2008
DOI: 10.1681/asn.2007121286
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Abstract: Several recent prospective studies have reported that obesity is associated with an increased risk for chronic kidney disease (CKD), but it is unknown whether weight gain increases the risk for CKD if one remains within the "normal" category of body mass index (BMI). We prospectively followed a cohort of 8792 healthy men who had no known risk factors for CKD and participated in a comprehensive health evaluation program at a large worksite. During 35,927 person-years of follow-up, 427 new incident cases of CKD … Show more

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Cited by 76 publications
(60 citation statements)
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“…This result might be understood in the same context as previous studies showing that an increase in BMI predicted CKD development [7]. Most of the previous studies used BMI to assess obesity, because it is easy to measure, correlates well with body fat mass [8], and predicts future morbidity and mortality [9].…”
Section: Discussionsupporting
confidence: 57%
“…This result might be understood in the same context as previous studies showing that an increase in BMI predicted CKD development [7]. Most of the previous studies used BMI to assess obesity, because it is easy to measure, correlates well with body fat mass [8], and predicts future morbidity and mortality [9].…”
Section: Discussionsupporting
confidence: 57%
“…Some researchers reported that obesity indicated by elevated body mass index (BMI) which can induce renal injury 13 is an independent culprit in CKD, 14,15 while others observed a U-shaped association between weight change categories and development of CKD. 16 In addition, few studies have focused on the relationship of CKD with different levels of individual factors in MetS. We speculated that some specific populations and different levels of different factors in MetS may idiosyncratically contribute to CKD, which still requires further explorations.…”
Section: Introductionmentioning
confidence: 94%
“…Risk factors for chronic kidney disease are rapidly emerging from epidemiologic studies, including age, 268,269 nephron mass, 7,270 gender, 268,271 levels of calcidiol, 272 sympathetic activity, 273 obesity and diabetes, 274 cardiovascular disease, 275 genetic loci 276 and polymorphisms, 273,277-279 and epigenetic modifications. 19 But how these risk factors modulate fibrogenesis is still uncertain.…”
Section: Genetic Predisposition To Renal Progressionmentioning
confidence: 99%