Changes in metal levels and chromosome aberrations in the peripheral blood of patients after metal-on-metal hip arthroplasty

Melanoma Epidemiology and Prevention

“…Case and colleagues [122] conducted extensive studies in patients, and these have led to the following general observations [122,132]: (1) Cr(VI) and cobalt (Co) were shed into the bloodstream of patients with prior metal-on-metal hip arthroplasties, but not in non-metal or knee arthroplasties (in which there is no direct metal-metal contact). (2) The concentration of Cr(VI) in the blood of these patients peaked at 6-12 years at 10 times "normal" levels and was measurable up to 10 years later.…”

Metal-on-metal hip resurfacing arthroplasty: A review of periprosthetic biological reactions

“…Under stimulation by Co 2+ or Cr 6+ , both of these repair mechanisms are inhibited (Witkiewicz-Kucharczyk and Bal 2006). Ladon et al (2004) investigated changes in metal ion levels and chromosome aberrations in patients within 2 years of receiving MoM hip arthroplasties. The authors noted an increase in chromosome translocations and aneuploidy in peripheral blood lymphocytes at 6, 12, and 24 months after surgery.…”

“…The potential effects of elevated levels of metal particles and ions are poorly defined, but they may lead to adverse biological reactions including local soft tissue toxicity, hypersensitivity reactions, bone loss, and risk of carcinogenesis (Gillespie et al 1996, Willert et al 2005, Keegan et al 2007, Lidgren 2008. There is also concern about chromosomal aberrations in the patient, as well as the risk of passing chromosomal abnormalities to the next generation (Case et al 1996, Doherty et al 2001, Ladon et al 2004, Brodner et al 2004a, Papageorgiou et al 2007, Ziaee et al 2007 In this review we present the available evidence on adverse periprosthetic biological reactions in patients with the MoM hip resurfacing arthroplasty. The possible role of the metal particle-induced immunological and cellular responses in the pathogenesis of adverse periprosthetic reactions is outlined.…”

The Effect Of Different Bearing Surfaces On Metal Ion Levels In Urine Following 28 Mm Metal-On-Metal And 28 Mm Metal-On-Polyethylene Total Hip Arthroplasty

“…There has been concern that MOM bearings may pose a higher risk of malignant degeneration because of an increased exposure to metal particles and ions (17). Recent studies have raised the possibility of increased DNA (18) and chromosomal changes (19) occurring in patients with both MOM and non-MOM devices (19). As MOM bearings are used in young patients, there is concern that mutagenic or teratogenic effects could be manifest in children conceived by these patients.…”