Cerebrospinal-Fluid Transaminase Concentrations in Clinical Cerebral Infarctions

Green, Joseph B.; O'Doherty, Desmond S.; Oldewurtel, Henry A.; Forster, Francis M.

doi:10.1056/nejm195701312560506

Cited by 30 publications

(3 citation statements)

References 6 publications

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“…Since the report of Wakim and Fleisher [33] about an ele vated CSF ASAT activity after an experimental cerebral infarction in dog, several investigations have appeared confirming this observation also in man [13,19]. However, a marked elevation is found only in large infarcts within a few days after the onset of attack [5].…”

Section: Discussionmentioning

confidence: 92%

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Cerebrospinal Fluid Concentration of Cyclic AMP in Cerebrovascular Diseases

Heikkinen¹,

Myllylä²,

Hokkanen³

et al. 1976

Eur Neurol

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Concentration of cyclic adenosine 3’,5’-monophosphate (cAMP) and activities of some enzymes were measured in cerebrospinal fluid (CSF) from 38 patients with various cerebrovascular diseases. Cerebral infarction of the carotid area <14 days after the attack) revealed a significant increase in CSF cAMP level in comparison to a transient ischemic attack (TIA) and cephalalgia without any pathological findings (control group). A trend towards elevated values was observed also in cerebral hemorrhage, whereas the CSF cAMP concentrations in subarachnoid hemorrhage, TIA, syncope, and cerebral infarction of at least 2 months of duration were in the range of control values. A significant rise in CSF enzyme activities was observed only in hemorrhagic disorders. Hypertensive patients with TIA showed significantly higher CSF cAMP values than normotensive ones. A similar positive correlation between blood pressure and CSF cAMP concentrations was found also in subarachnoid hemorrhage and syncope groups. On the basis of the present results it is suggested that in cerebrovascular diseases CSF cAMP concentration reflects the size and the time of the destruction of cerebral cells, and correlates with hypertension of the patient possibly indicating an increased sympathetic activity.

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Section: Discussionmentioning

confidence: 92%

“…The measurement of some CSF enzyme activities has been utilized for several years to support the diagnosis of various central nervous system (CNS) diseases [13,17,23]. The alterations of CSF enzyme activities have been correlated earlier with cAMP concentrations in our previous studies [15,25].…”

Section: Introductionmentioning

confidence: 99%

Cerebrospinal Fluid Concentration of Cyclic AMP in Cerebrovascular Diseases

Heikkinen¹,

Myllylä²,

Hokkanen³

et al. 1976

Eur Neurol

View full text Add to dashboard Cite

show abstract

“…The increased intracranial pressure is presumably a result of cerebellar or medullary softening with subsequent compression and dislocation of the aqueduct and the fourth ventricle (42). Unfortunately, the initial hope that elevation of the level of the enzyme, glutamic oxalacetic transaminase, in the cerebrospinal fluid would aid in differentiating cerebral infarctions from cerebral tumors and other neurologic disorders has not been fulfilled (43).…”

Section: Discussionmentioning

confidence: 99%