Challenges to cervical cancer treatment in Bangladesh: The development of a women's cancer ward at Dhaka Medical College Hospital

Haque, Niloufar; Uddin, Aaliya; Dey, Bimalangshu R.; Islam, Ferdousi; Goodman, Annekathryn

doi:10.1016/j.gore.2017.06.001

Cited by 16 publications

(20 citation statements)

References 36 publications

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“…and lack of knowledge of cervical cancer risk factors. 15,[18][19][20] Other risk Infection with HPV spreads from one individual to another through sex, including vaginal, anal, and oral sex. In a recent study, the prevalence of HPV in both urban and rural women in Bangladesh was reported to be 7.7%.…”

Section: Risk Factors Associated With Cervical Cancer In Bangladeshmentioning

confidence: 99%

“…Chemoradiotherapy is the standard treatment for women with Stage IB2 to IVA disease; however, Bangladesh has a severe shortage of resources for radiation therapy. 19,38 For an individual with cervical cancer, the average waiting time for radiotherapy is 6 months. To reduce this long wait, Bangladesh has opted to provide neoadjuvant chemotherapy (NACT), 19 NACT before surgery.…”

Section: Current Treatments For Cervical Cancer In Bangladeshmentioning

confidence: 99%

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Cervical cancer in low‐income countries: A Bangladeshi perspective

Hoque

Haque

Karim

2020

Intl J Gynecology & Obste

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Cervical cancer is the fourth most common cancer among women worldwide, with approximately 70% of cases involving infection with human papillomavirus (HPV) genotypes 16 and 18. According to International Agency for Research on Cancer, more than 50 million Bangladeshi women are at risk of developing cervical cancer, and 17 686 new cases and 10 362 deaths occur annually. If diagnosed at the precursor stage, however, cervical cancer is a condition that can be successfully treated. As a result, screening programs are necessary to identify the disease before it progresses to invasive cancer. In the present review, we discuss the overall situation of cervical cancer in Bangladesh, summarizing the sociodemographic status of affected women, associated risk factors, screening approaches, and treatment options. We emphasize the potential of visual inspection with acetic acid (VIA) as a cost‐effective screening approach for detecting cervical lesions among poor women in the community. In a resource‐limited country such as Bangladesh, VIA may represent an ideal model to build an effective awareness campaign through urban and rural hospitals, community‐based clinics, and other health facilities available in industry.

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Section: Risk Factors Associated With Cervical Cancer In Bangladeshmentioning

confidence: 99%

Section: Current Treatments For Cervical Cancer In Bangladeshmentioning

confidence: 99%

Cervical cancer in low‐income countries: A Bangladeshi perspective

Hoque

Haque

Karim

2020

Intl J Gynecology & Obste

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“…Nevertheless, invasive examinations may cause adverse psychological effects, including anxiety, depression or distress (37). Surgery, chemotherapy and radiotherapy (38) are the three major therapeutic strategies in the treatment of CC; however, their uses may be limited for various reasons. Surgery may be limited by the status and stage of patients, including late stage or tolerance to anesthesia (39), whereas chemotherapy is limited due to the lack of sensitivity and the development of drug resistance (40).…”

Section: Introductionmentioning

confidence: 99%

Comprehensive gene and pathway analysis of cervical cancer progression

Fang

et al. 2020

Oncol Lett

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Cervical Cancer is one of the leading causes of cancer-associated mortality in women. The present study aimed to identify key genes and pathways involved in cervical cancer (CC) progression, via a comprehensive bioinformatics analysis. The GSE63514 dataset from the Gene Expression Omnibus database was analyzed for hub genes and cancer progression was divided into four phases (phases I-IV). Pathway enrichment, protein-protein interaction (PPI) and pathway crosstalk analyses were performed, to identify key genes and pathways using a criterion nodal degree ≥5. Gene pathway analysis was determined by mapping the key genes into the key pathways. Co-expression between key genes and their effect on overall survival (OS) time was assessed using The Cancer Genome Atlas database. A total of 3,446 differentially expressed genes with 107 hub genes were identified within the four phases. A total of 14 key genes with 11 key pathways were obtained, following extraction of ≥5 degree nodes from the PPI and pathway crosstalk networks. Gene pathway analysis revealed that CDK1 and CCNB1 regulated the cell cycle and were activated in phase I. Notably, the following terms, 'pathways in cancer', 'focal adhesion' and the 'PI3K-Akt signaling pathway' ranked the highest in phases II-IV. Furthermore, FN1, ITGB1 and MMP9 may be associated with metastasis of tumor cells. STAT1 was indicated to predominantly function at the phase IV via cancer-associated signaling pathways, including 'pathways in cancer' and 'Toll-like receptor signaling pathway'. Survival analysis revealed that high ITGB1 and FN1 expression levels resulted in significantly worse OS. CDK1 and CCNB1 were revealed to regulate proliferation and differentiation through the cell cycle and viral tumorigenesis, while FN1 and ITGB1, which may be developed as novel prognostic factors, were co-expressed to induce metastasis via cancer-associated signaling pathways, including PI3K-Art signaling pathway, and focal adhesion in CC; however, the underlying molecular mechanisms require further research.

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“…Compared with treatment barriers described in some LMIC ( Kivuti-Bitok et al, 2013 ; Makau-Barasa et al, 2017 ; Haque et al, 2017 ), NCI Paraguay had several strengths. The facility leadership and physicians were aware of the shortcomings of the treatment process and committed to improving it.…”

Section: Discussionmentioning

confidence: 99%

Improving quality of care and timely access to radiation therapy for patients with invasive cervical cancer at the National Cancer Institute Paraguay

Jacobson

Chuang

Pankow

2018

Gynecologic Oncology Reports

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The purpose of this report is to describe the interventions implemented between 2012 and 2017 at the National Cancer Institute Paraguay (NCI Paraguay) to improve treatment quality and efficiency for patients with cervical cancer, with an emphasis on radiation quality and access. The NCI Paraguay requested collaboration with Health Volunteers Overseas (HVO), an international volunteer organization, to improve the care of patients with cervical cancer. This report is based on site visits to NCI Paraguay by HVO volunteers in 2012, 2013, and 2016, with a follow-up report from the site in 2017. During the study period, increased access to external beam radiation and brachytherapy led to a decrease in wait time to start radiation from 2 to 3 months to 4–6 weeks. The center transitioned from 2-dimensional (2D) to 3-D planning and was able to offer concurrent chemotherapy and radiation, including brachytherapy, to patients with locally advanced cervical cancer. Based on the American Society of Clinical Oncology's resource-stratified clinical guidelines, from 2012 to 2017, the practice transitioned from a “basic setting” to an “enhanced setting”.

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Challenges to cervical cancer treatment in Bangladesh: The development of a women's cancer ward at Dhaka Medical College Hospital

Cited by 16 publications

References 36 publications

Cervical cancer in low‐income countries: A Bangladeshi perspective

Cervical cancer in low‐income countries: A Bangladeshi perspective

Comprehensive gene and pathway analysis of cervical cancer progression

Improving quality of care and timely access to radiation therapy for patients with invasive cervical cancer at the National Cancer Institute Paraguay

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