Changes in choline and cholinesterase in saliva of dogs with parvovirus infection

Kocatürk, Meriç; Tecles, Fernando; Yalçın, Ebru; Cihan, Hüseyin; Tural, Merve; Levent, Pinar; Cansev, Mehmet; Cerón, José J.; Yılmaz, Zeki

doi:10.1016/j.rvsc.2020.12.012

Research in Veterinary Science

2021

DOI: 10.1016/j.rvsc.2020.12.012

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Changes in choline and cholinesterase in saliva of dogs with parvovirus infection

Meriç Kocatürk

Fernando Tecles

Ebru Yalçın

et al.

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2024

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Emerging significance of butyrylcholinesterase

Sridhar,

Gumpeny

2024

World J Exp Med

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Butyrylcholinesterase (BChE; EC 3.1.1.8), an enzyme structurally related to acetylcholinesterase, is widely distributed in the human body. It plays a role in the detoxification of chemicals such as succinylcholine, a muscle relaxant used in anesthetic practice. BChE is well-known due to variant forms of the enzyme with little or no hydrolytic activity which exist in some endogamous communities and result in prolonged apnea following the administration of succinylcholine. Its other functions include the ability to hydrolyze acetylcholine, the cholinergic neurotransmitter in the brain, when its primary hydrolytic enzyme, acetylcholinesterase, is absent. To assess its potential roles, BChE was studied in relation to insulin resistance, type 2 diabetes mellitus, cognition, hepatic disorders, cardiovascular and cerebrovascular diseases, and inflammatory conditions. Individuals who lack the enzyme activity of BChE are otherwise healthy, until they are given drugs hydrolyzed by this enzyme. Therefore, BChE is a candidate for the study of loss-of-function mutations in humans. Studying individuals with variant forms of BChE can provide insights into whether they are protected against metabolic diseases. The potential utility of the enzyme as a biomarker for Alzheimer’s disease and the response to its drug treatment can also be assessed.

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Emerging significance of butyrylcholinesterase

Sridhar,

Gumpeny

2024

World J Exp Med

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Changes in choline and cholinesterase in saliva of dogs with parvovirus infection

Cited by 1 publication

References 21 publications

Emerging significance of butyrylcholinesterase

Emerging significance of butyrylcholinesterase

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