Changes in endothelial cell-derived extracellular vesicles after acute exercise in patients with COPD: a pilot study

Nieri, Dario; Neri, Tommaso; Santerini, Sabrina; Lombardi, Stefania; Celi, Alessandro

doi:10.36416/1806-3756/e20200007

Cited by 1 publication

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References 9 publications

(11 reference statements)

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“…Both circulating endothelium-and monocyte-derived EVs levels progressively increased along with disease severity, evaluated by using airflow obstruction, symptoms and exacerbations history together in a single panel [38]; moreover, CD62E + EEVs showed a significant correlation with lung function decline over time [42] and with exacerbation susceptibility [35]. Finally, EEVs have also been proposed as markers of endothelial function under stress conditions (such as physical exercise), even though with discordant results [43,44].…”

Section: Circulating Extracellular Vesicles As Biomarkers In Peripher...mentioning

confidence: 99%

The Emerging Role of Extracellular Vesicles Detected in Different Biological Fluids in COPD

Neri

Celi

Tinè

et al. 2022

IJMS

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The pathogenesis of chronic obstructive pulmonary disease (COPD) is characterized by complex cellular and molecular mechanisms, not fully elucidated so far. It involves inflammatory cells (monocytes/macrophages, neutrophils, lymphocytes), cytokines, chemokines and, probably, new players yet to be clearly identified and described. Chronic local and systemic inflammation, lung aging and cellular senescence are key pathological events in COPD development and progression over time. Extracellular vesicles (EVs), released by virtually all cells both as microvesicles and exosomes into different biological fluids, are involved in intercellular communication and, therefore, represent intriguing players in pathobiological mechanisms (including those characterizing aging and chronic diseases); moreover, the role of EVs as biomarkers in different diseases, including COPD, is rapidly gaining recognition. In this review, after recalling the essential steps of COPD pathogenesis, we summarize the current evidence on the roles of EVs collected in different biological mediums as biomarkers in COPD and as potential players in the specific mechanisms leading to disease development. We will also briefly review the data on EV as potential therapeutic targets and potential therapeutic agents.

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Section: Circulating Extracellular Vesicles As Biomarkers In Peripher...mentioning

confidence: 99%

The Emerging Role of Extracellular Vesicles Detected in Different Biological Fluids in COPD

Neri

Celi

Tinè

et al. 2022

IJMS

Self Cite

View full text Add to dashboard Cite

show abstract

Changes in endothelial cell-derived extracellular vesicles after acute exercise in patients with COPD: a pilot study

Cited by 1 publication

References 9 publications

The Emerging Role of Extracellular Vesicles Detected in Different Biological Fluids in COPD

The Emerging Role of Extracellular Vesicles Detected in Different Biological Fluids in COPD

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