Chagas disease in Mexico: an analysis of geographical distribution during the past 76 years - A review

Cruz-Reyes, Alejandro; Pickering-López, José Miguel

doi:10.1590/s0074-02762006000400001

Cited by 128 publications

(110 citation statements)

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“…The disease was seen as an exotic ailment and did not receive adequate government attention. The prevalence of Chagas disease in the country ranges from 1.6% to 5.8%, with positivity rates of 0.4% to 19% in different states, 0.17% to 17% in blood banks [4][5][6] . and from 5% to 21.5% in rural areas 6 .…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of Trypanosoma cruzi Mexican strains and their behavior in the mouse experimental model

Gómez-Hernández

Rezende-Oliveira

Nascentes

et al. 2011

Rev. Soc. Bras. Med. Trop.

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Introduction: For a long time, the importance of Chagas disease in Mexico, where many regarded it as an exotic malady, was questioned. Considering the great genetic diversity among isolates of Trypanosoma cruzi, the importance of this biological characterization, and the paucity of information on the clinical and biological aspects of Chagas disease in Mexico, this study aimed to identify the molecular and biological characterization of Trypanosoma cruzi isolates from different endemic areas of this country, especially of the State of Jalisco. Methods: Eight Mexican Trypanosoma cruzi strains were biologically and genetically characterized (PCR specific for Trypanosoma cruzi, multiplex-PCR, amplification of space no transcript of the genes of the mini-exon, amplification of polymorphic regions of the mini-exon, classification by amplification of intergenic regions of the spliced leader genes, RAPD -(random amplified polymorphic DNA). Results: Two profiles of parasitaemia were observed, patent (peak parasitaemia of 4.6×10 6 to 10 7 parasites/mL) and subpatent. In addition, all isolates were able to infect 100% of the animals. The isolates mainly displayed tropism for striated (cardiac and skeletal) muscle. PCR amplification of the mini-exon gene classified the eight strains as TcI. The RAPD technique revealed intraspecies variation among isolates, distinguishing strains isolated from humans and triatomines and according to geographic origin. Conclusions: The Mexican T. cruzi strains are myotrophic and belong to group TcI. Keywords: Trypanosoma cruzi. Mexico. Biological characterization. Genetic characterization. RESUMOIntrodução: Durante muito tempo, foi questionada a importância da doença de Chagas no México onde muitos a consideravam um padecimento exótico. Considerando a grande diversidade genética existente, entre os isolados de Trypanosoma cruzi, a importância da caracterização biológica desses e o escasso número de informações sobre os aspectos clínicos e biológicos da doença de Chagas no México, o objetivo deste trabalho foi realizar a caracterização biológica e molecular de isolados de Trypanosoma cruzi originários de diferentes áreas endêmicas deste país, principalmente do Estado de Jalisco. Métodos: Oito cepas mexicanas de Trypanosoma cruzi foram caracterizadas biologicamente e geneticamente (PCR específica para Trypanosoma cruzi, PCR-multiplex, amplificação do espaço não transcrito dos genes do mini-exon, amplificação das regiões polimórficas do gene do mini-exon, classificação pela amplificação de regiões intergênicas dos genes do spliced leader, RAPD -random amplified polymorphic DNA). Resultados: Foram observados dois tipos de parasitemia: patente com picos máximos de parasitemia entre 4,6x10 6 e 10 7 parasitas/mL e subpatente. Além disso, todos os isolados foram capazes de infectar 100% dos animais. Observou-se tropismo predominante pelo músculo estriado (cardíaco e esquelético). As técnicas de PCR do gene do mini-éxon classificaram as oito cepas como TcI e a técnica de RAPD mostrou variaçã...

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Section: Introductionmentioning

confidence: 99%

Molecular characterization of Trypanosoma cruzi Mexican strains and their behavior in the mouse experimental model

Gómez-Hernández

Rezende-Oliveira

Nascentes

et al. 2011

Rev. Soc. Bras. Med. Trop.

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“…Existen, al menos, 30 especies descritas de triatominos en el país, de las cuales, nueve son consideradas como importantes por su contribución al mantenimiento de la enfermedad en humanos y animales (2). La zona occidental del país se considera zona endémica, lo que se ha demostrado por el número de casos presuntivos de enfermedad, detectados serológicamente o mediante las manifestaciones clínicas y por los reportes de los bancos de sangre (3)(4)(5).…”

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“…En diversas áreas de los cuatro estados de la zona occidental se han encontrado siete de las nueve especies de triatominos consideradas como los vectores más importantes de la enfermedad de Chagas en México (2). Entre ellas, Meccus longipennis [(Usinger), 1939] se destaca por su distribución, grado de domiciliación y positividad a T. cruzi (6)(7)(8)(9)(10), por lo que se considera la especie vector principal de T. cruzi en el estado de Jalisco (5,7).…”

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Vigilancia de la presencia de triatominos mediante gallineros en el sur de Jalisco, México

et al. 2010

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Introducción. En México, la enfermedad de Chagas es un problema de salud pública. Se han registrado, al menos, 30 especies de triatominos vectores, la mayoría con hábitos domésticos y tendencia a invadir las viviendas humanas. Objetivo. Evaluar la utilidad de gallineros en la vigilancia de la presencia de triatominos peridomésticos y conocer su situación en el área de estudio. Materiales y métodos. Se realizó un estudio de campo, experimental, longitudinal, por un año. Se instalaron 50 gallineros en 50 viviendas de tres localidades del municipio de Teocuitatlán de Corona, en el estado de Jalisco, México. Se inspeccionaron los gallineros y las viviendas para saber si aquéllos podían detectar la presencia de triatominos, para estimar la situación vectorial en el área. Resultados. Se recolectaron significativamente (p<0,05) más especímenes de Meccus longipennis (93%) que de Triatoma barberi (7%). Aproximadamente, un tercio (31,3%) de los especímenes de M. longipennis y ninguno de T. barberi se recolectó en los gallineros. M. longipennis tuvo un porcentaje de infección por Trypanosoma cruzi de 25,7%, y T. barberi, de 53,2%. Los meses de primavera y verano fueron en los que se recolectaron más ejemplares de triatominos. Conclusiones. Los gallineros se consideran una herramienta útil para detectar la presencia de ejemplares de M. longipennis, aunque no funcionaron para T. barberi. Se confirma la importancia de M. longipennis y se establece el posible rol primario de T. barberi como vector en el área de estudio.Palabras clave: enfermedad de Chagas, Triatominae, vectores de enfermedades, vigilancia, aves de corral, México.Monitoring triatomid bug (Hemiptera: Reduviidae) presence by sentinel chicken coops in Southern Jalisco State, México Introduction. Chagas disease is an important public health problem in Mexico. At least 30 Triatominae species, vectors of that disease have been recorded, most with domiciliary habits and tendency to invade human dwellings. Objective. The usefulness of using chicken coops was evaluated for monitoring peridomestic triatomine presence, identity and infection with Trypanosoma cruzi. Materials and methods. A year-long, longitudinal field study was designed. Fifty chicken coops were placed in 50 human dwellings on three localities in Teocuitatlán de Corona County, Jalisco State, Mexico. The coops and human dwellings were routinely inspected to determine if the coops alone can monitor for the presence of triatomines. Results. Significantly (p<0.05) more Meccus longipennis specimens (93.0%) than of Triatoma barberi (7.0%) were collected. Almost a third (31.3%) of M. longipennis and none of T. barberi specimens were collected in the coops. Meccus longipennis was found with infections of Trypanosoma cruzi of 25.7%, and T. barberi of 53.2%. Most triatomines were collected in spring and summer months. Conclusions. Chicken coops proved useful tools to detect presence of M. longipennis; however, they were not effective for T. barberi. The importance of M. longipennis as a potential vector was confir...

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“…Nine of them are considered important vectors of Trypanosoma cruzi to human populations (Cruz-Reyes & Pickering-López 2006). Amongst these can be included the five more distributed species of the Phyllosoma complex, Meccus phyllosomus (Burmeister), Meccus longipennis (Usinger), Meccus pallidipennis (Stål), Meccus picturatus (Usinger) and Meccus mazzottii (Usinger).…”

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Occurrence of hybrids and laboratory evidence of fertility among three species of the Phyllosoma complex (Hemiptera: Reduviidae) in Mexico

Martínez-Ibarra

Salazar-Schettino

Nogueda‐Torres

et al. 2009

Mem. Inst. Oswaldo Cruz

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Chagas disease in Mexico: an analysis of geographical distribution during the past 76 years - A review

Cited by 128 publications

References 25 publications

Molecular characterization of Trypanosoma cruzi Mexican strains and their behavior in the mouse experimental model

Molecular characterization of Trypanosoma cruzi Mexican strains and their behavior in the mouse experimental model

Vigilancia de la presencia de triatominos mediante gallineros en el sur de Jalisco, México

Occurrence of hybrids and laboratory evidence of fertility among three species of the Phyllosoma complex (Hemiptera: Reduviidae) in Mexico

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