Challenges and Opportunities in Drug Delivery for Wound Healing

Whittam, Alexander J.; Maan, Zeshaan N.; Duscher, Dominik; Wong, Victor W.; Barrera, Janos A.; Januszyk, Michael; Gurtner, Geoffrey C.

doi:10.1089/wound.2014.0600

Cited by 115 publications

(75 citation statements)

References 48 publications

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“…[ 64 ] These wounds are often incurable, remaining open for more than 12 weeks, leading to increased rates in disability, amputation, and mortality. [ 65 ] Various GFs play important roles in regulating the wound healing process. [ 66 ] Therefore, exogenous GF therapy is one approach in regulating the wound healing process.…”

Section: Stimuli‐responsive Growth Factor Delivery Systems In Tissue mentioning

confidence: 99%

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Jiang

Zhou

et al. 2020

Adv Healthcare Materials

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Growth factors (GFs) play a crucial role in directing stem cell behavior and transmitting information between different cell populations for tissue regeneration. However, their utility as therapeutics is limited by their short half‐life within the physiological microenvironment and significant side effects caused by off‐target effects or improper dosage. “Smart” materials that can not only sustain therapeutic delivery over a treatment period but also facilitate on‐demand release upon activation are attracting significant interest in the field of GF delivery for tissue engineering. Three properties are essential in engineering these “smart” materials: 1) the cargo vehicle protects the encapsulated therapeutic; 2) release is targeted to the site of injury; 3) cargo release can be modulated by disease‐specific stimuli. The aim of this review is to summarize the current research on stimuli‐responsive materials as intelligent vehicles for controlled GF delivery; Five main subfields of tissue engineering are discussed: skin, bone and cartilage, muscle, blood vessel, and nerve. Challenges in achieving such “smart” materials and perspectives on future applications of stimuli‐responsive GF delivery for tissue regeneration are also discussed.

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Section: Stimuli‐responsive Growth Factor Delivery Systems In Tissue mentioning

confidence: 99%

Stimuli‐Responsive Delivery of Growth Factors for Tissue Engineering

Jiang

Zhou

et al. 2020

Adv Healthcare Materials

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“…118,119 Nanoparticle-based technology was implemented to protect the targeted delivery of siRNA from potential degradation of this effector molecule by intracellular RNases. 120 A (MMP)-2 siRNA-incorporated linear polyethylenimine (LPEI) complex was immobilized onto a nanofibrous mesh via MMP cleavable peptides allowing for controlled release. 121 This system efficiently suppressed MMP-2 levels and promoted wound healing in diabetic murine wounds.…”

Section: Gene Rna Interference (Rnai) and Small Interfering Rna (Simentioning

confidence: 99%

“…Achieving targeted delivery of therapeutics is significant to improve efficacy, reduce any harmful side effects on the nontarget tissues, and reduce cost of therapy. 120 A few known examples of targeted wound-healing therapeutics are discussed below.…”

Section: Nanotechnology-based Targeted Delivery To Achieve Cell-type mentioning

confidence: 99%

Nanotechnology-Driven Therapeutic Interventions in Wound Healing: Potential Uses and Applications

et al. 2017

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The chronic nature and associated complications of nonhealing wounds have led to the emergence of nanotechnology-based therapies that aim at facilitating the healing process and ultimately repairing the injured tissue. A number of engineered nanotechnologies have been proposed demonstrating unique properties and multiple functions that address specific problems associated with wound repair mechanisms. In this outlook, we highlight the most recently developed nanotechnology-based therapeutic agents and assess the viability and efficacy of each treatment, with emphasis on chronic cutaneous wounds. Herein we explore the unmet needs and future directions of current technologies, while discussing promising strategies that can advance the wound-healing field.

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“…Dear Editor , There remains a significant need for therapeutic interventions for wound healing, as the clinical and socioeconomic challenges presented by the ageing population and associated rise in nonhealing wounds persist, exerting enormous pressure on health services . MicroRNAs (miRNAs) are short ~22‐nucleotide noncoding RNA molecules that fine‐tune gene expression by degradation of mRNA targets .…”

mentioning

confidence: 99%

“…DOI: 10.1111/bjd.17576 DEAR EDITOR, There remains a significant need for therapeutic interventions for wound healing, as the clinical and socioeconomic challenges presented by the ageing population and associated rise in nonhealing wounds persist, exerting enormous pressure on health services. 1 MicroRNAs (miRNAs) are short~22-nucleotide noncoding RNA molecules that finetune gene expression by degradation of mRNA targets. 2 Several miRNAs promote keratinocyte migration, including miR-21, miR-31 and miR-132, 3 hence miRNA-dependent migration is emerging as a framework for wound healing.…”

mentioning

confidence: 99%