Change in dietary inflammatory index score is associated with control of long-term rheumatoid arthritis disease activity in a Japanese cohort: the TOMORROW study

Matsumoto, Yoshinari; Shivappa, Nitin; Sugioka, Y.; Tada, Masahiro; Okano, Tadashi; Mamoto, K.; Inui, Kentaro; Habu, Daiki; Hébert, James R.; Koike, Tatsuya

doi:10.1186/s13075-021-02478-y

Cited by 14 publications

(17 citation statements)

References 36 publications

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“…The results of this cross-sectional study based on the American population showed that whether adjusted or not adjusted covariates, the association between DII and RA was positive, and the risk of RA increased with the increase of DII. This is the same result as the previously published study [22][23] .…”

Section: Discussionsupporting

confidence: 93%

“…For example, it was reported that DII was positively associated with the risk of colorectal cancer, cancers of the Upper Aerodigestive Tract, gastric cancer, myocardial infarction, obesity, osteoporosis, sarcopenia, and other diseases [16][17][18][19][20][21] . At present, although some studies have shown that there was an association between DII and RA [22][23] , the ethnicity studied was different, and the results of the study are different. Here, we report on the American population enrolled onto a cross-sectional study to further explore the relationship between DII and RA.…”

Section: Introductionmentioning

confidence: 80%

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The Association between Dietary Inflammation Index and Rheumatoid Arthritis in Americans: a cross-sectional study

Xiang

Wang

Qian

et al. 2021

Preprint

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Background Studies have shown that personal diet has a certain impact on the development and treatment of rheumatoid arthritis (RA). However, the effect of overall dietary structure on RA is still an exploratory issue at present. Dietary inflammation index (DII) is an index that evaluates the inflammatory potential of the total nutrients consumed by human body. Therefore, we studied the correlation between DII and RA in Americans to explore whether the pro-inflammatory or anti-inflammatory effects of diet contribute to the risk of RA. Methods We used data from the 2005–2017 NHANES database for analysis, including 1819 individuals with RA and 8602 individuals without RA. Among them, DII was calculated by collecting the relevant data of Total Nutrient Intakes, First Day in the database. The analysis was carried out through the comparison between the two groups, including logical regression, multiple regression analysis, smooth curve fitting, recursive algorithm, and independent sample T-test. Results After adjusting for other confounding factors, we found that there was a positive correlation between DII and RA in Americans (β = 1.068, 95% CI = 1.026 to 1.111, P = 0.00121). In the subgroup analysis, it was found that characteristics of the participants were younger than 50 years old, female, Other Hispanic, BMI≥25 or federal poverty rate > 185%, there was still a positive association between DII and RA. Compared with non-smokers, the effect between DII and RA of smokers was greater than that of non-smokers. In Other Hispanic, there was an inflection point (K = 1.195). When K > 1.195, the curve gradient increases rapidly. In addition, the intake of energy, protein, dietary fiber, total saturated fatty acids, vitamin E, vitamin B6, magnesium, zinc, Niacin, Selenium, iron, and alcohol in individuals with RA was significantly lower than that in those without RA. Conclusions The inflammatory potential of diet may increase the risk of onset and development of RA. The risk may be different in different individuals, but it may be a feasible way to prevent and alleviate RA by improving dietary structure, reducing pro-inflammatory food, and increasing anti-inflammatory food intake.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 80%

The Association between Dietary Inflammation Index and Rheumatoid Arthritis in Americans: a cross-sectional study

Xiang

Wang

Qian

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…To our knowledge, there was limited study conducted on the association of DII score and activity of rheumatoid arthritis disease. Similar to our nding, in a crosssectional and longitudinal study conducted in Japan showed that anti-in ammatory change in DII score was related with low disease activity (24). According to the ndings of a case-control study, adherence to an in ammatory diet such as Western Diet increases the chances of developing RA, while following a healthy diet can reduce the incidence of the disease (25).…”

Section: Discussionsupporting

confidence: 83%

Associations Between Dietary Inflammatory Index Scores And The Increased Disease Activity of Rheumatoid Arthritis: A Cross-Sectional Study

Nayebi

Soleimani

Mostafaei

et al. 2021

Preprint

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Background: Diet plays an important role in regulating inflammation, which is a hallmark of rheumatoid arthritis (RA). Our aim was to investigate the association between the inflammatory potential of diet and RA activity.Methods: This cross-sectional study was conducted on 184 patients with RA in rheumatology clinic in Kermanshah city, Iran, in 2020. RA was diagnosed according to the criteria of the 2010 American College of Rheumatology/ European League against Rheumatism. The overall inflammatory potential of the diet was extracted from a validated 168-item food frequency questioner (FFQ) using the Dietary Inflammatory Index (DII). RA disease activity was assessed using Disease Activity Score 28 (DAS28) scores. Logistic regression and one-way ANOVA/ ANCOVA were conducted. Results: Individuals in the highest DII quartile had the significantly higher odds of positive C-reactive protein (CRP) than those in the lowest quartile of the DII scores (OR: 4.5; 95% CI: 1.16 – 17.41; P-value: 0.029). A statistically significant downward linear trend in fat-free mass and weight were observed with increasing the DII quartiles (P-value=0.003, P-value=0.019, respectively). Patients in the highest DII quartile had higher DAS 28 scores than those in the first quartile (Mean difference: 1.16; 95% CI: 0.51 – 1.81; P-value <0.001) and second quartile of the DII scores (Mean difference: 1.0; 95% CI: 0.34 – 1.65; P-value <0.001).Conclusion: Our results indicated that reducing inflammation through diet might be one of the therapeutic strategies to control and reduce the disease activity in RA patients.

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“…High expression of iNOS and COX2 could further induce the production of catabolic factors, including ADAMTS5, MMP1, MMP3, and MMP13, which may lead to damage of the articular cartilage ( Lepetsos et al, 2019 ). Strategies for reducing the level of inflammation have proven to be effective in treating OA ( Matsumoto et al, 2021 ; Zeng et al, 2021 ). In this study, PA significantly reduced the generation of iNOS and COX2 in chondrocytes pretreated with IL-1β.…”

Section: Discussionmentioning

confidence: 99%

Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect

Liang

et al. 2021

Front. Pharmacol.

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Osteoarthritis (OA) is a common articular ailment presented with cartilage loss and destruction that is common observed in the elderly population. Physalin A (PA), a natural bioactive withanolide, exerts anti-inflammatory residences in more than a few diseases; however, little is known about its efficacy for OA treatment. Here, we explored the therapeutic effects and potential mechanism of PA in mouse OA. After the in vitro administration of PA, the expression of inflammation indicators including inducible nitric oxide synthase and cyclooxygenase-2 was low, indicating that PA could alleviate the IL-1β-induced chondrocyte inflammation response. Moreover, PA reduced IL-1β-induced destruction of the extracellular matrix by upregulating the gene expression of anabolism factors, including collagen II, aggrecan, and sry-box transcription factor 9, and downregulating the gene expression of catabolic factors, including thrombospondin motif 5 and matrix metalloproteinases. In addition, the chondroprotective effect of PA was credited to the inhibition of mitogen-activated protein kinase (MAPK) and nuclear factor-κB (NF-κB) signaling pathways. Furthermore, in vivo experiments showed that intra-articular injection of PA could alleviate cartilage destruction in a mouse OA model. However, the anti-inflammatory, anabolism enhancing, catabolism inhibiting, and MAPK and NF-κB signaling pathway inhibiting properties of PA on IL-1β-induced chondrocytes could be reversed when integrin αVβ3 is knocked down by siRNA. In conclusion, our work demonstrates that PA exhibits a chondroprotective effect that may be mediated by integrin αVβ3. Thus, PA or integrin αVβ3 might be a promising agent or molecular target for the treatment of OA.

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Change in dietary inflammatory index score is associated with control of long-term rheumatoid arthritis disease activity in a Japanese cohort: the TOMORROW study

Cited by 14 publications

References 36 publications

The Association between Dietary Inflammation Index and Rheumatoid Arthritis in Americans: a cross-sectional study

The Association between Dietary Inflammation Index and Rheumatoid Arthritis in Americans: a cross-sectional study

Associations Between Dietary Inflammatory Index Scores And The Increased Disease Activity of Rheumatoid Arthritis: A Cross-Sectional Study

Physalin A Inhibits MAPK and NF-κB Signal Transduction Through Integrin αVβ3 and Exerts Chondroprotective Effect

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