Challenges and opportunities in elucidating the structures of biofilm exopolysaccharides: A case study of the Pseudomonas aeruginosa exopolysaccharide called Pel
Kristen Amyx‐Sherer,
Courtney Reichhardt
Abstract:Biofilm formation protects bacteria from antibiotic treatment and host immune responses, making biofilm infections difficult to treat. Within biofilms, bacterial cells are entangled in a self‐produced extracellular matrix that typically includes exopolysaccharides. Molecular‐level descriptions of biofilm matrix components, especially exopolysaccharides, have been challenging to attain due to their complex nature and lack of solubility and crystallinity. Solid‐state nuclear magnetic resonance (NMR) has emerged … Show more
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