Changes in the balance between Treg and Th17 cells in patients with chronic hepatitis B

Su, Zhijun; Yu, Xueping; Guo, Rui; Ming, Desong; Huang, Lv-ye; Su, Milong; Deng, Yiming; Wang, Qisheng

doi:10.1016/j.diagmicrobio.2013.04.026

Cited by 35 publications

(33 citation statements)

References 29 publications

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“…Moreover, we found that compared with CLC patients, the TGF‐β1 level was significantly increased in DCLC patients. This result supported the previous report that the level of TGF‐β1 was higher in severe CHB patients than that of low to moderate CHB patients . Above results suggested that we can modulate the TGF‐β1/IL‐17 or TGF‐β1/anti‐TGF‐β1 pathway to regulate the immune process of HBV‐LC so as to achieve the purpose of immunotherapy.…”

Section: Discussionsupporting

confidence: 90%

Ratios of regulatory T cells/T‐helper 17 cells and transforming growth factor‐β1/interleukin‐17 to be associated with the development of hepatitis B virus‐associated liver cirrhosis

Guo

Ming

et al. 2014

J of Gastro and Hepatol

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Background and Aim The aim of this study is to evaluate the association of the regulatory T cells (Treg)/T‐helper (Th) 17 cells and transforming growth factor‐β1 (TGF‐β1)/interleukin‐17 (IL‐17) ratios with the survival and disease progression in patients with hepatitis B virus (HBV)‐associated liver cirrhosis (LC). Methods The frequencies of Treg and Th17 cells were analyzed in 28 patients with HBV‐LC, 70 patients with chronic hepatitis B (CHB) and 20 normal controls (NC) by flow cytometry. The levels of cytokines related to Treg/Th17 differentiation, including IL‐10, TGF‐β1, IL‐17, and IL‐23, were measured by ELISA. Results Compared with NC, Treg cells were significantly increased in CHB patients and slightly increased in HBV‐LC patients, whereas Th17 cells were markedly increased both in patients with CHB and HBV‐LC. HBV‐LC patients, especially the nonsurvival ones, manifested a profound decrease in the Treg/Th17 ratio, which was negatively correlated with Child‐Pugh and model of end‐stage liver disease scores. Serum IL‐10, TGF‐β1, IL‐17, and IL‐23 levels were all significantly higher in HBV‐LC patients than in NC. In addition, the TGF‐β1/IL‐17 ratio was also markedly increased in patients with HBV‐LC, especially in nonsurvival and decompensated liver cirrhosis patients, and positively correlated with total bilirubin, Child‐Pugh, and model of end‐stage liver disease scores. Conclusions The decreased Treg/Th17 ratio and increased TGF‐β1/IL‐17 ratio may be associated with the survival and disease progression in HBV‐LC patients, and both of the two ratios can be used independently to predict the prognosis and disease progression of HBV‐LC patients.

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Section: Discussionsupporting

confidence: 90%

Ratios of regulatory T cells/T‐helper 17 cells and transforming growth factor‐β1/interleukin‐17 to be associated with the development of hepatitis B virus‐associated liver cirrhosis

Guo

Ming

et al. 2014

J of Gastro and Hepatol

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“…The Th2 immunity response is associated with the chronicity of HBV infection and it is well known that the imbalance of the Th1/Th2 immune response is reflected by an imbalance of cytokines and is one of the important factors affecting the clearance of viruses which ultimately lead to the chronicity of the infection2122. Our study showed that concentrations of cytokines in patients with CHB were significantly higher than normal control subjects, which implies that after the infection of HBV, the immune system is activated and the Th1/Th2 balance is re-established through high cytokine levels2023.…”

Section: Discussionmentioning

confidence: 49%

Slow reduction of IP-10 Levels predicts HBeAg seroconversion in chronic hepatitis B patients with 5 years of entecavir treatment

Guo

Mao

et al. 2016

Sci Rep

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The aim of this study was to determine the correlation between dynamic changes in serum cytokine/chemokine expression levels in response to entecavir (ETV) treatment and HBV e antigen (HBeAg) seroconversion in patients with chronic hepatitis B (CHB). Four cytokines (interleukin [IL]-4, IL-6, IL-8, and interferon-γ) and five chemokines (macro-phage inflammatory protein [MIP]-1α, MIP-1β, platelet derived growth factor-BB, and interferon-inducible protein 10 [IP-10]) before ETV therapy and at 3, 6, 12, 24, 36 and 60 months during therapy in 105 CHB patients were analyzed. The results showed that the low decrease rate of IP-10 levels after 1 year of ETV treatment was an independent predictor of HBeAg seroconversion at year 5 (Hazard ratio = 0.972). The area under the receiver operating characteristic curves for the decrease rate of IP-10 levels after 1 year of treatment to discriminate a year-5 HBeAg seroconversion was 0.752 (p = 0.005). The results indicate that higher IP-10 level at year one of ETV treatment is associated with an increased probability of HBeAg seroconversion. Quantification of IP-10 during ETV treatment may help to predict long-term HBeAg seroconversion in patients with CHB.

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“…However, the number of FoxP3 ϩ cells was decreased. The balance between Th17 and Treg cells mediates T cell activation (35,36), and this mechanism plays an important role in modulating T cell activation in hepatitis. The shift in the Th17/Treg balance could contribute to the T cell activation observed in Saa1 TG mice.…”

Section: Discussionmentioning

confidence: 99%

Hepatic Serum Amyloid A1 Aggravates T Cell-mediated Hepatitis by Inducing Chemokines via Toll-like Receptor 2 in Mice

Kim

Bae

et al. 2015

Journal of Biological Chemistry

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Background: Serum amyloid A is expressed in the liver in acute-phase inflammation. Results: Saa1 regulates the expression of chemokines and activation of T cells in T cell-mediated hepatitis. Conclusion: Overexpression of Saa1 aggravates hepatitis via the induction of chemokine expression by the TLR2 signaling pathway. Significance: Saa1 might be a novel inflammatory factor as a chemokine modulator in hepatitis.

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Changes in the balance between Treg and Th17 cells in patients with chronic hepatitis B

Cited by 35 publications

References 29 publications

Ratios of regulatory T cells/T‐helper 17 cells and transforming growth factor‐β1/interleukin‐17 to be associated with the development of hepatitis B virus‐associated liver cirrhosis

Ratios of regulatory T cells/T‐helper 17 cells and transforming growth factor‐β1/interleukin‐17 to be associated with the development of hepatitis B virus‐associated liver cirrhosis

Slow reduction of IP-10 Levels predicts HBeAg seroconversion in chronic hepatitis B patients with 5 years of entecavir treatment

Hepatic Serum Amyloid A1 Aggravates T Cell-mediated Hepatitis by Inducing Chemokines via Toll-like Receptor 2 in Mice

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