Cerebrospinal Fluid Transaminase and Lactic Dehydrogenase Activities in Neurologic Disease

Lactate dehydrogenase and aspartete transaminase of the cerebrospinal fluid in patients with brain tumours, congenital hydrocephalus, and brain abscess.

“…However, the present study revealed raised values of CSF LD and AST in 90 percent of similar patients; those having normal CSF enzymes had mostly supratentorial tuberculomas and in one case a brain stem glioma. These results are in partial agreement with those of Green et al (1958) and Mellick and Bassett (1964), because their observed frequencies of raised enzymatic activities were lower than the present ones. The CSF LD and AST activities in both supratentorial and infratentorial tumours are significantly higher than those in the control group (Table 2), and the difference between the two groups of tumours is not significant (Table 3).…”

“…Thus, in general, the estimations of CSF LD are slightly superior to those of CSF AST, both in incidence of abnormality and in degree of its rise. The lactate dehydrogenase activity of the tumour cyst fluid is regarded as a better index of the degree of malignancy than its activity in the CSF (Green et al, 1958;Szliwowski and Cumings, 1961;Buckell and Robertson, 1965;Buckell et al, 1970). This is supported by the present observations whereby dehydrogenase estimations in the cyst fluid of three benign tumours (colloid cyst of third ventricle, craniopharyngioma, and the epidermoid) were uniformly lower than those in the malignant tumours.…”

“…The normal CSF LD (Jakoby and Jakoby, 1958) and CSF AST (Green et al, 1957;Mann et al, 1960) in various types of brain tumours were also noted subsequently. However, Green et al (1958Green et al ( , 1959) recorded a rise of both enzymes in the CSF in benign as well as malignant tumours. Still others emphasised the increased activity of one (Wroblewski et al, 1958;Mellick and Bassett, 1964) or both (Davies-Jones, 1969) enzymes in the malignant tumours alone, which were either primary or secondary in origin.…”

Lactate dehydrogenase and aspartete transaminase of the cerebrospinal fluid in patients with brain tumours, congenital hydrocephalus, and brain abscess.

“…However, the present study revealed raised values of CSF LD and AST in 90 percent of similar patients; those having normal CSF enzymes had mostly supratentorial tuberculomas and in one case a brain stem glioma. These results are in partial agreement with those of Green et al (1958) and Mellick and Bassett (1964), because their observed frequencies of raised enzymatic activities were lower than the present ones. The CSF LD and AST activities in both supratentorial and infratentorial tumours are significantly higher than those in the control group (Table 2), and the difference between the two groups of tumours is not significant (Table 3).…”

“…Thus, in general, the estimations of CSF LD are slightly superior to those of CSF AST, both in incidence of abnormality and in degree of its rise. The lactate dehydrogenase activity of the tumour cyst fluid is regarded as a better index of the degree of malignancy than its activity in the CSF (Green et al, 1958;Szliwowski and Cumings, 1961;Buckell and Robertson, 1965;Buckell et al, 1970). This is supported by the present observations whereby dehydrogenase estimations in the cyst fluid of three benign tumours (colloid cyst of third ventricle, craniopharyngioma, and the epidermoid) were uniformly lower than those in the malignant tumours.…”

“…The normal CSF LD (Jakoby and Jakoby, 1958) and CSF AST (Green et al, 1957;Mann et al, 1960) in various types of brain tumours were also noted subsequently. However, Green et al (1958Green et al ( , 1959) recorded a rise of both enzymes in the CSF in benign as well as malignant tumours. Still others emphasised the increased activity of one (Wroblewski et al, 1958;Mellick and Bassett, 1964) or both (Davies-Jones, 1969) enzymes in the malignant tumours alone, which were either primary or secondary in origin.…”

Lactate Dehydrogenase in Cerebral Cyst Fluids

“…The fluid that accumulates in a cystic tumor has so far received less attention than the tumor tissue. High LDH activity in a specimen of cyst fluid from a cerebral astrocytoma was reported by Green,et al,7 in an account of LDH and transaminase activities of the cerebrospinal fluid (CSF) of patients with various neurological diseases. Szliwowski and Cumings 1~ determined LDH activity in some of the 214 cerebral cyst fluids that they examined chemically and found a tendency for the higher levels to be associated with more malignant tumors.…”

Evaluation of the Landscape of Pharmacodynamic Biomarkers in GM1 and GM2 Gangliosidosis

“…In GM1 and GM2, neuronal death is responsible for the progressive deterioration of CNS function. Analysis of cerebrospinal fluid (CSF) in other neurological conditions (e.g., Alzheimer disease) demonstrates aspartate aminotransferase (AST) elevations during CNS damage, which may indicate a potential nonspecific biomarker for neurological damage [50][51][52]. Cell damage leads to AST release in the extracellular space, potentially serving as a direct measure of CNS damage [53].…”

Lactate dehydrogenase and aspartete transaminase of the cerebrospinal fluid in patients with brain tumours, congenital hydrocephalus, and brain abscess.

“…However, the present study revealed raised values of CSF LD and AST in 90 percent of similar patients; those having normal CSF enzymes had mostly supratentorial tuberculomas and in one case a brain stem glioma. These results are in partial agreement with those of Green et al (1958) and Mellick and Bassett (1964), because their observed frequencies of raised enzymatic activities were lower than the present ones. The CSF LD and AST activities in both supratentorial and infratentorial tumours are significantly higher than those in the control group (Table 2), and the difference between the two groups of tumours is not significant (Table 3).…”

“…Thus, in general, the estimations of CSF LD are slightly superior to those of CSF AST, both in incidence of abnormality and in degree of its rise. The lactate dehydrogenase activity of the tumour cyst fluid is regarded as a better index of the degree of malignancy than its activity in the CSF (Green et al, 1958;Szliwowski and Cumings, 1961;Buckell and Robertson, 1965;Buckell et al, 1970). This is supported by the present observations whereby dehydrogenase estimations in the cyst fluid of three benign tumours (colloid cyst of third ventricle, craniopharyngioma, and the epidermoid) were uniformly lower than those in the malignant tumours.…”

“…The normal CSF LD (Jakoby and Jakoby, 1958) and CSF AST (Green et al, 1957;Mann et al, 1960) in various types of brain tumours were also noted subsequently. However, Green et al (1958Green et al ( , 1959) recorded a rise of both enzymes in the CSF in benign as well as malignant tumours. Still others emphasised the increased activity of one (Wroblewski et al, 1958;Mellick and Bassett, 1964) or both (Davies-Jones, 1969) enzymes in the malignant tumours alone, which were either primary or secondary in origin.…”

Lactate Dehydrogenase in Cerebral Cyst Fluids

“…The fluid that accumulates in a cystic tumor has so far received less attention than the tumor tissue. High LDH activity in a specimen of cyst fluid from a cerebral astrocytoma was reported by Green,et al,7 in an account of LDH and transaminase activities of the cerebrospinal fluid (CSF) of patients with various neurological diseases. Szliwowski and Cumings 1~ determined LDH activity in some of the 214 cerebral cyst fluids that they examined chemically and found a tendency for the higher levels to be associated with more malignant tumors.…”

Evaluation of the Landscape of Pharmacodynamic Biomarkers in GM1 and GM2 Gangliosidosis

“…In GM1 and GM2, neuronal death is responsible for the progressive deterioration of CNS function. Analysis of cerebrospinal fluid (CSF) in other neurological conditions (e.g., Alzheimer disease) demonstrates aspartate aminotransferase (AST) elevations during CNS damage, which may indicate a potential nonspecific biomarker for neurological damage [50][51][52]. Cell damage leads to AST release in the extracellular space, potentially serving as a direct measure of CNS damage [53].…”

Lactate dehydrogenase and aspartete transaminase of the cerebrospinal fluid in patients with brain tumours, congenital hydrocephalus, and brain abscess.

“…However, the present study revealed raised values of CSF LD and AST in 90 percent of similar patients; those having normal CSF enzymes had mostly supratentorial tuberculomas and in one case a brain stem glioma. These results are in partial agreement with those of Green et al (1958) and Mellick and Bassett (1964), because their observed frequencies of raised enzymatic activities were lower than the present ones. The CSF LD and AST activities in both supratentorial and infratentorial tumours are significantly higher than those in the control group (Table 2), and the difference between the two groups of tumours is not significant (Table 3).…”

“…Thus, in general, the estimations of CSF LD are slightly superior to those of CSF AST, both in incidence of abnormality and in degree of its rise. The lactate dehydrogenase activity of the tumour cyst fluid is regarded as a better index of the degree of malignancy than its activity in the CSF (Green et al, 1958;Szliwowski and Cumings, 1961;Buckell and Robertson, 1965;Buckell et al, 1970). This is supported by the present observations whereby dehydrogenase estimations in the cyst fluid of three benign tumours (colloid cyst of third ventricle, craniopharyngioma, and the epidermoid) were uniformly lower than those in the malignant tumours.…”

“…The normal CSF LD (Jakoby and Jakoby, 1958) and CSF AST (Green et al, 1957;Mann et al, 1960) in various types of brain tumours were also noted subsequently. However, Green et al (1958Green et al ( , 1959) recorded a rise of both enzymes in the CSF in benign as well as malignant tumours. Still others emphasised the increased activity of one (Wroblewski et al, 1958;Mellick and Bassett, 1964) or both (Davies-Jones, 1969) enzymes in the malignant tumours alone, which were either primary or secondary in origin.…”

Lactate Dehydrogenase in Cerebral Cyst Fluids

“…The fluid that accumulates in a cystic tumor has so far received less attention than the tumor tissue. High LDH activity in a specimen of cyst fluid from a cerebral astrocytoma was reported by Green,et al,7 in an account of LDH and transaminase activities of the cerebrospinal fluid (CSF) of patients with various neurological diseases. Szliwowski and Cumings 1~ determined LDH activity in some of the 214 cerebral cyst fluids that they examined chemically and found a tendency for the higher levels to be associated with more malignant tumors.…”

Evaluation of the Landscape of Pharmacodynamic Biomarkers in GM1 and GM2 Gangliosidosis

“…In GM1 and GM2, neuronal death is responsible for the progressive deterioration of CNS function. Analysis of cerebrospinal fluid (CSF) in other neurological conditions (e.g., Alzheimer disease) demonstrates aspartate aminotransferase (AST) elevations during CNS damage, which may indicate a potential nonspecific biomarker for neurological damage [50][51][52]. Cell damage leads to AST release in the extracellular space, potentially serving as a direct measure of CNS damage [53].…”