1973
DOI: 10.1136/jnnp.36.5.724
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Abstract: SUMMARYThe effect of intracarotid injection of serotonin (5-HT) on internal carotid artery flow and oxygen availability (02a) of the cerebral cortex was studied in 10 baboons. Vasoconstriction occurred in the vascular bed of the territory supplied by the injected artery. After one middle cerebral artery was occluded the vasoconstrictor effect of 5-HT was more pronounced, particularly in the non-ischaemic hemisphere. The capacity of the cerebral vessels to provide collateral blood flow was reduced in both ischa… Show more

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Cited by 43 publications
(8 citation statements)
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References 39 publications
(45 reference statements)
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“…-In conformity with the fact that this substance does not cross the BBB, it has been found that intracarotid application of serotonin produces equivocal effects upon intracranial blood flow (32,33,34), although it constricts the scalp arteries (32) and reduces the calibre of the internal carotid artery (35,36); -As reviewed by Rosenblum (37), serotonin has, likewise, failed to consistently produce marked degrees of constriction when locally applied to the pial microcirculation;…”
Section: Factors Involved In the Genesis Of Brain Hypoxiamentioning
confidence: 92%
“…-In conformity with the fact that this substance does not cross the BBB, it has been found that intracarotid application of serotonin produces equivocal effects upon intracranial blood flow (32,33,34), although it constricts the scalp arteries (32) and reduces the calibre of the internal carotid artery (35,36); -As reviewed by Rosenblum (37), serotonin has, likewise, failed to consistently produce marked degrees of constriction when locally applied to the pial microcirculation;…”
Section: Factors Involved In the Genesis Of Brain Hypoxiamentioning
confidence: 92%
“…Progres sive ischemia in the border zone of an infarct re sulting in the gradual increase in infarct size has previously been reported (Welch et al, 1973). Pos sible mechanisms to account for progression of stroke include edema formation (O'Brien et al, 1974), release of serotonin or thromboxane A2 from aggregating platelets (Welch et al, 1973;Hallen beck and Furlow, 1979), and increased extracellular potassium (Wade et al, 1975). Our laboratory has demonstrated blood -brain barrier alterations within the infarcting tissue as early as 30 min fol lowing irradiation .…”
Section: Fig 2 At 4 H Following Irradiation Asymmetrical Patterns mentioning
confidence: 96%
“…Unilateral common carotid ligation in this animal consistently induces cerebral hemispheric ischemia in 40 to 50% of animals, 4 the incidence of ischemia and eventual infarction apparently depending on vascular anatomical variation. 6 Since the incidence of eventual infarction in the gerbil seems so dependent on adequacy of collateral circulation, it seemed appropriate to use this model to test the hypothesis that neuronal release of 5-HT with subsequent vasoconstriction may limit collateral vasocapacitance in foci of cerebral ischemia, thereby contributing to the progression of ischemia. 6 Therefore, a separate animal group was pretreated with the tryptophan-hydroxylase inhibitor, pchlorophenylalanine (PCPA), in order to deplete cerebral tissue 5-HT content and determine if the stroke incidence rate was thus modified.…”
mentioning
confidence: 99%