Changes in Continuous, Long-Term Heart Rate Variability and Individualized Physiological Responses to Wellness and Vacation Interventions Using a Wearable Sensor

Pratap, Abhishek; Steinhubl, Steve; Neto, Elias Chaibub; Wegerich, Stephan; Peterson, Christine Tara; Weiss, Lizzy; Chopra, Deepak; Mills, Paul J.

doi:10.3389/fcvm.2020.00120

Cited by 4 publications

(5 citation statements)

References 54 publications

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“…It was hypothesized that VVHRV reflects sympathetic overactivity, which may induce myocardial work and activate platelet, leading to several cardiovascular outcomes including thrombosis and arrhythmia ( 14 ). VVHRV was also believed to be linked with neurocardiac functions relates to autonomic nervous system, such as stress, autonomic balance, vascular tone, and blood pressure, which was proven to be associated with risks of cardiovascular events ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

Visit-to-Visit Heart Rate Variability Is Positively Associated With the Risk of Adverse Cardiovascular Outcomes

Zeng

Wang

Cheng

et al. 2022

Front. Cardiovasc. Med.

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IntroductionPrevious studies found visit-to-visit heart rate variability (VVHRV) may be positively associated with risks of several cardiovascular events, but whether VVHRV affected the benefit of intensive blood pressure control remained unknown. In this study, we assessed the risk of the composite cardiovascular outcomes associated with VVHRV among the older patients with hypertension and evaluated whether the benefit of intensive blood pressure control in the prevention of the composite cardiovascular outcomes was consistent in the context of elevated VVHRV.MethodsThis was a post-hoc analysis of the Systolic Blood Pressure Intervention Trial (SPRINT). We explored the relationship between VVHRV and the composite cardiovascular outcomes by multivariate Cox proportional hazard regressions. The primary endpoint was the composite cardiovascular outcomes, same as SPRINT, defined as a composite of myocardial infarction, stroke, heart failure, and/or death from cardiovascular causes. We used multiple adjustment models for all regressions.ResultsNine thousand two hundred and fourty-seven patients from the SPRINT were included in our analysis. We found a positive association between VVHRV and the risk of composite cardiovascular outcomes among the elderly with hypertension. Per 1 CV increment in HRCV, the hazard ratio of the risk of composite cardiovascular outcomes was 1.04 (95CI: 1.03, 1.05) in the fully adjusted Model. The benefit of intensive blood pressure control in managing cardiovascular events was consistent in different VVHRV subgroups. There was no significant interaction in other confounders.ConclusionWe found the VVHRV was associated with the composite cardiovascular outcomes among the elderly with hypertension, intensive blood pressure control did not change the above association, and the benefits of intensive blood pressure management were consistent across different VVHRV groups.

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Section: Discussionmentioning

confidence: 99%

Visit-to-Visit Heart Rate Variability Is Positively Associated With the Risk of Adverse Cardiovascular Outcomes

Zeng

Wang

Cheng

et al. 2022

Front. Cardiovasc. Med.

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“…The PPG stress biosensors focus on the changes in PPG waves 48 . As already mentioned, alterations in HRV values are used as an indication of the presence of stress in the body, and the PPG sensors provide a simple, easy‐to‐wear, and continuous monitoring of the HRV levels of an individual 49 . PPG measures the HRV using the phenomenon of light transmission and reflection.…”

Section: Machine Learningmentioning

confidence: 99%

“…48 As already mentioned, alterations in HRV values are used as an indication of the presence of stress in the body, and the PPG sensors provide a simple, easy-to-wear, and continuous monitoring of the HRV levels of an individual. 49 PPG measures the HRV using the phenomenon of light transmission and reflection. An LED light is emitted from the wearable sensor (the sensor is placed close to the area where arteries are more prominent) (Figure 12) that is reflected through the skin surface.…”

Section: Photoplethysmography (Ppg)mentioning

confidence: 99%

Uninterrupted real‐time cerebral stress level monitoring using wearable biosensors: A review

Mishra

Agrawal

Ali

et al. 2023

Biotech and App Biochem

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Stress is the major unseen bug for the health of humans with the increasing workaholic era. Long periods of avoidance are the main precursor for chronic disorders that are quite tough to treat. As precaution is better than cure, stress detection and monitoring are vital. Although there are ways to measure stress clinically, there is still a constant need and demand for methods that measure stress personally and in an ex vitro manner for the convenience of the user. The concept of continuous stress monitoring has been introduced to tackle the issue of unseen stress accumulating in the body simultaneously with being user‐friendly and reliable. Stress biosensors nowadays provide real‐time, noninvasive, and continuous monitoring of stress. These biosensors are innovative anthropogenic creations that are a combination of biomarkers and indicators like heart rate variation, electrodermal activity, skin temperature, galvanic skin response, and electroencephalograph of stress in the body along with machine learning algorithms and techniques. The collaboration of biological markers, artificial intelligence techniques, and data science tools makes stress biosensors a hot topic for research. These attributes have made continuous stress detection a possibility with ease. The advancement in stress biosensing technologies has made a great impact on the lives of human beings so far. This article focuses on the comprehensive study of stress‐indicating biomarkers and the techniques along with principles of the biosensors used for continuous stress detection. The precise overview of wearable stress monitoring systems is also sectioned to pave a pathway for possible future research studies.

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“…Digital symptom monitoring can potentially affect the course of treatment, but such data are often not fed back to patients (or sometimes even clinicians) to guide treatment decisions [ 11 ]. Both provider and patient engagement are necessary to overcome the poor utilization that has been apparent in clinics, among the public, and even in more highly controlled digital health studies [ 12 , 13 ].…”

Section: The Unrealized Potential Of Digital Measurement In Behavioral Healthmentioning

confidence: 99%

Beyond the Therapist’s Office: Merging Measurement-Based Care and Digital Medicine in the Real World

Chiauzzi¹,

Wicks

2021

Digit Biomark

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This viewpoint focuses on the ways in which digital medicine and measurement-based care can be utilized in tandem to promote better assessment, patient engagement, and an improved quality of psychiatric care. To date, there has been an underutilization of digital measurement in psychiatry, and there is little discussion of the feedback and patient engagement process in digital medicine. Measurement-based care is a recognized evidence-based strategy that engages patients in an understanding of their outcome data. When implemented as designed, providers review the scores and trends in outcome immediately and then provide feedback to their patients. However, the process is typically confined to office visits, which does not provide a complete picture of a patient’s progress and functioning. The process is labor intensive, even with digital feedback systems, but the integration of passive metrics obtained through wearables and apps can supplement office-based observations. This enhanced measurement-based care process can provide a picture of real-world patient functioning through passive metrics (activity, sleep, etc.). This can potentially engage patients more in their health data and involve a critically needed therapeutic alliance component in digital medicine.

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Changes in Continuous, Long-Term Heart Rate Variability and Individualized Physiological Responses to Wellness and Vacation Interventions Using a Wearable Sensor

Cited by 4 publications

References 54 publications

Visit-to-Visit Heart Rate Variability Is Positively Associated With the Risk of Adverse Cardiovascular Outcomes

Visit-to-Visit Heart Rate Variability Is Positively Associated With the Risk of Adverse Cardiovascular Outcomes

Uninterrupted real‐time cerebral stress level monitoring using wearable biosensors: A review

Beyond the Therapist’s Office: Merging Measurement-Based Care and Digital Medicine in the Real World

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