Challenges in the Screening and Management of Osteoporosis

LaVallee, Lisa A.; Scott, Mollie Ashe; Hulkower, Stephen

doi:10.18043/ncm.77.6.416

Cited by 7 publications

(2 citation statements)

References 15 publications

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“…Postmenopausal osteoporosis is a progressive deteriorative condition characterized by low bone mass and microarchitectural deterioration of the skeleton, leading to enhanced bone fragility and a consequent increased risk of fracture. 1 It has been estimated that more than one-third of postmenopausal women suffer from primary osteoporosis. 2,3 Postmenopausal osteoporosis may cause not only fractures but also chronic pain.…”

Section: Introductionmentioning

confidence: 99%

<p>Oxidative Stress Contributes to Hyperalgesia in Osteoporotic Mice</p>

Tu¹,

Wu²,

Huang³

et al. 2020

JPR

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Purpose: Chronic pain is one of the most common complications of postmenopausal osteoporosis. Since oxidative stress is involved in the pathogenesis of postmenopausal osteoporosis, we explored whether oxidative stress contributes to postmenopausal osteoporotic pain. Methods: Osteoporosis was induced in mice by ovariectomy (OVX). Pain-related behaviours were assessed by measuring sensitivity to mechanical, thermal and cold stimulation. The expression of pain-related transcripts, such acid-sensing ion channel 3 (ASIC3), transient receptor potential vanilloid 1 (TRPV1) and calcitonin gene-related peptide (CGRP), was evaluated. Plasma markers of oxidative stress were also measured. In addition, the effects of the reactive oxygen species scavenger phenyl N-tert-butylnitrone (PBN) on these parameters were assessed. Results: The OVX mice presented hyperalgesia, as demonstrated by decreased paw withdrawal thresholds to mechanical stimulation and withdrawal latencies to thermal and cold stimulation, along with upregulated expression of ASIC3, TRPV1 and CGRP in the dorsal root ganglia, spinal cord and thalamus tissue. OVX elevated the plasma levels of malondialdehyde (MDA) and advanced oxidation protein products (AOPPs). However, the administration of PBN alleviated these effects. Conclusion: Our results indicated that oxidative stress contributes to hyperalgesia in OVX mice. Enhanced oxidative stress may be associated with osteoporotic pain. Antioxidant treatment could help alleviate chronic pain in postmenopausal osteoporotic patients.

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Section: Introductionmentioning

confidence: 99%

<p>Oxidative Stress Contributes to Hyperalgesia in Osteoporotic Mice</p>

Tu¹,

Wu²,

Huang³

et al. 2020

JPR

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“…Another health concern that is often associated with age is osteoporosis. Lisa A. LaVallee and colleagues [27] discuss this silent disease in their article in this issue. The authors share information related to the cost, prevalence, and burden of this disease, as well as recommendations for screening, treatment, and care management.…”

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confidence: 99%

Creating a Better State of Health for Women

Pettiford

2016

North Carolina Medical Journal

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Women's wellness spans from childhood into adolescence, through the childbearing period, and into older age. It includes not only wellness issues related to cardiovascular disease, cancer, and other chronic conditions but also the consequences of intimate partner violence and mental health issues.Throughout the life course, women's health should be a priority. Healthier women lead to healthier babies, which lead to healthier communities. In addition, when women are connected to the health care system, their families are also more likely to be connected. This issue of the North Carolina Medical Journal explores the many aspects of women's health and its many impacts. Improving the health of women is an important issue that requires our collective attention. Not only is every woman impacted by her own health status, but her health also influences her entire family. This issue of the North Carolina Medical Journal focuses on the health status of women throughout the lifespan.Healthier women tend to have healthier birth outcomes. Supporting women during the preconception period in order to help them address chronic health issues, behavioral health issues, and social and economic challenges helps to move women toward a more positive life trajectory. Social determinants of health [1]-the structural conditions in which people are born, grow, live, work, and age-also play a critical role. A focus on social determinants of health is needed in order to address our ongoing challenges with health equity.North Carolina has long been striving to improve women's perinatal health. In March 2016, the state released a collaborative 12-point Perinatal Health Strategic Plan that focused on infant mortality, maternal health, maternal mortality, and the health status of men and women of childbearing age. In this issue of the NCMJ, Sarah Verbiest and I outline the key components of this plan and provide details on these 12 points [2]. This plan focuses on improving health care for women and men, strengthening families and communities, and addressing social and economic inequities. Adapting the framework shared by Michael Lu and colleagues [3], the plan infuses social determinants of health and health equity throughout. As data confirm, we must address the 2-fold disparity in birth outcomes in order to see overall improvements. Also in this issue, a sidebar by Brett Prestia and colleagues [4] offers a historical perspective on infant mortality in our state since the late 1980s, including programs and services that were developed during that time. This article references Executive Order 99 [5], which established the 5-year Governor's Commission on the Reduction of Infant Mortality. This sidebar also provides information on more recent efforts, one of which is the development of a statewide Preconception Health Strategic Plan [6] in 2008 and the supplement to this plan developed in 2014 [7]. Both documents focus on strategies for women to improve behaviors and chronic health conditions. The plan's priorities include pregnancy intendednes...

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