Changes in white matter microstructure during adolescence

Giorgio, Antonio; Watkins, Kate E.; Douaud, Gwenaëlle; James, Anthony; James, Susan; Stefano, Nicola De; Matthews, Paul M.; Smith, Stephen M.; Johansen‐Berg, Heidi

doi:10.1016/j.neuroimage.2007.07.043

Cited by 266 publications

(221 citation statements)

References 44 publications

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“…Taken together, genetic vulnerability for schizophrenia may result in frontostriatal neurodevelopmental changes already before adolescence and this may evolve into decreased mean FA during adulthood. In contrast to decreasing FA measures in schizophrenia offspring, our finding of an increase in mean FA in the tracts connecting the nucleus accumbens and DLPFC with progressing age in typical developing control adolescents is consistent with previous DTI studies (Giorgio et al, 2008;Lebel et al, 2008;Peper et al, 2013;Peters et al, 2012). As FA may be used as an index for the microstructural directionality of white matter fiber bundles (Basser and Pierpaoli, 1996), our finding of increasing FA across age in control adolescents may reflect maturation of white matter tracts across adolescence.…”

Section: Discussionsupporting

confidence: 91%

Changes in White Matter Organization in Adolescent Offspring of Schizophrenia Patients

Leeuw

Bohlken

Mandl

et al. 2016

Neuropsychopharmacol

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Schizophrenia is associated with frontostriatal network impairments underlying clinical and cognitive symptoms. We previously found disruptions in anatomical pathways, including the tract connecting the left nucleus accumbens and left dorsolateral prefrontal cortex (DLPFC). Similar deficits are observed in unaffected siblings of schizophrenia patients, indicating that these deficits are linked to a genetic vulnerability for the disorder. Frontostriatal tract disruptions may arise during adolescence, preceding the clinical manifestation of the disorder. However, to date, no studies have been performed to investigate frontostriatal tract connections in adolescents who are at increased familial risk for schizophrenia. In this study, we investigate the impact of familial risk on frontostriatal tract connections using diffusion tensor imaging in 27 adolescent offspring of schizophrenia patients and 32 matched control adolescents, aged 10-18 years. Mean fractional anisotropy (FA) was calculated for the tracts connecting the striatum (caudate nucleus, putamen, nucleus accumbens) and frontal cortex regions (DLPFC, medial orbital frontal cortex, inferior frontal gyrus). As expected, based on siblings data, we found an impact of familial risk on frontostriatal development: schizophrenia offspring showed increased FA in the tracts connecting nucleus accumbens and DLPFC as compared with control adolescents. Moreover, while FA increased across age in control adolescents, it did not in schizophrenia offspring. We did not find differences in FA in other frontostriatal tracts. These results indicate altered development of white matter in subjects who are at familial risk for schizophrenia and may precede frontostriatal white matter alterations in adult schizophrenia patients and siblings.

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Section: Discussionsupporting

confidence: 91%

Changes in White Matter Organization in Adolescent Offspring of Schizophrenia Patients

Leeuw

Bohlken

Mandl

et al. 2016

Neuropsychopharmacol

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“…Such findings are supported by resting EEG studies demonstrating that signal coherence in the alpha rhythm between posterior and anterior electrodes increases with age (32). However, our finding that changes in interhemispheric correlations were minimal from Ϸ7-9 years into adulthood, despite significant development of the corpus callosum into young adulthood (33,34), suggests that elaboration of the myelin sheath is unlikely to be the sole variable involved. Consistent with this notion, as previously described (22), data by Honey and colleagues (35) suggest that spontaneous activity itself may, in part, account for the changes in interregional correlations (35).…”

Section: Discussionsupporting

confidence: 76%

The maturing architecture of the brain's default network

Fair¹,

Cohen

Dosenbach

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

1,211

976

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In recent years, the brain's “default network,” a set of regions characterized by decreased neural activity during goal-oriented tasks, has generated a significant amount of interest, as well as controversy. Much of the discussion has focused on the relationship of these regions to a “default mode” of brain function. In early studies, investigators suggested that, the brain's default mode supports “self-referential” or “introspective” mental activity. Subsequently, regions of the default network have been more specifically related to the “internal narrative,” the “autobiographical self,” “stimulus independent thought,” “mentalizing,” and most recently “self-projection.” However, the extant literature on the function of the default network is limited to adults, i.e., after the system has reached maturity. We hypothesized that further insight into the network's functioning could be achieved by characterizing its development. In the current study, we used resting-state functional connectivity MRI (rs-fcMRI) to characterize the development of the brain's default network. We found that the default regions are only sparsely functionally connected at early school age (7–9 years old); over development, these regions integrate into a cohesive, interconnected network.

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“…11 The different age ranges may be another factor since WM volumes and anisotropy increase into adolescence, 22,23 and the preadolescent cocaine-exposed children would have been subjected to many more environmental influences compared to the young preschoolers in our study.…”

mentioning

confidence: 89%