How to cite this article: Hassan HA, Gharib NE, Azhari GF. Antioxidant activity and free radical-scavenging of cape gooseberry (Physalis peruviana L.) in diethylnitrosamine-induced hepatocellular carcinoma. Hepatoma Res 2017;3:27-33.Aim: Oxidative damage of cellular components by free radicals and other reactive oxygen molecules is believed to be associated with the development of degenerative diseases. The aim of the present study was to evaluate the antioxidant capacity and free radical scavenging activity of cape gooseberry juice (CGJ) in diethylnitrosamine-(DENA) and CCl 4 (3 mL/kg b.w.)-induced hepatocellular carcinoma (HCC) rats model. Methods: The rats were divided into 4 groups (6 rats each group). Group 1 (control): the rats of this group did not receive any treatments; group 2 (CGJ): rats were daily administered cape gooseberry juice at a dose of 1 mL/kg b.w.; group 3 (HCC): the rats treated with a single intraperitoneal injection of fresh DENA (200 mg/kg body weight) and received a subcutaneous injection of CCl 4 (3 mL/kg/week); group 4: (HCC + CGJ): rats were treated with DENA (200 mg/kg b.w.) and CCl 4 (3 mL/kg b.w. per week) in addition to daily administered cape gooseberry juice at a dose of 1 mL/kg b.w. Results: Treatment
Key words:Oxidative stress, antioxidants, cape gooseberry, diethylnitrosamine ABSTRACT Article history: