2021
DOI: 10.3390/cancers13246182
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Abstract: High-risk human papillomavirus (HR HPV) causes nearly all cervical cancers, half of which are due to HPV type 16 (HPV16). HPV16 oncoprotein E6 (16E6) binds to NFX1-123, and dysregulates gene expression, but their clinical implications are unknown. Additionally, HPV16 E7’s role has not been studied in concert with NFX1-123 and 16E6. HR HPVs express both oncogenes, and transformation requires their expression, so we sought to investigate the effect of E7 on gene expression. This study’s goal was to define gene e… Show more

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Cited by 5 publications
(5 citation statements)
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References 30 publications
(63 reference statements)
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“…Inhibition of CPT1A significantly inhibits tumor growth, improves survival, and increases the sensitivity of nasopharyngeal carcinoma to radiotherapy ( 125 ). Almost all CCs are associated with high-risk HPV infections, and HPV16 is responsible for nearly 50% of infections ( 12 , 13 ). The level of CPT1A in HPV16-positive CC tissues was reported to be markedly higher than that in normal tissues, suggesting that CPT1A could promote cervical cancer progression through lipid metabolism modifications ( 51 ).…”
Section: Targeting Fatty Acid Oxidationmentioning
confidence: 99%
See 1 more Smart Citation
“…Inhibition of CPT1A significantly inhibits tumor growth, improves survival, and increases the sensitivity of nasopharyngeal carcinoma to radiotherapy ( 125 ). Almost all CCs are associated with high-risk HPV infections, and HPV16 is responsible for nearly 50% of infections ( 12 , 13 ). The level of CPT1A in HPV16-positive CC tissues was reported to be markedly higher than that in normal tissues, suggesting that CPT1A could promote cervical cancer progression through lipid metabolism modifications ( 51 ).…”
Section: Targeting Fatty Acid Oxidationmentioning
confidence: 99%
“…Of note, nearly a quarter of CC patients do not have elevated SCC Ag levels ( 11 ). Furthermore, almost all CCs are related to high-risk human papillomavirus (HPV) infections, of which nearly 50% are HPV16 infections ( 12 , 13 ). However, HPV infection is not a requirement.…”
Section: Introductionmentioning
confidence: 99%
“…The rate‐determining factor for telomerase is the expression of its catalytic subunit, hTERT 140 . HR‐HPVE6 relies on multiple cellular proteins, including NFX1‐123, which is upregulated in HPV16‐positive cervical cancer to regulate the activity of hTERT and telomerase 141,142 . HPV16 E6 binds to the promoter region of hTERT, inducing its expression and ultimatly activating the function of telomerase 143 .…”
Section: Hpv and Its Pathogenesismentioning
confidence: 99%
“…140 HR-HPVE6 relies on multiple cellular proteins, including NFX1-123, which is upregulated in HPV16-positive cervical cancer to regulate the activity of hTERT and telomerase. 141,142 HPV16 E6 binds to the promoter region of hTERT, inducing its expression and ultimatly activating the function of telomerase. 143 Recently, researchers have found that HPVE6 interaction with AuyB, enhances hTERT expression and augments telomerase activity.…”
Section: Host Target Proteins Involved In Cell Proliferationmentioning
confidence: 99%
“…Not only did 16E6 bind NFX1 gene products, but we have determined that NFX1-123 expression is increased in cervical dysplasia samples and is highly expressed in cervical cancers and cervical cancer cell lines [ 31 ]. Additionally, in The Cancer Genome Atlas cervical cancer data set, 13.2% of genes correlated with NFX1 expression; among those correlative genes, there was significant enrichment for those associated with protein binding and RNA binding [ 32 ]. These data emphasize the value of understanding how 16E6 may increase the expression and co-opt the typical function of NFX1-123 and, based on the protein motifs found in NFX1-123, how 16E6 may utilize this host protein to drive oncogenesis in keratinocytes.…”
Section: 16e6 Interaction With Nfx1-123mentioning
confidence: 99%