Changes in blood-brain barrier permeability and ultrastructure, and protein expression in a rat model of cerebral hypoperfusion

Sekaran, Hema; Gan, Chee‐Yuen; Latiff, Aishah A.; Harvey, T. M.; Nazri, Liyana Mohd; Hanapi, Nur Aziah; Azizi, Juzaili; Yusof, Siti R.

doi:10.1016/j.brainresbull.2019.07.010

Cited by 9 publications

(4 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Palestine, there are a quite a large number of CVA patients according to a study done in northern Palestine, which showed that the annual crude incidence rate of stroke was 51.4 per 100,000 persons [2]. Stroke is caused by the interruption of the blood supply to the brain, this cuts off the supply of oxygen and nutrients, causing damage and ischemia to the brain tissues [3, 4]. The most common symptom of stroke is sudden weakness or numbness of the face, arm or leg, most often on one side of the body which is considered a focal neurological deficit [5].…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Dyslipidemia and Hyperglycemia among Stroke Patients: Preliminary Findings

Ali

Abuissa²,

Alawneh

et al. 2019

Stroke Research and Treatment

View full text Add to dashboard Cite

Background/Aim Stroke or cerebrovascular accident is defined as sudden or sub acute onset of focal neurologic deficit, caused by the interruption of blood flow to parts of the brain. In this study, we aimed to investigate the prevalence of dyslipidemia and hyperglycemia among stroke patients in Palestine. Materials and Methods A total of 70 patients with stroke were included in a cross-sectional study between November 2017 and February 2018. Stroke patients were diagnosed based on a CT scan reviewed by a neurologist. Fasting venous blood samples were collected to measure the lipid profile (cholesterol, low-density lipoproteins (LDL), triacylglycerol (TAG), high-density lipoproteins (HDL)), fasting blood glucose (FBG), and glycosylated hemoglobin (HbA1c) levels. An interview-based questionnaire, included background data, past medical history, family history, and other risk factors for stroke, was filled for each patient. Results Based on our results, 28.57% of patients had high LDL, 17.1% had high cholesterol, 15.7% had high TAG and 61.3% had low HDL. About half of the patients (51.4%) had abnormal HbA1c and abnormal FBG (52.8%). The majority (67.1%) of patients were males, whereas, 11% of patients were obese (BMI of more than 30 kg/m2) and 51.4% were smokers. Regarding the family history of diseases, 81% of patients had a family history of hypertension, 50% had a family history of stroke, and 58% had a family history of diabetes mellitus. ConclusionMale gender and smoking were most likely to increase the risk of stroke. Risk factors like low HDL, high LDL, high FBG, high HbA1c, and hypertension contribute substantially to the incidence of stroke. A family history of stroke, hypertension and diabetes were significant risk factors for stroke.

show abstract

Section: Introductionmentioning

confidence: 99%

The Prevalence of Dyslipidemia and Hyperglycemia among Stroke Patients: Preliminary Findings

Ali

Abuissa²,

Alawneh

et al. 2019

Stroke Research and Treatment

View full text Add to dashboard Cite

show abstract

“…Neuroinflammation contributes to secondary brain injury, and it shatters the integrity of endothelial cell junctions to damage BBB ( Hinson et al., 2015 ; Fukuda and Badaut, 2012 , Sekaran et al., 2019 ). The treatment with the combination of PG and TMZ reduced the extravasation of EB dye, indicating a decrease in the destruction of BBB.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effects of combined trimetazidine and progesterone on cerebral reperfusion injury

Dhote

Mandloi

Singour

et al. 2022

Current Research in Pharmacology and Drug Discovery

View full text Add to dashboard Cite

“…CBF reduces white matter lesions were significantly associated with cognitive impairment, and patients with severe white matter changes have poor attention, executive function, and speed control 124 . The causes of white matter changes may be related to dysfunction of the BBB, perivascular edema, and microglial cell activation 125 . The demyelination of the white matter is further aggravated by perivascular edema caused by proteases produced by the microglial cells.…”

Section: Introductionmentioning

confidence: 99%

Pathological changes in neurovascular units: Lessons from cases of vascular dementia

Wang

Yan

et al. 2021

CNS Neurosci Ther

View full text Add to dashboard Cite

Vascular dementia (VD) is the second leading cause of dementia after Alzheimer's disease (AD). The decrease of cerebral blood flow (CBF) to different degrees is one of the main causes of VD. Neurovascular unit (NVU) is a vessel‐centered concept, emphasizing all the cellular components play an integrated role in maintaining the normal physiological functions of the brain. More and more evidence shows that reduced CBF causes a series of changes in NVU, such as impaired neuronal function, abnormal activation of glial cells, and changes in vascular permeability, all of which collectively play a role in the pathogenesis of VD. In this paper, we review NVU changes as CBF decreases, focusing on each cellular component of NVU. We also highlight remote ischemic preconditioning as a promising approach for VD prevention and treatment from the NVU perspective of view.

show abstract

Changes in blood-brain barrier permeability and ultrastructure, and protein expression in a rat model of cerebral hypoperfusion

Cited by 9 publications

References 75 publications

The Prevalence of Dyslipidemia and Hyperglycemia among Stroke Patients: Preliminary Findings

The Prevalence of Dyslipidemia and Hyperglycemia among Stroke Patients: Preliminary Findings

Neuroprotective effects of combined trimetazidine and progesterone on cerebral reperfusion injury

Pathological changes in neurovascular units: Lessons from cases of vascular dementia

Contact Info

Product

Resources

About