Changes of adiponectin and inflammatory cytokines after periodontal intervention in type 2 diabetes patients with periodontitis

Sun, Weilian; Chen, Lili; Zhang, Suzhan; Ren, Yong; Qin, Guangming

doi:10.1016/j.archoralbio.2010.08.001

Cited by 57 publications

(52 citation statements)

References 17 publications

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“…Our previous study also showed the beneficial effect of periodontal therapy on diabetes with acceptable glycemic control (HbA1c between 6.5% and 7.5%) (13), in contrast to the studies of Jones et al (14) and Lalla et al (15).…”

Section: Introductionmentioning

confidence: 45%

“…It can produce some inflammatory cytokines (e.g. CRP, TNF-α and IL-6) in the local tissue, as well as elevating their circulating levels (13,22,23). CRP is an important mediator of inflammation, mainly synthesized in the liver.…”

Section: Discussionmentioning

confidence: 99%

“…TNF-α is another important inflammatory cytokine, closely linked to IR (23), which plays a role in the regulation of CRP expression. Several studies showed that circulating CRP and TNF-α levels are increased in T2DM patients with periodontitis (13,22,23). Adiponectin is the only adipocytokine identified to date, secreted specifically by mature adipocytes, which plays an important negative regulatory role in some physiological and pathological processes (10), including multiple protective roles such as antidiabetic, antiatherosclerotic, and anti-inflammatory factors (24).…”

Section: Discussionmentioning

confidence: 99%

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Inflammatory Cytokines, Adiponectin, Insulin Resistance and Metabolic Control after Periodontal Intervention in Patients with Type 2 Diabetes and Chronic Periodontitis

et al. 2011

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Objective To evaluate the effects of periodontal intervention on inflammatory cytokines, adiponectin, insulin resistance (IR), and metabolic control and to investigate the relationship between type 2 diabetes mellitus (T2DM) and moderately poor glycemic control and chronic periodontitis. Methods and Patients A total of 190 moderately poorly controlled (HbA1c between 7.5% and 9.5%) T2DM patients with periodontitis were randomly divided into two groups according to whether they underwent periodontal intervention: T2DM-NT and T2DM-T group. The levels of serum adiponectin, C-reactive protein (CRP), tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), lipid profile, glucose, insulin, homeostasis model of assessment -insulin resistance (HOMA-IR) and homeostasis model assessment of β-cell function (HOMA-β) were measured at baseline and after 3 months. Results The levels of clinical periodontal variables, the probing depth, attachment loss, bleeding index, and plaque index were improved significantly in T2DM-T group after 3 months compared to T2DM-NT group (all p<0.01). After 3 months, the serum levels of hsCRP, TNF-α, IL-6, fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), fasting insulin (FINS) and HOMA-IR index decreased, and adiponectin was significantly increased in T2DM-T group compared to those in the T2DM-NT group (p<0.05 or p<0.01). Conclusion Periodontal intervention can improve glycemic control, lipid profile and IR, reduce serum inflammatory cytokine levels and increase serum adiponectin levels in moderately poorly controlled T2DM patients.

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Section: Introductionmentioning

confidence: 45%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Inflammatory Cytokines, Adiponectin, Insulin Resistance and Metabolic Control after Periodontal Intervention in Patients with Type 2 Diabetes and Chronic Periodontitis

et al. 2011

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“…A second level full text search was initiated on those studies remaining. One study (Sun et al, 2010) was deemed a duplicate report. One study (Singh et al, 2008) not revealed by MEDLINE search was gleaned from the bibliography of a recent review.…”

Section: Resultsmentioning

confidence: 99%

Evidence that periodontal treatment improves diabetes outcomes: a systematic review and meta‐analysis

Engebretson

Kocher

2013

Journal of Periodontology

108

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Context The effect of periodontal therapy on diabetes outcomes has not been established. Objective This update examines the effect of periodontal treatment on diabetes outcomes. Data Sources Literature since October 2009 using MEDLINE. Study eligibility criteria Published RCTs including periodontal therapy for diabetic subjects, a metabolic outcome, an untreated control group, and follow up of 3 months. Data Extraction Predefined data fields, including study quality indicators were used. Data Synthesis A search revealed 56 publications of which 9 met inclusion criteria. Mean change of HbA1c from baseline was compared across treatment groups. Pooled analysis was based on random effects models. Results A meta analysis indicated a mean treatment effect of −0.36% HbA1c (CI −0.54, − 0.19) compared to no treatment after periodontal therapy (p<0.0001). Heterogeneity tests revealed only minimal evidence of publication bias (I2 =9%). Limitations Small sample size and high risk of bias remain problematic for studies of this type. Periodontal therapy varied considerably. Conclusion The modest reduction in HbA1c observed as a result of periodontal therapy in subjects with type 2 diabetes is consistent with previous systematic reviews. Despite this finding, multi-center trials of sufficient sample size are lacking.

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“…Moreover, a study showed that periodontal therapy helped to improve glycemic control. 55 With studies reporting a reduction in arterial blood flow in patients with PD, Tonetti et al showed an improvement in flow-mediated dilatation of brachial artery and reduced plasma soluble E-selectin in PD patients who received intensive therapy. 49 Another study also showed an improvement of endothelial dysfunction following PD treatment.…”

Section: Periodontal Treatment and Cerebrovascular Diseasementioning

confidence: 99%

Interrelationship between Cerebrovascular Disease and Periodontitis

Yooprasert¹,

Siribamrungwong²,

Chaikomon³

et al. 2015

International Journal of Experimental Dental Science

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Cerebrovascular disease (CVD) is the second most common cause of death and contributes to a high morbidity worldwide. The major etiology is an atherosclerosis. Many well-known risk factors, such as hypertension, dyslipidemia and diabetes, are defined as traditional risk factors. Treatment and control of traditional risk factors also improve both cardiovascular and cerebrovascular outcomes. To date, many studies reported an association between stroke and nontraditional risk factors, such as infectious diseases or inflammatory process. Periodontal disease (PD) is an infection of the gum and other toothsupporting structures, with an on going inflammatory process and affects a large number of populations worldwide. Current evidence demonstrated the local and systemic inflammatory effects in periodontitis induced an atherosclerosis. This review aims to provide the current knowledge on the association between periodontal disease and cerebrovascular disease.

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Changes of adiponectin and inflammatory cytokines after periodontal intervention in type 2 diabetes patients with periodontitis

Cited by 57 publications

References 17 publications

Inflammatory Cytokines, Adiponectin, Insulin Resistance and Metabolic Control after Periodontal Intervention in Patients with Type 2 Diabetes and Chronic Periodontitis

Inflammatory Cytokines, Adiponectin, Insulin Resistance and Metabolic Control after Periodontal Intervention in Patients with Type 2 Diabetes and Chronic Periodontitis

Evidence that periodontal treatment improves diabetes outcomes: a systematic review and meta‐analysis

Interrelationship between Cerebrovascular Disease and Periodontitis

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