Changes in platelet morphology indices in relation to duration of disease and glycemic control in children with type 1 diabetes mellitus

Venkatesh, Vybhav; Kumar, Rakesh; Varma, Dinesh; Bhatia, Prateek; Yadav, Jaivinder; Dayal, Devi

doi:10.1016/j.jdiacomp.2018.06.008

Cited by 20 publications

(24 citation statements)

References 23 publications

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“…Sharpe et al [11] determined a significant increase in MPV values in patients with T1DM compared to healthy controls. Venkatesh et al [12] determined a significant increase in MPV values in subjects with childhood T1DM compared to a control group. Various different studies have thus suggested that platelets can be used as a marker for predicting an increase in the risk of the micro-and macrovascular complications of diabetes [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

“…PCT is assumed to show the number of platelets in circulation in one unit volume, and expresses platelet variation and heterogeneity [25]. There have been few studies of PCT values in diabetic cases, although Venkatesh et al [12] found no significant difference in terms of PCT values between children diagnosed with T1DM and a control group. Another study of patients with T2DM determined higher PCT values than in a control group.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of the Platelet Parameters in Children With Type 1 Diabetes Mellitus

Korkmaz¹

2018

J Endocrinol Metab

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Background: The purpose of this study was to assess platelet morphological parameters in children and adolescents with type 1 diabetes mellitus (T1DM) and to determine the factors affecting those parameters. Methods: A total of 80 children with type 1 diabetes mellitus and 80 healthy control subjects were included in this study. All subjects' platelet parameters including platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW) and plateletcrit (PCT) levels were measured. Age at diagnosis, duration of diabetes, and hemoglobin A1c (HbA1c) levels of patients with T1DM were also recorded. Results: There was no significant difference in PLT, MPV, PDW and PCT values between patients and controls (P > 0.05). PCT and PLT values were higher in patients with poor metabolic control compared to the other cases (P = 0.002, P = 0.005). Positive correlation was found between HbA1c and PCT (r = 0.28, P = 0.01). There was no correlation between HbA1c and MPV, PDW and PLT. Conclusions: Indices of platelet morphology such as PCT, PLT, PDW and MPV were similar in children with T1DM and in healthy controls. However, an increase in PCT values in poor glycemic control group and a significant positive correlation between PCT and HbA1c were observed, suggesting that PCT levels may be an early marker of vascular complication.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Assessment of the Platelet Parameters in Children With Type 1 Diabetes Mellitus

Korkmaz¹

2018

J Endocrinol Metab

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“…38 The abnormalities of platelets in DM are characterized to be hyperactive with increased autophagy, activation, adhesion and aggregation. [39][40][41][42][43] These abnormalities in platelets lead to wound healing dysfunction. Strategies using functional platelets and the combination of their secretions exhibit significant outcomes in managing wounds in DM.…”

Section: Dm Affects the Function Of Platelets In Wound Healingmentioning

confidence: 99%

Magnetic fields as a potential therapy for diabetic wounds based on animal experiments and clinical trials

Liu

Zhen

et al. 2021

Cell Proliferation

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“…Birçok klinisyen hemogram yorumlanmasında MPV değerlerini dikkate almamaktadır. Ancak güncel literatür incelendiğinde MPV değerinin sepsis, inflamatuar durumlar, kardiyovasküler hastalık riski, venöz tromboembolizm ve diabet gibi bazı hastalıklarda tanısal faydası olabileceği belirtilmektedir [2][3][4][5].…”

Section: Introductionunclassified

Does body mass index affect mean platelet volume in childhood and adolescence?

Karakurt

Kendırcı

2019

Turkish Journal of Clinics and Laboratory

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Öz Amaç: Çocukluk çağındaki obezite ile ortalama platelet volümünün (MPV) ilişkisini araştıran çalışmalar daha çok adölesan dönemi içermektedir. Daha küçük yaştaki çocuklardaki obezitenin MPV'ye etkisi ve yaşa göre zayıf hastalarda MPV değişiklikleri tanımlanmamıştır. Bu çalışmanın birinci sonlanım noktası obez, yaşa göre normal ve düşük VKİ'ne sahip çocuk ve adölesanlarda MPV değerlerinin incelenmesidir. Gereç ve Yöntemler: Üç yıllık hastane verilerinden yararlanılarak çocuk endokrinoloji polikliniğine başvuran hastaların dosyaları retrospektif incelendi. Hastalar vücut kitle indekslerine göre obes, normal ve zayıf olarak gruplara ayrıldı. Grupların MPV değerleri kıyaslandı. Bulgular: Çalışmaya dahil olan 261 çocuğun yaş ortalamaları 11,2± 3,7 (min:1,0, max:17,8) olup %37,9 'u (n=99) obez, %27,6'sı (n=72) yaşa göre zayıf, %34,5 'i (n=90) ise normal ağırlıkta (kontrol grubu) bulundu. Tüm hastaların hemoglobin ve MPV değerleri normal aralıkta olup obez ve kontrol gruplarında yaşa göre zayıf gruba göre yüksek bulundu. Ayrıca insülin direnci olan/ olmayanlar arasında da MPV değerleri arasına istatistiksel olarak anlamlı bir fark tespit edilemedi. Sonuç: Çalışmamızda literatürden farklı olarak MPV değerinin zayıf çocuklarda normal kiloda ve obez olanlara göre düşük, ancak hepsinde de normal aralıkta olduğunu saptadık. İnsülin direncinin MPV değerlerine etkisi olmadığını gösterdik. MPV değerlerinin klinik uygulamalarda yeri ile ilgili daha çok çalışmaya ihtiyaç vardır.

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Changes in platelet morphology indices in relation to duration of disease and glycemic control in children with type 1 diabetes mellitus

Cited by 20 publications

References 23 publications

Assessment of the Platelet Parameters in Children With Type 1 Diabetes Mellitus

Assessment of the Platelet Parameters in Children With Type 1 Diabetes Mellitus

Magnetic fields as a potential therapy for diabetic wounds based on animal experiments and clinical trials

Does body mass index affect mean platelet volume in childhood and adolescence?

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