Changes in lipid metabolism during last month of pregnancy and first two months of lactation in primiparous cows – analysis of apolipoprotein expression pattern and changes in concentration of total cholesterol, HDL, LDL, triglycerides

Kurpińska, Anna; Jarosz, Agnieszka; Ożgo, M.; Skrzypczak, W. F.

doi:10.1515/pjvs-2015-0038

Cited by 24 publications

(21 citation statements)

References 28 publications

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“…The pathogen isolation rate increased 2.1% per unit (mg dL -1 ) increase in serum tryglicerides. Interestingly, Kushibiki et al (2002) studied the effect of tumor necrosis factor-alpha (TNF-α) on the lipid metabolism of heifers, and they observed that infusion with recombinant TNF-α quickly increased their trygliceride concentrations 0.5 hours after infusion. Regarding that, TNF-α plays a key role in regulating an inflammatory immune response, and it mediates hypertriglyceridemia in response to infection (Bradford et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Mastitis in the transition period: identification of potential blood markers

Santos

Souza

Blagitz

et al. 2018

Arq. Bras. Med. Vet. Zootec.

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This study identified potential blood markers associated with mastitis in dairy cows under different dry therapies during the transition period, using a logistic regression model. Thirty-four Holstein dairy cows were divided into three groups: untreated controls (13 cows, 42 quarters); animals that received an antimicrobial at drying-off (10 cows, 40 quarters); and animals that were administered an internal teat sealant at drying-off (11 cow, 44 quarters). Blood and quarter milk samples were collected 60 days before the expected day of calving, on the day of calving, and three, seven, 15, 21, and 30 days after calving. Milk samples were submitted for bacteriological analysis and somatic cell count. Blood samples were collected for analyses of the following: the erythrogram and leucogram; plasm fibrinogen concentration; hepatic and renal functions; metabolic profile; serum calcium and phosphorous levels; total serum protein and albumin concentrations. The concentration of total serum proteins was associated with a high somatic cell count. Similarly, the concentrations of total serum proteins and triglycerides were associated to milk bacteriological positive samples during the transition period. Thus, the occurrence of mastitis in dairy cows during the transition period was greater in animals that showed higher concentrations of serum total proteins and triglycerides, in contrast to the use of dry cow therapy.

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Section: Discussionmentioning

confidence: 99%

Mastitis in the transition period: identification of potential blood markers

Santos

Souza

Blagitz

et al. 2018

Arq. Bras. Med. Vet. Zootec.

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“…The function of cholesterol is to build cell membranes and to produce different hormones essential for proper body functions such as estrogen, progesterone and aldosterone (Ahmad et al, 2004). By assessing the parameters such as the total cholesterol, HDL (High density lipoprotein), LDL (Low density lipoprotein) and triglycerides (TG), variations in lipid metabolism occurring in lactating cows could be better understood (Kurpińska et al, 2015). Aspartate transaminase (AST), Alanine transaminase (ALT) and Gamma-glutamyltransferase (GGT) are serum enzymes commonly found in the liver tissues and are considered as biological health markers in case of hepatic disorders and other health issues (Boonprong et al, 2007;Lim et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Management of blood lipid profile and oxidative status in Holstein and Simmental dairy cows during lactation

et al. 2019

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Managing and determination of the blood lipid profile and oxidative status are useful tool to show the influence of foreign chemical substances on production of dairy cows. Investigation of various biomarkers of oxidative stress related to various problems in the production dairy cows presents a very important issue. The aim of this research was to investigate different biological markers in two different breeds of dairy cows – the Holstein Friesian and the Simmental, during different stages of lactation. The total of 60 Holstein Friesian and Simmental cows were divided into two treatments (HF and S) which was further divided into three groups each, respectively. Lactating groups of each cow breed was divided into three stages at early lactation of 32-75 days (HF1 and S1), peak lactation of 80-165 days (HF2 and S2) and low lactation of 175 days onward (HF3 and S3). During the research the total milk production and the percentage of milk fat and protein were determined. Blood samples were collected from jugular vein of each cow, the serum was harvested without anticoagulant and stored at -20 °C in small aliquots till further analysis. Serum was then analyzed for triglyceride, cholesterol, HDL, LDL, AST, ALT, GGT, the total antioxidant status (TAS), the total oxidant status (TOS), MDA, SOD, catalase and paraoxonase (PON1). Significantly (P<0.05) higher values of cholesterol, TOS and SOD at peak lactation stage was observed in all cows. A gradual decline from early lactation to low lactation was observed in the values of triglycerides and ALT, while MDA gradually increased from the same stage in all cows. The values of LDL and catalase showed an irregular pattern of variations in various lactation stages among all groups. The Holstein Friesian breed showed significantly higher values of ALT and PON1, while values of HDL, TAS and TOS were the lowest in Simmental group (P<0.05). By measuring the signs of oxidative stress, it was concluded that metabolic efforts of cows during the peak of lactation affected the investigated parameters. Disturbance in feed intake and rise in metabolic processes lift up oxidative stress in cows, especially during the peak of lactation, which might be determined by monitoring blood alterations. Results of our study indicated that the Holstein Friesian breed was under higher oxidative stress during different lactation stages compared to Simmental dairy cows.

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“…Furthermore, triglycerides (TAG) and NEFA are both associated with fatty liver (Bobe et al 2004) and an increase in postpartum liver TAG concentrations is accompanied by an increase in plasma NEFA concentrations (van den Top et al 1995). Besides cholesterol and TAG, high-density lipoproteins (HDL) are related to the lipid metabolism during the transition period (Kurpinska et al 2015).…”

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confidence: 99%

Associations of β-hydroxybutyrate, cholesterol, triglycerides and high-density lipoproteins to non-esterified fatty acids pre- and postpartum

Ruoff

Bertulat

Burfeind

et al. 2016

Journal of Dairy Research

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While laboratory tests for measuring the concentration of NEFA in serum are well established, a point of care test to determine NEFA on farm is not available. Several hand-held measuring devices, however, have been validated for measuring β-hydroxybutyrate (BHBA) in cattle or cholesterol, triglycerides (TAG), and high-density lipoproteins (HDL) in human medicine, respectively. The objective of this study was to evaluate the association between NEFA and different parameters related to lipid metabolism. Specifically, we set out to determine if it is feasible to predict the concentration of NEFA by means of surrogate measures. The concentration of BHBA was determined by a hand-held device evaluated for use in cows, whereas the concentrations of the other parameters were determined by laboratory analysis because hand-held devices for cholesterol, TAG and HDL are only evaluated for human medicine so far. A total of 254 cows were included in the trial. One blood sample was taken from each cow between d 10 and d 1 prepartum. Second and third samples were collected on d 2 and d 10 postpartum, respectively. The coefficients of correlation between parameters were calculated and a receiver-operator characteristic curve analysis has been used. The prediction of NEFA concentrations using only one of the parameters was insufficient. However, a NEFA concentration ≥0·5 mEq/l could be predicted with a high sensitivity (i.e. Se = 0·88) and specificity (i.e. Sp = 0·93) from d 3 to d 1 prepartum and a NEFA concentration ≥0·7 mEq/l could be reliably predicted on d 2 postpartum (i.e. AUC = 0·89, Se = 0·89, Sp = 0·76) when using a combination of BHBA, cholesterol and TAG as surrogates. Overall, our results suggest that a combination of different parameters of lipid metabolism could be used as surrogates for NEFA.

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Changes in lipid metabolism during last month of pregnancy and first two months of lactation in primiparous cows – analysis of apolipoprotein expression pattern and changes in concentration of total cholesterol, HDL, LDL, triglycerides

Cited by 24 publications

References 28 publications

Mastitis in the transition period: identification of potential blood markers

Mastitis in the transition period: identification of potential blood markers

Management of blood lipid profile and oxidative status in Holstein and Simmental dairy cows during lactation

Associations of β-hydroxybutyrate, cholesterol, triglycerides and high-density lipoproteins to non-esterified fatty acids pre- and postpartum

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