatric surgery significantly reduced IMT. Significant associations were found between the surgery type and IMT changes, as well as a significant effect of follow-up duration on the changes of IMT after bariatric surgery.

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Section: Resultsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Effect of Bariatric Surgery on Intima Media Thickness: A Systematic Review and Meta-Analysis

Jamialahmadi

Reiner

Alidadi

et al. 2022

JCM

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“…Based on previous studies, a significant weight loss can modulate major metabolic risk factors and conceivably reduce fasting plasma glucose, HbA1c, homeostatic model assessment for insulin resistance (HOMA‐IR), blood pressure, total cholesterol, LDL‐C, and triglycerides 99,100 . Even, greater weight loss achieved by bariatric surgery can completely normalize these metabolic factors 100 .…”

Section: The Epidemiological Association Of Obesity With Nafld and Ca...mentioning

confidence: 99%

Weight loss breaks the bond between nonalcoholic fatty liver disease and cardiovascular diseases: A clinical and epidemiological perspective

Ala

Eftekhar

2023

Obesity Reviews

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Summary Nonalcoholic fatty liver disease (NAFLD) is a growing health concern that is closely related to obesity and metabolic syndrome. In particular, NAFLD has been increasingly reported in adolescents and young adults in recent years. Cardiovascular diseases (CVDs) such as cardiac remodeling, heart failure, myocardial infarction, valvular heart diseases, and arrhythmia are more common in patients with NAFLD. CVD are the major cause of mortality in NAFLD. Although NAFLD often affects patients with obesity/overweight, it can also affect subjects with normal body mass index (BMI), known as lean NAFLD, which has a strong correlation with CVD. Obesity imposes a considerably increased risk of NAFLD and CVD. Consistently, weight‐lowering approaches that can pronouncedly decrease body weight and maintain it in the long term, such as bariatric surgery and treatment with semaglutide and tirzepatide, have been promising in alleviating both CVD and NAFLD. Interestingly, compared with patients with NAFLD and obesity, a minimal amount of weight loss resolves NAFLD in lean patients. Besides the widespread use of bariatric surgery, the development of new GLP‐1 agonists and GLP‐1 GIP agonists revolutionized the treatment of obesity in recent years. Here, we discuss the interwoven correlation between obesity, NAFLD, and CVD and the benefits of weight‐lowering approaches.

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“…Further, the beneficial effects of RYGB on markers of atherosclerosis such as brachial artery flow-mediated dilation and cIMT paralleled a decrease in C-reactive protein (CRP) [ 15 ]. In addition, after SG, the reduction in cIMT was associated with a decrease in insulin resistance and several pro-inflammatory markers [ 16 ]. Published data of our own have also shown this association between the decrease in inflammatory markers after both SG and RYGB and the reduction in cIMT in women [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

The Beneficial Changes on Inflammatory and Endothelial Biomarkers Induced by Metabolic Surgery Decreases the Carotid Intima-Media Thickness in Men

Cobeta

Pariente²,

Osorio³

et al. 2022

Biomolecules

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Obesity increases cardiovascular risk in men through several mechanisms. Among them, low-grade chronic inflammation and obesity-associated hypogonadism have been described. We aimed to study the effects of metabolic surgery on the carotid-intima media thickness through changes in inflammatory, endothelial biomarkers, and testosterone. We included 60 men; 20 submitted to laparoscopic Roux-en-Y gastric bypass (RYGB), 20 to sleeve gastrectomy (SG), and 20 to lifestyle modification (controls). Several inflammatory and endothelial biomarkers and total testosterone (TT) were measured at baseline and six months after surgery. Free testosterone (FT) was calculated, and carotid intima-media thickness (cIMT) was measured by ultrasonography. Compared to controls, cIMT decreased after surgery concomitantly with CRP, PAI-1, sICAM-1, and IL-18 (p < 0.01) and with an increase in sTWEAK (p = 0.027), with no differences between RYGB and SG. The increase in TT and FT after surgery correlated with the changes in cIMT (p = 0.010 and p = 0.038, respectively), but this association disappeared after multivariate analysis. Linear regression showed that sTWEAK (ß = −0.245, p = 0.039), PAI-1 (ß = 0.346, p = 0.005), and CRP (ß = 0.236, p = 0.049) were associated with the changes in cIMT (R2 = 0.267, F = 6.664, p = 0.001). In conclusion, both RYGB and SG induced improvements in inflammation and endothelial biomarkers that drove a decrease in cIMT compared to men with obesity who submitted to diet and exercise.

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Changes of Carotid Intima-Media Thickness After Sleeve Gastrectomy in High Cardiovascular Risk Patients: a Prospective Study

Cited by 6 publications

References 25 publications

Effect of Bariatric Surgery on Intima Media Thickness: A Systematic Review and Meta-Analysis

Effect of Bariatric Surgery on Intima Media Thickness: A Systematic Review and Meta-Analysis

Weight loss breaks the bond between nonalcoholic fatty liver disease and cardiovascular diseases: A clinical and epidemiological perspective

The Beneficial Changes on Inflammatory and Endothelial Biomarkers Induced by Metabolic Surgery Decreases the Carotid Intima-Media Thickness in Men

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