Cerebrospinal fluid and blood lactate concentrations as prognostic biomarkers in dogs with meningoencephalitis of unknown origin

Fuentes, Miriam Portero; Merlo, Elena Martínez de; Pérez, Carmen Gómez; Benito, Miguel Benito; González, M.A. Daza; Fragío, Cristina

doi:10.1016/j.tvjl.2019.105395

Cited by 11 publications

(15 citation statements)

References 25 publications

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“…16,29,30 Information on prognostic factors for MUE is limited. 33,34 However, early detection of progression and therapeutic decision making may be important in the management of the disease and survival time.…”

Section: Discussionmentioning

confidence: 99%

“…Information on prognostic factors for MUE is limited. 33 , 34 However, early detection of progression and therapeutic decision making may be important in the management of the disease and survival time. Although the acquisition of serial MRI is the best option for identifying the progression of MUE, it is not practical owing to the risk of anesthesia and the costs involved.…”

Section: Discussionmentioning

confidence: 99%

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Neurofilament light chain as a biomarker of meningoencephalitis of unknown etiology in dogs

Yun

Koo

Chae

et al. 2021

Veterinary Internal Medicne

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Background: Neurofilament light chain (NfL) is a neuron-specific cytoskeletal protein expressed in axons. Damaged axons of the central nervous system release NfLs into the cerebrospinal fluid (CSF) and the blood. In humans with neurologic diseases, NfL is used as a biomarker.Objectives: To identify the potential of NfL as a supportive tool for the diagnosis, prognosis, and monitoring of meningoencephalitis of unknown etiology (MUE) in dogs.Animals: Twenty-six client-owned healthy dogs, 10 normal Beagle dogs, and 38 client-owned MUE dogs.Methods: Cohort study. The concentrations of NfL in serum and CSF were measured using single-molecule array technology.Results: Median NfL concentration was significantly higher in MUE dogs (serum, 125 pg/mL; CSF, 14 700 pg/mL) than in healthy dogs (serum, 11.8 pg/mL, P < .0001; CSF, 1410 pg/mL, P = .0002). The areas under the receiver operating characteristic curves of serum and CSF NfL concentrations were 0.99 and 0.95, respectively. The cut-off values were 41.5 pg/mL (serum) and 4005 pg/mL (CSF) for differentiating between healthy and MUE dogs, with sensitivities of 89.19% and 90%, respectively, and specificities of 96.97% and 100%, respectively. The NfL concentration showed a significant decrease (pretreatment, 122 pg/mL; posttreatment, 36.6 pg/mL; P = .02) in the good treatment-response group and a significant increase (pretreatment, 292.5 pg/mL; posttreatment, 1880 pg/mL, P = .03) in the poor treatment-response group.Conclusions and Clinical importance: Neurofilament light chain is a potential biomarker for diagnosing MUE and evaluating response to treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Neurofilament light chain as a biomarker of meningoencephalitis of unknown etiology in dogs

Yun

Koo

Chae

et al. 2021

Veterinary Internal Medicne

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“…The cause behind the obstruction is a defect in ureteropelvic-junction, urinary tract obstruction or extra uropathic-lesion. [1][2][3] Uropathy can be an effect of interrupted urine flow in kidney as well as urethra, or bladder, prostate, alterations of retroperitoneum or the vascular system. 4,5 Ultrasound has been used as a main method of detecting hydronephrosis.…”

Section: Introductionmentioning

confidence: 99%

Hydronephrotic Kidney Assessment via Ultrasonography

Das¹,

Daseja²,

.³

et al. 2022

PJMHS

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Objective: To assess hydronephrotic kidney assessment via ultrasonography. Study Design: Prospective study. Place and Duration of Study: Department of Radiology, Chandka Medical College Hospital, Larkana from 1st August 2020 to 31st September/2021. Methodology: Two hundred patients visited for the complaint and suspicion of hydronephrosis and within them 40 patients were diagnosed with hydronephrosis. The both kidneys were examined in the longitudinal as well as transvers planes of scanning using colored Doppler technique in ultrasonography. In older age patients a curved-array transducer having centered frequencies (3-6 MHz) was applied while in case of younger patients’ linear array-transducer was used with high entre frequencies. Results: The age of the patients was between 12-72 years with more elderly patients than youngsters. Most of the patients were males rather than females. Ureteropelvic obstruction in junction, primary megaureter as well as urethral valve involvement was observed in ultrasound imaging of hydronephrotic pediatric kidney. End stage hydronephrosis was presented in adult patients with cortical thining. Conclusion: Ureter and kidney stone appeared to be a common reason of hydronephrosis. Keywords: Hydronephrosis, Ultrasonography, Blockage, Calculi

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“…Several studies have addressed potential prognostic factors for MUO [ 4 , 5 , 6 ] and its aetiology. The main hypothesis is an autoimmune or genetic cause [ 7 , 8 ] that is associated with a triggering factor that leads to the presentation of disease signs in a specific manner and at a given time point [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Role of Leishmania infantum in Meningoencephalitis of Unknown Origin in Dogs from a Canine Leishmaniosis Endemic Area

et al. 2021

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The main hypothesis for the aetiology of meningoencephalitis of unknown origin (MUO) in dogs is an autoimmune or genetic cause that is associated with a triggering event (environmental factors/infectious agents). The aim of this ambispective cohort study was to test for Leishmania infantum infection in the blood and cerebrospinal fluid (CSF) of dogs with MUO in an endemic area of canine leishmaniosis. Dogs with MUO were selected amongst all dogs undergoing blood anti-L. infantum antibody testing (control group). The blood plasma or serum samples from all dogs were analysed for anti- L. infantum antibodies by a quantitative indirect fluorescent assay (IFAT). In dogs with MUO, CSF samples were obtained for analysed by PCR detection of L. infantum DNA. Forty-four percent and 22% of the dogs in the MUO group featured magnetic resonance imaging (MRI) findings and CSF cytology respectively, consistent with L. infantum infection. IFAT, PCR, and histological findings were negative for L. infantum. A significant difference in L. infantum infection prevalence was found between the control and MUO group (p = 0.0022). While it seems unlikely that L. infantum plays a role in the aetiology of MUO, in endemic areas, this pathogen should be included in the differential diagnosis of this neurological disorder.

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Cerebrospinal fluid and blood lactate concentrations as prognostic biomarkers in dogs with meningoencephalitis of unknown origin

Cited by 11 publications

References 25 publications

Neurofilament light chain as a biomarker of meningoencephalitis of unknown etiology in dogs

Neurofilament light chain as a biomarker of meningoencephalitis of unknown etiology in dogs

Hydronephrotic Kidney Assessment via Ultrasonography

Role of Leishmania infantum in Meningoencephalitis of Unknown Origin in Dogs from a Canine Leishmaniosis Endemic Area

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