Chagas disease: a new worldwide challenge

Coura, José Rodrigues; Viñas, Pedro Albajar

doi:10.1038/nature09221

Cited by 492 publications

(428 citation statements)

References 8 publications

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“…Therefore, there is an urgent need to develop new, safe and effective therapeutic alternatives that are also cost-effective. [10][11][12][13] Multiple anti-infective activities are well known for quinoxaline derivatives. [14,15] Our group has vast experience in the synthesis and biological evaluation of multiple quinoxaline 1,4-di-Noxide derivatives, having identified a broad spectrum of anti-infective activities.…”

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confidence: 99%

Novel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agents

Torres

Moreno‐Viguri

Galiano

et al. 2013

European Journal of Medicinal Chemistry

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ABSTRACT. As a continuation of our research and with the aim of obtaining new agents against Chagas disease, an extremely neglected disease which threatens 100 million people, eighteen new quinoxaline 1,4-di-N-oxide derivatives have been synthesized following the Beirut reaction. The synthesis of the new derivatives was optimized through the use of a new and more efficient microwave-assisted organic synthetic method. The new derivatives showed excellent in vitro biological activity against Trypanosoma cruzi. Compound 17, which was substituted with 2 fluoro groups at the 6-and 7-positions of the quinoxaline ring, was the most active and selective in the cytotoxicity assay. The electrochemical study showed that the most active compounds, which were substituted by electron-withdrawing groups, possessed a greater ease of reduction of the N-oxide groups.

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mentioning

confidence: 99%

Novel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agents

Torres

Moreno‐Viguri

Galiano

et al. 2013

European Journal of Medicinal Chemistry

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“…However, all parasites exist in an environment in which they will, in addition to their hosts, encounter very many other species, creating significant potential for non-host species to be important in the dispersal of the parasite [9,10]. There are many classic cases of organisms vectoring parasites by acting as an intermediate host in which the parasite completes part of its life cycle [11,12]. However, the incidental dispersal of parasites on the body surface of a vector, or following passage through the gut without infection taking place, may also be of great importance, particularly for parasites that transmit faecal-orally or via contact.…”

Section: Introductionmentioning

confidence: 99%

Parasites in bloom: flowers aid dispersal and transmission of pollinator parasites within and between bee species

2015

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The dispersal of parasites is critical for epidemiology, and the interspecific vectoring of parasites when species share resources may play an underappreciated role in parasite dispersal. One of the best examples of such a situation is the shared use of flowers by pollinators, but the importance of flowers and interspecific vectoring in the dispersal of pollinator parasites is poorly understood and frequently overlooked. Here, we use an experimental approach to show that during even short foraging periods of 3 h, three bumblebee parasites and two honeybee parasites were dispersed effectively onto flowers by their hosts, and then vectored readily between flowers by non-host pollinator species. The results suggest that flowers are likely to be hotspots for the transmission of pollinator parasites and that considering potential vector, as well as host, species will be of general importance for understanding the distribution and transmission of parasites in the environment and between pollinators.

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“…Aunque es endémica en el continente americano (20,21), su distribución mundial ha cambiado significativamente debido a los movimientos migratorios (22).…”

Section: Discussionunclassified

Anti-Trypanosoma cruzi antibodies in Latin American migrants in transit through the México- USA border

2018

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Introducción. En los últimos años, la tripanosomiasis americana se ha convertido en un problema de salud pública emergente en países receptores de poblaciones migrantes, como México, Estados Unidos, Canadá y los países europeos.Objetivo. Analizar la prevalencia de anticuerpos anti-Trypanosoma cruzi mediante técnicas serológicas, en los migrantes latinos en su paso hacia Estados Unidos y Canadá.Materiales y métodos. Se hicieron análisis serológicos mediante ELISA y la prueba de hemaglutinación indirecta (HAI) para detectar anticuerpos anti-T. cruzi, y encuestas socioeconómicas para determinar los factores asociados a los casos seropositivos que favorecieron la transmisión en el país de origen de los migrantes.Resultados. La seroprevalencia total en la población estudiada fue del 20 % (24/120). La prevalencia más alta se encontró en migrantes de Guatemala, con 37,5 % (6/16), seguidos de los de Honduras (22,6 %; 12/53), El Salvador (16 %; 4/25) y México (8,7 %; 3/23). De los 120 migrantes encuestados, 105 (87,5 %) reconocieron el vector y 62 (59 %) afirmaron haber sido picados por este. La asociación de la infección con los materiales de construcción de las paredes de las viviendas, así como con la presencia de mascotas (perros) en los hogares, fue muy significativa (p≤0,01). La asociación con el material de construcción del patio, los servicios básicos precarios, así como la cría de animales dentro de corrales en la periferia de los hogares, también fue significativa (p≤0,05).Conclusión. Los países no endémicos que reciben migrantes de zonas endémicas deben mejorar o desarrollar políticas de salud para prevenir la transmisión del parásito por transfusión o por vía congénita.

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Chagas disease: a new worldwide challenge

Cited by 492 publications

References 8 publications

Novel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agents

Novel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agents

Parasites in bloom: flowers aid dispersal and transmission of pollinator parasites within and between bee species

Anti-Trypanosoma cruzi antibodies in Latin American migrants in transit through the México- USA border

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