Changes in the hormone dependency of epithelial cell proliferation in the genital tract of mice following neonatal oestrogen treatment

Transgenerational Effect of Neonatal Vitamin A or D Treatment (Hormonal Imprinting) on the Hormone Content of Rat Immune Cells

“…Imprinting infl uences not only the maturation of the receptor-signal transduction system, but also the hormone production of the imprinted cell [6] . However, in the critical period, the presence of molecules, similar but not identical with the target hormone, can disturb the normal receptor-hormone connection and false imprinting develops [7,8] with life-long genetic (aberrant gene function [9] ), morphological, biochemical (alteration of cell proliferation, change of hormone production [4,10,11] ), and sexual behavioral [12] consequences (e.g., loss of libido). Some of these misimprintings are transmitted to the progeny generations [13 -16] by, at present, unknown mechanism.…”

Transgenerational Effect of Neonatal Vitamin A or D Treatment (Hormonal Imprinting) on the Hormone Content of Rat Immune Cells

“…Imprinting infl uences not only the maturation of the receptor-signal transduction system, but also the hormone production of the imprinted cell [6] . However, in the critical period, the presence of molecules, similar but not identical with the target hormone, can disturb the normal receptor-hormone connection and false imprinting develops [7,8] with life-long genetic (aberrant gene function [9] ), morphological, biochemical (alteration of cell proliferation, change of hormone production [4,10,11] ), and sexual behavioral [12] consequences (e.g., loss of libido). Some of these misimprintings are transmitted to the progeny generations [13 -16] by, at present, unknown mechanism.…”

Prolonged effect of an H1‐receptor blocker antihistamine on the histamine content of white blood cells and mast cells

“…[3][4][5][6] This can be manifested at receptor, biochemical, genetic, morphological and even at behavioural levels. 3,[6][7][8][9][10][11][12] Recently it was demonstrated that hormonal imprinting alters not only the binding capacity of receptors, but the eventual hormone production of the imprinted cell. When newborn rats were treated with interleukin-6 13 or serotonin, 14 their white blood cells and mast cells contained altered amounts of the imprinter or related hormone at the adult stage.…”

Prolonged impact of five imprinters on the serotonin content of white blood cells and mast cells of weanling rats: outstanding effect of benzpyrene and chlorpheniramine

“…As a consequence of this process the receptor-signal transduction system reaches its binding capacity characteristic to the adult age (Csaba, 1980(Csaba, , 1994(Csaba, , 2000. During that time, in the presence of molecules similar to the target hormone (other members of a hormone family, drugs, synthetic hormones, environmental pollutants) faulty imprinting develops with life-long receptorial, morphological, biochemical, behavioral, even genetic consequences (Bern et al, 1975(Bern et al, , 1987Gibson et al, 1991;Iguchi, 1992;Mirzahosseini et al, 1996;Nelson et al, 1994;Tchernitchin and Tchernitchin, 1992). In case of continuously developing cells (e.g.…”

Transgenerational Effect of Neonatal Vitamin A or D Treatment (Hormonal Imprinting) on the Hormone Content of Rat Immune Cells

“…Imprinting infl uences not only the maturation of the receptor-signal transduction system, but also the hormone production of the imprinted cell [6] . However, in the critical period, the presence of molecules, similar but not identical with the target hormone, can disturb the normal receptor-hormone connection and false imprinting develops [7,8] with life-long genetic (aberrant gene function [9] ), morphological, biochemical (alteration of cell proliferation, change of hormone production [4,10,11] ), and sexual behavioral [12] consequences (e.g., loss of libido). Some of these misimprintings are transmitted to the progeny generations [13 -16] by, at present, unknown mechanism.…”

Prolonged effect of an H1‐receptor blocker antihistamine on the histamine content of white blood cells and mast cells

“…[3][4][5][6] This can be manifested at receptor, biochemical, genetic, morphological and even at behavioural levels. 3,[6][7][8][9][10][11][12] Recently it was demonstrated that hormonal imprinting alters not only the binding capacity of receptors, but the eventual hormone production of the imprinted cell. When newborn rats were treated with interleukin-6 13 or serotonin, 14 their white blood cells and mast cells contained altered amounts of the imprinter or related hormone at the adult stage.…”

Prolonged impact of five imprinters on the serotonin content of white blood cells and mast cells of weanling rats: outstanding effect of benzpyrene and chlorpheniramine

“…As a consequence of this process the receptor-signal transduction system reaches its binding capacity characteristic to the adult age (Csaba, 1980(Csaba, , 1994(Csaba, , 2000. During that time, in the presence of molecules similar to the target hormone (other members of a hormone family, drugs, synthetic hormones, environmental pollutants) faulty imprinting develops with life-long receptorial, morphological, biochemical, behavioral, even genetic consequences (Bern et al, 1975(Bern et al, , 1987Gibson et al, 1991;Iguchi, 1992;Mirzahosseini et al, 1996;Nelson et al, 1994;Tchernitchin and Tchernitchin, 1992). In case of continuously developing cells (e.g.…”

Transgenerational Effect of Neonatal Vitamin A or D Treatment (Hormonal Imprinting) on the Hormone Content of Rat Immune Cells

“…Imprinting infl uences not only the maturation of the receptor-signal transduction system, but also the hormone production of the imprinted cell [6] . However, in the critical period, the presence of molecules, similar but not identical with the target hormone, can disturb the normal receptor-hormone connection and false imprinting develops [7,8] with life-long genetic (aberrant gene function [9] ), morphological, biochemical (alteration of cell proliferation, change of hormone production [4,10,11] ), and sexual behavioral [12] consequences (e.g., loss of libido). Some of these misimprintings are transmitted to the progeny generations [13 -16] by, at present, unknown mechanism.…”

Prolonged effect of an H1‐receptor blocker antihistamine on the histamine content of white blood cells and mast cells

“…[3][4][5][6] This can be manifested at receptor, biochemical, genetic, morphological and even at behavioural levels. 3,[6][7][8][9][10][11][12] Recently it was demonstrated that hormonal imprinting alters not only the binding capacity of receptors, but the eventual hormone production of the imprinted cell. When newborn rats were treated with interleukin-6 13 or serotonin, 14 their white blood cells and mast cells contained altered amounts of the imprinter or related hormone at the adult stage.…”

Prolonged impact of five imprinters on the serotonin content of white blood cells and mast cells of weanling rats: outstanding effect of benzpyrene and chlorpheniramine

“…As a consequence of this process the receptor-signal transduction system reaches its binding capacity characteristic to the adult age (Csaba, 1980(Csaba, , 1994(Csaba, , 2000. During that time, in the presence of molecules similar to the target hormone (other members of a hormone family, drugs, synthetic hormones, environmental pollutants) faulty imprinting develops with life-long receptorial, morphological, biochemical, behavioral, even genetic consequences (Bern et al, 1975(Bern et al, , 1987Gibson et al, 1991;Iguchi, 1992;Mirzahosseini et al, 1996;Nelson et al, 1994;Tchernitchin and Tchernitchin, 1992). In case of continuously developing cells (e.g.…”