This study examined the effects of the position and number of the supply openings (SOs) and exhaust openings (EOs) on the inhaled-air quality of inpatients using Computational Fluid Dynamics (CFD) analysis. The positions and number of SOs and EOs were selected to create mixing ventilation, displacement ventilation for a calm indoor environment, and personal ventilation for each inpatient's ventilation. The effect of the installation of a curtain in the sickroom on the inhaled-air quality for inpatients was also examined. The inhaled-air quality of the inpatients was evaluated using the age of air, residual life of air, contribution ratio of nostril-exhaled air, and contribution ratio of the pollution source from the sickroom floor. CFD analysis showed that displacement ventilation, which uses a large SO with a low airflow velocity, supplied better air to the inpatients than the other ventilation methods, but pollution from the sickroom floor made a significant contribution. Overall, in general sickrooms and intensive care units, low-airflow-velocity displacement ventilation can supply high-quality air to the inpatients but the sickroom floor must be cleaned thoroughly.