Changes in plasma levels of adhesion molecules after percutaneous mitral balloon valvuloplasty

Changes in Platelet, Coagulation, and Fibrinolytic Activities in Mitral Stenosis After Percutaneous Mitral Valvotomy

“…They assumed this to either increased shear stress and/or smoldering immunological activity in these patients. 8 Changes in the levels of circulating soluble adhesion molecules has been reported after PMV with a decreased E-selectin 24 hours after the procedure 8 and vascular cell adhesion molecule 1 one week after. 7 The relationship between the inflammatory markers and the hemostatic changes has not been studied before.…”

“…3,5,6 Several reports have demonstrated elevated inflammatory markers in patients with MS having evidence of decreased levels of some these markers after PMV. [7][8][9] The cause of change in these markers by PMV is not clear. A relationship between high-sensitivity C-reactive protein as a marker of persistent inflammation and the PMV procedural success rate has been reported.…”

Rheumatic mitral valve stenosis is associated with impaired flow-mediated dilatation

“…It has been suggested that activated valvular endothelium play a role in the initial development of rheumatic valvulitis and the progression of the disease throughout a lifetime [2]. Nevertheless, it was also shown that patients with rheumatic mitral valve stenosis (RMVS) have increased concentrations of cytokines such as von Willebrand factor [3], vascular cell adhesion molecule-1 [4][5][6], intercellular adhesion molecule-1 [4,5] and endothelin-1 [7][8][9] which, when elevated, are also markers of vascular endothelial dysfunction. Thus, we aimed to assess and compare vascular endothelial function in patients with RMVS by using the noninvasive, ultrasound guided technique which evaluates flow-mediated dilatation (FMD) of the brachial artery.…”

“…Under these conditions cardiac myocytes might react as sensors and creates a persistent signal which generates a complex localized and systemic response with neurohomoral and cytokine production. Accordingly, studies have shown that the concentration of von Willebrand factor [3], E-selectin [5], P-selectin [12] vascular cell adhesion molecule-1 [4][5][6], intercellular adhesion molecule-1 [4,5] endothelin-1 [7][8][9], tumor necrosing factor-α and interleukin-6 [12] were elevated in patients with RMVS. Elevation of these factors are thought to reflect vascular endothelial dysfunction.…”

Percutaneous balloon commissurotomy reduces incidence of ischemic cerebral stroke in patients with symptomatic rheumatic mitral stenosis

“…This study displaying a significant benefit of BMC to the risk of ischemic stroke and an even greater favor of this procedure on the composite endpoint of systemic embolism (2% vs. 15%, p = 0.001, Table 2) firmly provided the evidence that BMC could effectively reduce thromboembolic complications. The mechanism for BMC to alleviate ischemic stroke risk remains unclear, but correction of coagulation disorders, [6] modulation of platelet activity, [7] and reduction of adhesion molecule levels [8] might possibly be attributable. As chronic AF and anticoagulant usage also closely correlated with ischemic stroke besides BMS, it could not be overemphasized that aggressive anticoagulation be considered for all patients with RMS, especially when comorbid with chronic AF.…”