2015
DOI: 10.1152/ajprenal.00144.2015
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Abstract: Kidney aging is accompanied by characteristic changes in the glomerulus, but little is known about the effect of aging on glomerular parietal epithelial cells (PECs), nor if the characteristic glomerular changes in humans and rats also occur in very old mice. Accordingly, a descriptive analysis was undertaken in 27-mo-old C57B6 mice, considered advanced age. PEC density was significantly lower in older mice compared with young mice (aged 3 mo), and the decrease was more pronounced in juxtamedullary glomeruli c… Show more

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Cited by 42 publications
(78 citation statements)
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“…39, 40 Rather, a subset begin to de novo express CD44, 1,4192223 a biological state called “activated” PECs. 3, 41 Activated PECs have been reported to distinguish FSGS from minimal change disease on human kidney biopsies.…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations
“…39, 40 Rather, a subset begin to de novo express CD44, 1,4192223 a biological state called “activated” PECs. 3, 41 Activated PECs have been reported to distinguish FSGS from minimal change disease on human kidney biopsies.…”
Section: Discussionmentioning
confidence: 99%
“…The rationale derives from our recent mouse studies in FSGS 21 and aged kidneys, 4 showing pERK1/2 and CD44 often co-localize in PECs. Co-localization of pERK1/2 and CD44 was validated in the current study.…”
Section: Discussionmentioning
confidence: 99%
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“…Compensatory hypertrophy of residual nonsclerotic glomeruli and their attached tubules (nephron hypertrophy) may explain the reduced glomerular density seen in renal biopsies with aging; however, causality should be inferred only from cross-sectional findings with caution. The precise mechanisms responsible for FGGS is also unknown, but animal experimentation and human studies suggest that visceral epithelial cell degeneration (apoptosis and detachment) and faulty replacement from parietal epithelial cells progenitors may be operating [17,18,19]. The resultant ‘podocytopenia' can also influence single nephron filtration rate (SNGFR), by altering hydraulic permeability or the surface area available for filtration [20].…”
Section: Changes In Gfr and Kidney Anatomy With Agingmentioning
confidence: 99%