Changes in Gray Matter Volume and White Matter Microstructure in Adolescents with Obsessive-Compulsive Disorder

Clinical Motor and Cognitive Neurobehavioral Relationships in the Basal Ganglia

“…There is evidence of basal ganglia dysfunction from imaging studies of OCD, with both reduced and increased volumes of caudate nuclei reported [57][58][59]. Increased caudate metabolism has been found to be reduced after effective treatment of the OCD [60,61 and in provoked or activated conditions, patients with OCD have shown increased caudate blood flow [62.…”

Neuroimaging in autism spectrum disorder: brain structure and function across the lifespan

“…41 The amygdala is also signifi cantly enlarged in children with ASD compared with typically developing children. 42 However, enlargement of the basal ganglia has also been noted in individuals with obsessive-compulsive disorder without a comorbid diagnosis of ASD, 43 and increased total amygdala volume has been reported in children with general anxiety disorders. 44 Finally, frontal lobe abnormalities, which are a hallmark of ASD, have also been found in other neurodevelopmental disorders such as schizophrenia.…”

Sintomas obsessivo-compulsivos em escolares: prevalência, dimensões psicopatológicas, agregação familiar, comorbidades e fatores clínicos associados

“…Volumetric changes in gray matter of the frontal cortex and anterior cingulate gyri have been described in children. Those same alterations have been observed in adults, in both gray and white matters (80)(81)(82). It seems that children and adolescents with OCD present volumetric reduction of corpus callosum and pituitary and enlargement of the third ventricle, compared to controls (78).…”