Cell Reports volume 5, issue 4, P909-917 2013 DOI: 10.1016/j.celrep.2013.10.012 View full text
Michael D. Barnhart, Stephanie L. Moon, Alexander W. Emch, Carol J. Wilusz, Jeffrey Wilusz

Abstract: Summary The impact of RNA viruses on the post-transcriptional regulation of cellular gene expression is unclear. Sindbis virus causes a dramatic relocalization of the cellular HuR protein from the nucleus to the cytoplasm in infected cells. This is due to the expression of large amounts of viral RNAs that contain high affinity HuR binding sites in their 3’ UTRs effectively serving as a sponge for the HuR protein. Sequestration of HuR by Sindbis virus is associated with destabilization of cellular mRNAs that n…

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