Changes in the nephron and neuroendocrine apparatus of the kidneys after injection of salmonella endotoxin

Ultrastructural changes in the interstitial cells of the renal medulla during endotoxin shock

“…2, d). A similar endothelial restructuring with the formation of grapelike vesicles was observed in anesthetized dogs after intracoronary infusion of l e u k o t r i e n e C 4 [3]. In addition, intravascular changes occurred in the capillaries surrounded by IC, These changes were similar to those observed in the microcirculatory bed of other components of rat and dog kidney [6,7].…”

“…Although prostaglandins and their precursors are found in almost all organs and tissues, they have been reliably identified as lipid inclusions only in the interstitial cells (IC) of the renal medulla [3,9]. In the kidney, the content of prostaglandin E 2 is the highest [10]; during endotoxemia its blood level increases markedly, which leads to lung edema and pulmonary hypertension, induces local and systemic hemodynamic changes, and adversely affects the function of various organs [12].…”