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“…Two well-described and extensively-investigated cerebral hemodynamic indices in both human and animal models are cerebrovascular reactivity to CO 2 , or acetazolamide, [1619] and cerebral autoregulation, or pressure regulation [2023] Both mechanisms compensate for changing metabolic demands and arterial pressure on account of various physiological and pathological conditions. [17;2022;24]. Several noninvasive techniques can be used to assess autoregulation and CO 2 vasoreactivity, as well as vascular and functional responses to other stimuli, such as TCD, near infrared spectroscopy (NIRS), 3D- arterial spin labeling (3D CASL) MRI, blood-oxygen-level dependent (BOLD) MRI, 2D time of flight MR angiography, single-photon emission computed tomography (SPECT), and positron emission tomography (PET).…”
Section: Brain Vascular Reservementioning
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“…Two well-described and extensively-investigated cerebral hemodynamic indices in both human and animal models are cerebrovascular reactivity to CO 2 , or acetazolamide, [1619] and cerebral autoregulation, or pressure regulation [2023] Both mechanisms compensate for changing metabolic demands and arterial pressure on account of various physiological and pathological conditions. [17;2022;24]. Several noninvasive techniques can be used to assess autoregulation and CO 2 vasoreactivity, as well as vascular and functional responses to other stimuli, such as TCD, near infrared spectroscopy (NIRS), 3D- arterial spin labeling (3D CASL) MRI, blood-oxygen-level dependent (BOLD) MRI, 2D time of flight MR angiography, single-photon emission computed tomography (SPECT), and positron emission tomography (PET).…”
Section: Brain Vascular Reservementioning
“…Whilst some reviews dealing with TCD studies of CA in syncope concluded that CA was not impaired in these patients [38,127,150] others suggested that CA could contribute to syncope [43,81]. However, a broader review of the literature shows a more complex pattern.…”
Section: Ca In Syncope and Ans Conditionsmentioning
“…Dynamic cerebrovascular autoregulation has been studied following transient changes in BP induced by rapid deflation of large cuffs previously placed around the upper thighs [17], following transient carotid artery compression [18], performance of the Valsalva maneuver [19,20] or following spontaneous or mechanically induced changes in BP [21][22][23]. In our experience, repeated thigh cuff deflation is often uncomfortable to patients and requires a minimum of three measurements in any one condition in order to be considered valid [24].…”
Section: Dynamic Cerebrovascular Autoregulation Prior To Syncopementioning