Cerebrospinal fluid pressure correlated with body mass index

Ren, Ruojin; Wang, Ke; Zhang, Xiaojun; Tian, Guohong; Jonas, Jost B.

doi:10.1007/s00417-011-1746-1

Cited by 73 publications

(80 citation statements)

References 11 publications

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“…Performing a multivariate analysis in the training group with the lumbar CSFP measurements as dependent variable and age, body mass index and blood pressure as independent variables revealed, that CSFP was best described by the formula of CSFP 21.91. The association between higher CSFP and younger age, higher body mass index and higher blood pressure had also been found in other previous investigations [11,12]. We then tested the formula in the testing group.…”

Section: Ethics Statementsupporting

confidence: 70%

Diabetic retinopathy and estimated cerebrospinal fluid pressure. The Beijing eye study 2011

JONAS¹,

WANG²,

XU³

et al. 2014

Acta Ophthalmologica

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Purpose: The cerebrospinal fluid pressure (CSFP) is a major determinant of central retinal vein pressure and thus of retinal capillary pressure. We tested the hypothesis whether prevalence and severity of diabetic retinopathy are associated with CSFP. Conclusions: Higher prevalence and severity of diabetic retinopathy were associated with higher estimated CSFP after adjusting for systemic parameters. Higher CSFP through a higher retinal vein pressure may lead to more marked retinal venous congestion and vascular leakage in diabetic retinae. Methods

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Section: Ethics Statementsupporting

confidence: 70%

Diabetic retinopathy and estimated cerebrospinal fluid pressure. The Beijing eye study 2011

JONAS¹,

WANG²,

XU³

et al. 2014

Acta Ophthalmologica

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“…It confirmed previous investigations that had also reported on associations of higher CSFP with younger age, higher body mass index, and higher blood pressure. 7,8,16 Applying the formula in the independent test group revealed that the measured CSFP (12.6 ± 4.8 mm Hg) did not differ significantly (P = 0.29) from the calculated CSFP (13.3 ± 3.2 mm Hg). A Durbin-Watson value of 2.08 indicated a nonsignificant autocorrelation for the residuals in the multiple regression models (Durbin-Watson values in the range of 1.5-2.5 have usually been considered to be acceptable).…”

Section: Methodsmentioning

confidence: 86%

“…In analogy to the association between retinal vein occlusions and arterial hypertension, the association between an increased retinal vein-to-artery diameter ratio and arterial hypertension may also be explained by the direct effect of blood pressure on the CSFP. 7,8,16 In a similar manner, papilledema occurring as hallmark of stage IV of hypertensive retinopathy may not directly be caused by high arterial blood pressure but indirectly by the concomitantly elevated CSFP. Interestingly, other hypertensive retinal microvascular abnormalities such as arteriovenous crossing signs and arteriolar focal narrowing were not related to CSFP.…”

Section: Discussionmentioning

confidence: 97%

“…Recent clinical studies have shown that higher CSFP is associated with higher arterial blood pressure. 7,8 We therefore postulated that widening of retinal veins and the increased vein-to-artery diameter ratio in arterial hypertension is indirectly caused by increased CSFP. Because arterial blood pressure has an effect primarily on the arterial side, but not on the venous side, of the circulation, the association between higher arterial blood pressure and higher CSFP could explain why arterial hypertension is associated with wider retinal veins and an increased retinal vein-to-artery diameter ratio.…”

mentioning

confidence: 99%

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Retinal Vessel Diameter and Estimated Cerebrospinal Fluid Pressure in Arterial Hypertension: The Beijing Eye Study

Jonas

Wang

et al. 2014

American Journal of Hypertension

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Arterial hypertension leads to retinal microvascular abnormalities, including thinning of retinal arteries, widening of retinal veins, and an increase in the retinal vein-to-artery diameter ratio. [1][2][3][4][5][6] The retinal microvascular abnormalities are of clinical importance because they are associated with arterial hypertension-related sequelae, including stroke. 1-6 At a given elasticity of the vessel wall, the vessel diameter depends on the intravasal pressure. Because the central retinal vein passes through the optic nerve and the orbital cerebrospinal fluid space, the blood pressure in the central retinal vein inside of the eye should be at least as high as the orbital cerebrospinal fluid pressure (CSFP) is. Recent clinical studies have shown that higher CSFP is associated with higher arterial blood pressure. 7,8 We therefore postulated that widening of retinal veins and the increased vein-to-artery diameter ratio in arterial hypertension is indirectly caused by increased CSFP. Because arterial blood pressure has an effect primarily on the arterial side, but not on the venous side, of the circulation, the association between higher arterial blood pressure and higher CSFP could explain why arterial hypertension is associated with wider retinal veins and an increased retinal vein-to-artery diameter ratio.

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“…Die beiden Gruppen unterschieden sich nicht hinsichtlich der Glaukomform, des Alters, des Ausgangsdrucks und der präoperativen Tropftherapie voneinander. Eine Erklärung hierfür könnte der geringere translaminäre Druckgradient zwischen zerebrospinaler Flüssigkeit und Augeninnendruck sein[15,17,18]. Berdahl et al[19] führte eine retrospektive Analyse des Liquordrucks bei mehr als 30 000 Individuen mit und ohne Glaukom durch.…”

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