Cervical Cancer: A Global Health Crisis

Small, William; Bacon, Monica; Bajaj, Amishi; Chuang, Linus; Fisher, Brandon J.; Harkenrider, Matthew M.; Jhingran, Anuja; Kitchener, Henry C; Mileshkin, Linda; Viswanathan, Akila N.; Gaffney, David K.

doi:10.1097/01.ogx.0000526010.06041.5e

Cited by 117 publications

(156 citation statements)

References 52 publications

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“…In summary, PET/MRI is a more efficacious approach to the diagnosis of cervical cancer relative to other available imaging modalities. Primary lesions that are 4 cm in diameter are the diagnostic basis for locally advanced cervical cancer, 36 in addition to serving as the reference basis for cavity radiation therapy. Primary lesions ranging from 2 to 4 cm in size are optimal candidates for preoperative neoadjuvant chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Relative clinical utility of simultaneous ¹⁸F-fluorodeoxyglucose PET/MRI and PET/CT for preoperative cervical cancer diagnosis

et al. 2021

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Objective To investigate the utility of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/magnetic resonance imaging (PET/MRI) for the preoperative diagnosis of cervical cancer. Methods We retrospectively analyzed 114 patients who were diagnosed with cervical cancer and underwent PET/MRI (n = 59) or PET/computed tomography (PET/CT) (n = 65) before surgery. The maximal standardized uptake value (SUVmax) and mean SUV (SUVmean) were determined for regions of interest in the resultant radiographic images. Results Relative to PET/CT, 18F-FDG PET/MRI exhibited higher specificity and sensitivity in defining the primary tumor bounds and higher sensitivity for detection of bladder involvement. The SUVmax and SUVmean of PET/MRI were remarkably higher than those of PET/CT as a means of detecting primary tumors, bladder involvement, and the lymph node status. However, no significant differences in these values were detected when comparing the two imaging approaches as a means of detecting vaginal involvement or para-aortic lymph node metastasis. Conclusions These outcomes may demonstrate the capability of 18F-FDG PET/MRI to clarify preoperative cervical cancer diagnoses in the context of unclear PET/CT findings. However, studies directly comparing SUVs in different lesion types from patients who have undergone both PET/MRI and PET/CT scans are essential to validate and expand upon these findings.

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Section: Discussionmentioning

confidence: 99%

Relative clinical utility of simultaneous ¹⁸F-fluorodeoxyglucose PET/MRI and PET/CT for preoperative cervical cancer diagnosis

et al. 2021

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“…Sebaliknya, tumor yang timbul dari endoserviks lebih mungkin menjadi adenokarsinoma. 8 Pada penelitian yang dilakukan oleh Claritha DC et al 9 yang mendiskusikan penelitian dari Nelli tahun 2017 dan juga penelitian dari Ningsih tahun 2017, disimpulkan bahwa wanita, terutama yang bersenggama usia dini di bawah 20 tahun, di mana pada usia pubertas SCJ menjadi terekspos menyebabkan epitel torak terlihat pada ektoserviks dan akhirnya mengalami metaplasia skuamosa (perubahan satu tipe sel dewasa menjadi tipe sel dewasa lain, dalam hal ini epitel berlapis gepeng menjadi selapis torak) membentuk daerah yang disebut zona transformasi dan mengakibatkan seseorang lebih rentan terinfeksi Human Papilloma Virus (HPV) yang dapat berkembang menjadi kanker serviks. 9,32,33 Tipe HPV dibagi atas risiko tinggi dan risiko rendah.…”

Section: Bahasan Onkogenesisunclassified

Onkogenesis, Morfologi, dan Modalitas Deteksi Dini Karsinoma Serviks

Rapar

Sambuaga

Durry

2021

MSJ

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The incidence and mortality rates of cervical cancer in developing countries are relatively high compared to developed countries. The main risk factor for cervical cancer is high risk human papilloma virus (HPV) infection, such as types 16 and 18. Types of high-risk HPV expresses oncoproteins E6 and E7 which play an essential role in the pathogenesis of cervical carcinoma through inhibition of the activity of gene group expression products that play a role in suppressing tumor growth, such as p53 and pRB. This process will cause morphological changes in the squamous epithelium from precancerous lesions to cancer. The development of squamous epithelial cell cancer can be prevented through screening tests in order to detect cervical cancer early. This study was aimed to obtain the oncogenesis, morphology, and early detection modality of cervical carcinoma. This was a literature review study using three databases, as follows: ClinicalKey, PubMed, and Google Scholar. The results explained that p53 and pRB suppression by high-risk HPV oncoproteins E6 and E7 played an important role in the pathogenesis of cervical carcinoma. The most common histological type is squamous cell carcinoma. Screening tests such as visual inspection with acetic acid (VIA), Pap smears and HPV DNA have an important role as modalities for early detection of malignancy. More specifically VIA and Pap smears are suitable for Indonesia which is a developing country, especially when implemented in peripheral areas.Keywords: oncogenesis; morphological changes; early detection; cervical carcinoma Abstrak: Insidens dan mortalitas kanker serviks di negara berkembang relatif tinggi dibandingkan negara maju. Faktor risiko utama dari kanker serviks adalah infeksi human papilloma virus (HPV) risiko tinggi yaitu tipe 16 dan 18. HPV tipe risiko tinggi mengekspresikan onkoprotein E6 dan E7, yang berperan penting dalam patogenesis karsinoma serviks melalui inhibisi terhadap aktivitas produk-produk ekspresi kelompok gen yang berperan dalam menekan pertumbuhan tumor, seperti p53 dan pRB. Proses ini akan menyebabkan perubahan morfologik pada epitel skuamosa mulai dari lesi prakanker sampai kanker. Perkembangan kanker sel epitel skuamosa dapat dicegah melalui pemeriksaan skrining guna mendeteksi dini kanker serviks. Penelitian ini bertujuan untuk mengetahui onkogenesis, morfologi, dan modalitas deteksi dini karsinoma serviks. Jenis penelitian ialah literature review menggunakan tiga basis data yaitu ClinicalKey, PubMed, dan Google Scholar. Hasil penelitian mendapatkan bahwa penekanan p53 dan pRB oleh onkoprotein HPV risiko tinggi E6 dan E7 sangat berperan penting dalam patogenesis karsinoma serviks. Tipe histologik tersering ialah tipe karsinoma sel skuamosa. Pemeriksaan skrining seperti pemeriksaan inspeksi visual dengan asam asetat (IVA), Pap smear dan HPV DNA memiliki peran penting sebagai modalitas deteksi dini keganasan. Lebih khusus IVA dan Pap smear cocok untuk negara Indonesia yang merupakan negara berkembang, terutama bila diimplementasikan di daerah perifer.Kata kunci: onkogenesis; perubahan morfologik; deteksi dini; karsinoma serviks

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“…The endo-cervix is composed of glandular cells whereas the ecto-cervix is made up of squamous cells. Transformation zone is the place where these regions adjoin, and where most of the cervical cancer is known to originate [6]. Starting with the transformation zone the cells in the squamous region are typically classified as basal, para-basal, intermediate and superficial respectively.…”

Section: Introductionmentioning

confidence: 99%

Cytopathology Using High Resolution Digital Holographic Microscopy

Ahlawat¹,

Sharma²,

Pandey³

et al. 2022

Augmented Reality and Its Application

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We summarize a study involving simultaneous imaging of cervical cells from Pap-smear samples using bright-field and quantitative phase microscopy. The optimization approach to phase reconstruction used in our study enables full diffraction limited performance from single-shot holograms and is thus suitable for reducing cost of a quantitative phase microscope system. Over 48000 cervical cells from patient samples obtained from three clinical sites have been imaged in this study. The clinical sites used different sample preparation methodologies and the subjects represented a range of age groups and geographical diversity. Visual examination of quantitative phase images of cervical cell nuclei show distinct morphological features that we believe have not appeared in the prior literature. A PCA based analysis of numerical parameters derived from the bright-field and quantitative phase images of the cervical cells shows good separation of superficial, intermediate and abnormal cells. The distribution of phase based parameters of normal cells is also shown to be highly overlapping among different patients from the same clinical site, patients across different clinical sites and for two age groups (below and above 30 years), thus suggesting robustness and possibility of standardization of quantitative phase as an imaging modality for cell classification in future clinical usage.

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Cervical Cancer: A Global Health Crisis

Abstract: This is the author manuscript accepted for publication and has undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version record. Please cite this article as

Cited by 117 publications

References 52 publications

Relative clinical utility of simultaneous ¹⁸F-fluorodeoxyglucose PET/MRI and PET/CT for preoperative cervical cancer diagnosis

Relative clinical utility of simultaneous ¹⁸F-fluorodeoxyglucose PET/MRI and PET/CT for preoperative cervical cancer diagnosis

Onkogenesis, Morfologi, dan Modalitas Deteksi Dini Karsinoma Serviks

Cytopathology Using High Resolution Digital Holographic Microscopy

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Cervical Cancer: A Global Health Crisis

Abstract: This is the author manuscript accepted for publication and has undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version record. Please cite this article as

Cited by 117 publications

References 52 publications

Relative clinical utility of simultaneous 18F-fluorodeoxyglucose PET/MRI and PET/CT for preoperative cervical cancer diagnosis

Relative clinical utility of simultaneous 18F-fluorodeoxyglucose PET/MRI and PET/CT for preoperative cervical cancer diagnosis

Onkogenesis, Morfologi, dan Modalitas Deteksi Dini Karsinoma Serviks

Cytopathology Using High Resolution Digital Holographic Microscopy

Contact Info

Product

Resources

About

Relative clinical utility of simultaneous ¹⁸F-fluorodeoxyglucose PET/MRI and PET/CT for preoperative cervical cancer diagnosis

Relative clinical utility of simultaneous ¹⁸F-fluorodeoxyglucose PET/MRI and PET/CT for preoperative cervical cancer diagnosis