Changes in <i>Notch</i> signaling coordinates maintenance and differentiation of the <i>Drosophila</i> larval optic lobe neuroepithelia

Weng, Mo; Haenfler, Jill M.; Lee, Cheng-Yu

doi:10.1002/dneu.20995

Cited by 29 publications

(51 citation statements)

References 30 publications

(53 reference statements)

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“…E(spl)md, E(spl)m7, and Tom are direct targets of the Notch pathway (Bray 2006), while H is a transcription corepressor involved in repression of Notch signaling activity (Bang et al 1995). The Notch pathway is required for neuroepithelial maintenance and expansion (Egger et al 2010;Ngo et al 2010;Reddy et al 2010;Yasugi et al 2010;Orihara-Ono et al 2011;Wang et al 2011b;Weng et al 2012). Our microarray data support a model in which JAK/STAT acts upstream of Notch signaling in the optic lobe (Wang et al 2011a).…”

Section: Discussionsupporting

confidence: 69%

Evidence for Tissue-Specific JAK/STAT Target Genes inDrosophilaOptic Lobe Development

et al. 2013

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The evolutionarily conserved JAK/STAT pathway plays important roles in development and disease processes in humans. Although the signaling process has been well established, we know relatively little about what the relevant target genes are that mediate JAK/STAT activation during development. Here, we have used genome-wide microarrays to identify JAK/STAT targets in the optic lobes of the Drosophila brain and identified 47 genes that are positively regulated by JAK/STAT. About two-thirds of the genes encode proteins that have orthologs in humans. The STAT targets in the optic lobe appear to be different from the targets identified in other tissues, suggesting that JAK/STAT signaling may regulate different target genes in a tissue-specific manner. Functional analysis of Nop56, a cell-autonomous STAT target, revealed an essential role for this gene in the growth and proliferation of neuroepithelial stem cells in the optic lobe and an inhibitory role in lamina neurogenesis.

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Section: Discussionsupporting

confidence: 69%

Evidence for Tissue-Specific JAK/STAT Target Genes inDrosophilaOptic Lobe Development

et al. 2013

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“…Another example of the association of neurogenesis with a particular cell cycle stage in Drosophila can be found in the neural precursors from the outer optic anlagen. This structure gives rise to the outer part of the medulla and lamina of the optic lobes, and their constituting neuroepithelial cells require to be in G1 to progress from neuroepithelial cells to neuroblasts (Reddy et al, 2010), concomitant with an increase of Notch activity that facilitates the neuroblast fate selection (Weng et al, 2012). Forcing cell cycle progression in the neuroepithelial cells with cell cycle regulators such as cyclin D, cdk4, E2F1 and DP has been shown to lead to a differentiation delay with a concomitant prevention of Dl expression (Reddy et al, 2010).…”

Section: The Neurogenic Capacity Of Neural Precursors Is Linked To Spmentioning

confidence: 99%

Lateral inhibition and neurogenesis: novel aspects in motion

Formosa-Jordan¹,

Ibañes²,

Ares³

et al. 2013

Int. J. Dev. Biol.

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Neuronal production in metazoans is tightly controlled by Delta/Notch-dependent signals regulating lateral inhibition. It is currently thought that lateral inhibition takes place in clusters of precursors with equal capacity to trigger and receive Notch-dependent inhibitory signals. However, this view neglects crucial dynamical aspects of the process. In this review, we discuss two of these dynamic factors, whose alterations yield dysfunctions in neurogenesis. First, precursors show variable neurogenic capacity as they go through the cell cycle. Second, differentiating precursors are in direct contact with non-neurogenic cells at the wavefront of expanding neurogenic domains. We discuss the mechanisms adopted by Metazoa to prevent these dysfunctions in the lateral inhibitory process, which include cell cycle synchronization occurring in the invertebrate neural epithelium and during primary neurogenesis in anamniotes, interkinetic nuclear movement in the vertebrate neuroepithelium and generalized Delta expression ahead of the neurogenic wavefront. The emerging concept is that lateral inhibition during neurogenesis occurs in dynamic clusters of precursors and requires specific mechanisms to avoid distortions resulting from the interaction between neurogenic and non-neurogenic precursors. The advance in visualizing Notch dynamics with real-time imaging at cellular and subcellular levels will notably contribute to our understanding of these novel "aspects of motion" in neurogenesis.

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“…3C-F9); it started to be highly expressed at the transition zone where the Notch ligand Dl is enriched in a characteristic punctuated pattern (Fig. 3C-D0) (Weng et al, 2012;Yasugi et al, 2010). L9sc is also very locally activated at the transition zone, in progenitor I (PI) and progenitor II (PII) cells; the latter juxtaposed to the emerging medulla NBs (Yasugi et al, 2010) ( Fig.…”

Section: Cno Colocalizes With Notch At the Ajs Of Ne Cellsmentioning

confidence: 94%

“…Notch signaling is required to regulate the progression of the proneural wave (Egger et al, 2010;Ngo et al, 2010;Reddy et al, 2010;Wang et al, 2011;Weng et al, 2012;Yasugi et al, 2010). Given that Cno and Notch functionally interact in other systems (Carmena et al, 2006;Miyamoto et al, 1995) and that cno mutant phenotypes were very reminiscent of those previously described for Notch mutants in the neuroepithelium (Yasugi et al, 2010), we decided to analyze the relative localization of Cno and Notch in the optic lobe.…”

Section: Cno Colocalizes With Notch At the Ajs Of Ne Cellsmentioning

confidence: 99%

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A Serrate-Notch-Canoe complex mediates glial-neuroepithelial cell interactions essential during Drosophila optic lobe development

Pérez-Gómez

Slováková

Rives-Quinto

et al. 2013

Journal of Cell Science

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It is firmly established that neuron-glia interactions are fundamental across species for the correct establishment of a functional brain. Here, we found that the glia of the Drosophila larval brain display an essential non-autonomous role during the development of the optic lobe. The optic lobe develops from neuroepithelial cells that proliferate by dividing symmetrically until they switch to asymmetric/differentiative divisions generating neuroblasts. The proneural gene lethal of scute (l'sc) is transiently activated by the Epidermal Growth Factor Receptor (EGFR)/Ras signal transduction pathway at the leading edge of a proneural wave that sweeps from medial to lateral neuroepithelium promoting this switch. This process is tightly regulated by the tissue-autonomous function within the neuroepithelium of multiple signaling pathways, including EGFR/Ras and Notch. This study shows that the Notch ligand Serrate (Ser) is expressed in the glia and it forms a complex in vivo with Notch and Canoe, which colocalize at the adherens junctions of neuroepithelial cells. This complex is crucial for glial-neuroepithelial cell interactions during optic lobe development. Ser is tissue-autonomously required in the glia where it activates Notch to regulate its proliferation, and non-autonomously in the neuroepithelium where Ser induces Notch signaling to avoid the premature activation of the EGFR/Ras pathway and hence of L'sc. Interestingly, different Notch activity reporters showed very different expression patterns in the glia and in the neuroepithelium, suggesting the existence of tissue-specific factors that promote the expression of particular Notch target genes or/and a reporter response dependent on different thresholds of Notch signaling.

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Changes in Notch signaling coordinates maintenance and differentiation of the Drosophila larval optic lobe neuroepithelia

Cited by 29 publications

References 30 publications

Evidence for Tissue-Specific JAK/STAT Target Genes inDrosophilaOptic Lobe Development

Evidence for Tissue-Specific JAK/STAT Target Genes inDrosophilaOptic Lobe Development

Lateral inhibition and neurogenesis: novel aspects in motion

A Serrate-Notch-Canoe complex mediates glial-neuroepithelial cell interactions essential during Drosophila optic lobe development

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