Changed Presentation of Hashimoto's Thyroiditis in North-Eastern Sicily and Calabria (Southern Italy) Based on a 31-Year Experience

Benvenga, Salvatore; Trimarchi, Francesco

doi:10.1089/thy.2007.0234

Cited by 92 publications

(105 citation statements)

References 42 publications

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“…This high prevalence was independently confirmed both in an endocrine division setting (29) and thyroid cytology setting (34,35). More recently, this prevalence -though at lower levels -was confirmed in Catania, our neighbouring province (36).…”

Section: Discussionmentioning

confidence: 55%

“…Patients were defined overtly hyperthyroid when serum TSH was below 0.27 mU/L and FT3 and/or FT4 above their corresponding upper normal limits, and subclinically hyperthyroid when only TSH was abnormal (below 0.27 mU/L). As reported previously, autoimmune thyroiditis was considered present if either condition was met: (i) increased serum levels of one or both thyroid autoantibodies regardless of the thyroid function and thyroid ultrasonography (see below); (ii) thyroid ultrasonography pattern of inflammation regardless of thyroid autoantibodies and thyroid function (29).…”

Section: Biochemical Assaysmentioning

confidence: 99%

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Thyroid function, autoimmunity and nodules in hematological malignancies

Mondello

Sindoni

Pitini

et al. 2015

Arch. Endocrinol. Metab.

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Objective: Hematological malignancies encompass a large spectrum of disease entities whose treatment by chemo/radiotherapy could lead to thyroid complications. To the best of our knowledge, no study has simultaneously addressed thyroid function, autoimmunity and nodularity. Therefore, we decided to conduct one. Materials and methods: We evaluated 82 Caucasian patients (36 women and 46 men), who were treated at our Oncology division for hematological malignancies (multiple myeloma, chronic myeloid leukemia, chronic lymphatic leukemia, non-Hodgkin lymphoma and polycythemia vera) and compared them with a control group of 104 patients. Patients who had received or were receiving external head/neck radiotherapy were excluded. All oncological patients and control individuals underwent thyroid ultrasonography and thyroid function and autoimmunity tests. Results: A lower prevalence of enlarged thyroid and nodules were found in patients with respect to controls. The rate of thyroid nodules was the highest in multiple myeloma and polycythemia vera, and the lowest in chronic lymphatic leukemia. Non-Hodgkin lymphoma patients had the smallest thyroid nodules while men with multiple myeloma the biggest ones. No patient had hypothyroidism, while 5.6% of patients had subclinical hyperthyroidism. In contrast, within the control group the rates of hypothyroidism and hyperthyroidism, overt and subclinical, were 3.8%, 20.2%, 0% and 0% respectively. Moreover, the overall rate of thyroid autoantibody positiveness in patients was significantly lower than controls. Conclusion: In our experience, we found a significantly lower prevalence of thyroid abnormalities in hematologic patients who underwent chemotherapy, but not radiotherapy, with respect to controls. Arch Endocrinol Metab. 2015;59(3):236-44

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Section: Discussionmentioning

confidence: 55%

Section: Biochemical Assaysmentioning

confidence: 99%

Thyroid function, autoimmunity and nodules in hematological malignancies

Mondello

Sindoni

Pitini

et al. 2015

Arch. Endocrinol. Metab.

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“…Moreover, various characteristics of HT have changed over the decades. Affected patients had become younger and the incidence of clinically diagnosed HT in males had increased [2].Apart from its substantial impact on thyroid function, HT also influences general health independent from hypo-or hyperthyroidism [4]. It is associated with decreased quality of life levels [5] as well as a wide range of organ-specific and non-organ-specific autoimmune disorders, as well as other diseases, including neuropsychological/ psychiatric deficits, disorders of the gut, fibromyalgia, and reproductive health issues, among many others [4].…”

mentioning

confidence: 99%

“…Over the last three decades, its incidence has increased substantially, regardless whether it was defined by laboratory, clinical and ultrasonographic features [2] or histological characteristics [3]. Moreover, various characteristics of HT have changed over the decades.…”

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confidence: 99%

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Hashimoto’s Thyroiditis – the Need for a Specific Therapy

Ott¹

2012

Thyroid Disorders Ther

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Hashimoto's thyroiditis (HT) is one of the most common autoimmune disorders and is the most prevalent cause of subclinical or overt hypothyroidism in areas with sufficient iodine intake [1]. Over the last three decades, its incidence has increased substantially, regardless whether it was defined by laboratory, clinical and ultrasonographic features [2] or histological characteristics [3]. Moreover, various characteristics of HT have changed over the decades. Affected patients had become younger and the incidence of clinically diagnosed HT in males had increased [2].Apart from its substantial impact on thyroid function, HT also influences general health independent from hypo-or hyperthyroidism [4]. It is associated with decreased quality of life levels [5] as well as a wide range of organ-specific and non-organ-specific autoimmune disorders, as well as other diseases, including neuropsychological/ psychiatric deficits, disorders of the gut, fibromyalgia, and reproductive health issues, among many others [4].Thus, one of the main questions is whether HT patients who suffer from impairment in quality of life and HT-related symptoms can find medical help. Evidence suggests that both levothyroxine replacement and selenium supplementation are associated with reduce in concentrations of thyroid peroxidase antibodies [6,7]. However, no improvements in thyroid function have been observed with these approaches. Thyroidectomy, on the other hand, will only lead to a relief of mechanical symptoms including a feeling of compression, voice problems and tightness in the neck [8,9]. Keeping in mind that the association between HT and other autoimmune diseases likely derives from a polyclonal autoimmune response against organ-specific autoantigens [10], thyroidectomy will not lead to improvements in a majority of associated conditions und, thus, will only have minor impact on overall quality of life [4].Notably in HT patients, low-level laser therapy of the thymus, thyroid, and supraclavicular fossa induces systemic immunomodulation [11]. A recent randomized, placebo-controlled trial on the efficacy of low-level laser therapy in patients with HT-induced hypothyroidism demonstrated that thyroid function was improved and thyroid peroxidase antibody levels were reduced [12]. This effect was also evident at the last follow-up examination nine months after treatment.HT is considered a multifactorial disease. Recently, Effraimidis et al. [13] proposed a model for the natural history of autoimmune thyroid disease suggesting that a particular genetic background allows development of autoantibodies against thyroid peroxidase. Then, environmental exposure plays a significant role whether the patient will become hyper-or hypothyroid; for example, a high iodine intake and refraining from smoking will favor development toward hypothyroidism [13]. Together with possible influences of radiation [14], the sex hormones [15], and fetal microchimerism [16] the development is based on a variety of factors. Thus, it seems unlikely that primary preven...

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Prevalence of Hashimoto Thyroiditis in Adults With Papillary Thyroid Cancer and Its Association With Cancer Recurrence and Outcomes

Huang

Qian

et al. 2021

JAMA Netw Open

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IMPORTANCE Hashimoto thyroiditis (HT) has been suggested to be associated with papillary thyroid cancer (PTC) development. However, its association with PTC progression remains unclear.OBJECTIVE To examine the association between HT and PTC presentation and outcomes. DESIGN, SETTING, AND PARTICIPANTSThis retrospective cohort study included a review of patients aged 18 to 75 years who had pathologically confirmed PTC treated at a single center in China

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Changed Presentation of Hashimoto's Thyroiditis in North-Eastern Sicily and Calabria (Southern Italy) Based on a 31-Year Experience

Abstract: Only environmental changes, as opposed to genetic changes, can account for such alterations in the presentation of HT in our geographical area.

Cited by 92 publications

References 42 publications

Thyroid function, autoimmunity and nodules in hematological malignancies

Thyroid function, autoimmunity and nodules in hematological malignancies

Hashimoto’s Thyroiditis – the Need for a Specific Therapy

Prevalence of Hashimoto Thyroiditis in Adults With Papillary Thyroid Cancer and Its Association With Cancer Recurrence and Outcomes

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