Changes in Triglyceride Levels and Risk for Coronary Heart Disease in Young Men

Tirosh, Amir; Rudich, Assaf; Shochat, Tzipora; Tekes‐Manova, Dorit; Israeli, Eran; Henkin, Yaakov; Kochba, Ilan; Shai, Iris

doi:10.7326/0003-4819-147-6-200709180-00007

Cited by 141 publications

(107 citation statements)

References 30 publications

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“…in the IFG group, we found that decreasing levels of triacylglycerol reduced the risk of diabetes. Lifestyle changes are associated with changes in triacylglycerol [38]. Yet, decreasing triacylglycerol independently reduced the risk of diabetes in our study, when adjusted for change in alcohol consumption or weight change (not shown).…”

Section: Discussioncontrasting

confidence: 52%

“…Yet, decreasing triacylglycerol independently reduced the risk of diabetes in our study, when adjusted for change in alcohol consumption or weight change (not shown). Another observational study has shown that decreases in triacylglycerol decreased the risk of coronary heart disease, independently of several lifestyle changes and medication, when compared with stable high triacylglycerol [38]. Based on our results, future studies may look further into the degree to which changes in triacylglycerol determine progression to diabetes, as we were unable to sufficiently adjust for lifestyle changes.…”

Section: Discussionmentioning

confidence: 76%

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Determinants of progression from impaired fasting glucose and impaired glucose tolerance to diabetes in a high-risk screened population: 3 year follow-up in the ADDITION study, Denmark

et al. 2007

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Aims/hypothesis We sought to identify determinants of progression from impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) to diabetes in high-risk screened individuals. Methods In general practices in Denmark, stepwise screening for type 2 diabetes mellitus in persons aged 40 to 69 years included a risk questionnaire, random blood glucose, HbA 1c , fasting blood glucose and an OGTT. The 1,821 individuals with IGT or isolated IFG (WHO 1999) were re-invited after 1 and 3 years. Follow-up data on glucose measurements were available in 1,510 individuals and additional clinical data in 1,002 collected at the 3-year visits. Regression models using interval censoring were used. Results Progression rates from IFG and IGT to diabetes over 3.5 years were 11.8 and 17.0 per 100 person-years, respectively and were particularly high in the first year. Conclusions/interpretation Higher levels of glucose measures, larger BMI, known hypertension and hypertriacylglycerolaemia are significant determinants of progression in high-risk screened individuals. Weight loss of 1 kg/year or reduction of hypertriacylglycerolaemia markedly reduced the risk of diabetes.

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Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 76%

Determinants of progression from impaired fasting glucose and impaired glucose tolerance to diabetes in a high-risk screened population: 3 year follow-up in the ADDITION study, Denmark

et al. 2007

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“…This association persisted both in subjects who were overweight and in those who were not. PA is beneficially associated with blood lipids in different populations, especially HDL cholesterol and TG [27][28][29]. One mechanism by which exercise is responsible for lowered TG and increased HDL cholesterol is the increased use of TG as energy during exercise.…”

Section: Discussionmentioning

confidence: 99%

Dose-response association between physical activity and metabolic syndrome

Bacevičienė¹,

Lukšienė

Česnaitienė

et al. 2013

Open Medicine

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“…The outcome definition for CAD in the MELANY study is angiography-proven stenosis of 50% in at least one coronary artery (1,17,18). Follow-up began at participants' first visit to the screening center and ended at the time of CAD diagnosis, death, retirement from military service, or 8th March 2011, whichever came first.…”

Section: Outcomes and Follow-upmentioning

confidence: 99%

Coronary artery disease risk among obese metabolically healthy young men

Twig

Gerstein

Shor

et al. 2015

European Journal of Endocrinology

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Objective: The aim of this study was to assess coronary artery disease (CAD) risk among obese young men without metabolic risk factors. Design: A longitudinal study in a historical cohort. Methods: Incident CAD during a median follow-up of 6.1 years was assessed among 31 684 young men (mean age 31.2G5.7 years) of the Metabolic, Lifestyle and Nutrition Assessment in Young Adults (MELANY) cohort. Participants were categorized by BMI and the number of metabolic abnormalities (based on the Adult Treatment Panel-III). Metabolically healthy (MH) obesity was defined as BMI R30 kg/m 2 in the presence of normal blood pressure (BP) and normal levels of fasting glucose, triglyceride, and HDL-cholesterol (HDL-c) levels (nZ599; 1.9%). Cox proportional hazard models were applied.Results: There were 198 new cases of CAD that were diagnosed during 209 971 person-years of follow-up, of which six cases occurred among MH obese. The incidence of CAD among MH lean, overweight, and obese participants was 0.23, 0.45, and 1.0/1000 person-years respectively. In a multivariable model adjusted for clinical and biochemical CAD risk factors, a higher CAD risk was observed among MH-obese (hazard ratioZ3.08; 95% CIZ1.10-8.68, PZ0.033), compared to MH-normal weight subjects. This risk persisted when BMI was treated as a time-dependent variable, or when fasting glucose, HDL-c, triglycerides, or BP were added to the model. Similar results were also obtained when a more permissive definition of MH was used. Conclusions: Obesity may continue to contribute to increased risk for incident CAD in young men even in the presence of a healthy metabolic profile.

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Changes in Triglyceride Levels and Risk for Coronary Heart Disease in Young Men

Cited by 141 publications

References 30 publications

Determinants of progression from impaired fasting glucose and impaired glucose tolerance to diabetes in a high-risk screened population: 3 year follow-up in the ADDITION study, Denmark

Determinants of progression from impaired fasting glucose and impaired glucose tolerance to diabetes in a high-risk screened population: 3 year follow-up in the ADDITION study, Denmark

Dose-response association between physical activity and metabolic syndrome

Coronary artery disease risk among obese metabolically healthy young men

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