Changes in C-reactive protein and erythrocyte sedimentation rate after hip fractures

Ellitsgaard, Niels; Andersson, Anders P.; Jensen, Kim Ebensgaard; Jørgensen, Morten

doi:10.1007/bf00186867

Cited by 39 publications

(20 citation statements)

References 11 publications

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“…Previous studies (Ellitsgaad et al 1991, Choudhry et al 1992, Kragsbjerg et al 1995 have reported that CRP levels depend on the region of trauma, with the maximum levels on the second postoperative day. Reliable data exist for hip fractures (Okafor and Maclellan 1998) and arthroplasty of the hip (Niskanen et al 1996, White et al 1998, reaching values of about 10-16 mg/dL for standard procedures, using a posterolateral or anterolateral approach.…”

Section: Discussionmentioning

confidence: 91%

C-reactive protein as a parameter of surgical trauma: CRP response after different types of surgery in 349 hip fractures

Metak²,

2006

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Background Postoperative C-reactive protein (CRP) levels in serum appear to reflect surgical trauma. We examined CRP levels after different types of surgery in hip fractures.Methods We studied the CRP response after 349 operative procedures in proximal femur fractures with a normal postoperative course. 5 different operative techniques were used: 3-4 percutaneous cancellous screws, dynamic hip screw (DHS), proximal femur nail (PFN), hemiarthroplasty (HA), and total hip arthroplasty (THA).Results Peak CRP levels were reached on the second postoperative day in each group (medians: screws 8.7, DHS 12, PFN 14, HA 16, THA 16 mg/dL). Significant differences were found between screws and all others, and between DHS and arthroplasties.Interpretation CRP levels following surgical trauma can be used to quantify the degree of tissue damage and invasiveness of a procedure and reflect the perioperative stress experienced by the patient.

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Section: Discussionmentioning

confidence: 91%

C-reactive protein as a parameter of surgical trauma: CRP response after different types of surgery in 349 hip fractures

Metak²,

2006

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“…CRP levels normally rise within 2 to 6 hours after surgery and then go down by the third day after surgery. Ellitsgaard et al conducted a study (on 140 elderly patients with hip fractures) that measured CRP and ESR during the week after the operations 7) . The postoperative ESR in uncomplicated cases remained elevated 1 week after surgery, while the CRP peaked at day 2 and normalized by day 7.…”

Section: Resultsmentioning

confidence: 99%

Comparison of Serum CRP and Procalcitonin in Patients after Spine Surgery

Chung

Won

Kwon

et al. 2011

J Korean Neurosurg Soc

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in a single institution. Exclusion criteria were as follows : preceding the spine surgery in the previous 2 weeks, preexisting or postoperative infection, being less than 18 years of age, and being discharged less than 5 days after the spinal surgery. Clinical data relevant to the study included age, sex, body mass index (BMI), BT, site and type of surgery, and surgery duration.All patients received a preoperative antibiotic prophylaxis with a first generation cephalosporin, cefazolin, and also postoperative antibiotics were injected through their fourth postoperative day. All patients were operated under general anesthesia and received daily clinical examinations until discharge. INTRODUCTIONDespite advances in prophylaxis, the incidence of deep infection after instrumented spinal surgery remains between 0.4% and 4.3% 14,16,19) and may be higher in patients undergoing fusion after spinal trauma 26) . Although infection can be a disabling complication of any surgical procedure, spinal infection can be particularly devastating due to the close proximity of the neurological structures. Early detection of an infection may prevent substantial problem later.It is often difficult to diagnose postoperative spinal infection before clinical symptoms become apparent. Magnetic resonance imaging can help to diagnose the soft-tissue change but is expensive to use as a screening tool and may not be available. Although inflammatory markers, such as C-reactive protein (CRP), white blood cell count (WBC), erythrocyte sedimentation rate (ESR) and body temperature (BT), easily are measured, their specificities are not high.In a recent meta-analysis, procalcitonin (PCT) was superior to Objective : Classical markers of infection cannot differentiate reliably between inflammation and infection after neurosurgery. This study investigated the dynamics of serum procalcitonin (PCT) in patients who had elective spine surgeries without complications. Methods : Participants were 103 patients (47 women, 56 men) who underwent elective spinal surgery. Clinical variables relevant to the study included age, sex, medical history, body mass index (BMI), site and type of surgery, and surgery duration. Clinical and laboratory data were body temperature, white blood cell count (WBC), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and PCT, all measured preoperatively and postoperatively on days 1, 3, and 5. Results : PCT concentrations remained at <0.25 ng/mL during the postoperative course except in 2 patients. PCT concentrations did not correlate with age, sex, DM, hypertension, BMI, operation time, operation site, or use of instrumentation. In contrast, CRP concentrations were significantly higher with older age, male, DM, hypertension, longer operation time, cervical operation, and use of instrumentation. Conclusion : PCT may be useful in the diagnosing neurosurgical patients with postoperative fever of unknown origin.

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“…Previous studies have demonstrated that CRP is a sensitive parameter in monitoring orthopedic postop complications (13,14). However, conflicting data exist regarding the value of IL-6 in monitoring orthopedic postop complications (12,15).…”

Section: Discussionmentioning

confidence: 99%

“…Conversely, Giannoudis and colleagues (12) studied orthopedic blunt trauma victims, and concluded that early assessment of CRP and IL-6 was not beneficial in diagnosing sepsis and that their levels following trauma should be assessed with caution. Ellitsgaard and colleagues (13) studied 140 hip-fracture-operated patients and found high serum CRP levels in postop bronchopneumonia and deep wound infections.…”

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confidence: 99%

Cytokines and C-Reactive Protein Production in Hip-Fracture-Operated Elderly Patients

Beloosesky¹,

Hendel²,

Weiss³

et al. 2007

The Journals of Gerontology Series A: Biological Sciences and M

211

149

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Changes in C-reactive protein and erythrocyte sedimentation rate after hip fractures

Cited by 39 publications

References 11 publications

C-reactive protein as a parameter of surgical trauma: CRP response after different types of surgery in 349 hip fractures

C-reactive protein as a parameter of surgical trauma: CRP response after different types of surgery in 349 hip fractures

Comparison of Serum CRP and Procalcitonin in Patients after Spine Surgery

Cytokines and C-Reactive Protein Production in Hip-Fracture-Operated Elderly Patients

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