Cerebral White Matter Lesions, Retinopathy, and Incident Clinical Stroke

Association between retinal vascular measures and brain white matter lesions in schizophrenia

“…Our findings are in accord with previous studies that reported an association between white matter lesions and retinal vascular measures in healthy individuals or other disease conditions; association between white matter lesions and FD (Hilal et al, 2014;McGrory et al, 2019), (Wong et al, 2002a(Wong et al, , 2002b, retinal vascular tortuosity (Kim et al, 2017;Kwa et al, 2002) have been reported. However, unlike previous studies, we did not find a significant relationship between retinal vascular diameter and white matter hypo-intensity (Hilal et al, 2014;Kwa et al, 2002;Mutlu et al, 2016a).…”

Retinopathy as an indicator of silent brain infarction in asymptomatic hypertensive subjects

“…In multivariate analysis, HTR grade 1 showed a marginal significance for the presence of SBI. These results are consistent with a previous report that the higher grade of retinopathy is strongly associated with the risk of subclinical stroke [11,18]. SBI, which is due to occlusive-type microangiopathy of the cerebral vasculature, is well known to have a strong relationship with chronic hypertension [2][3][4][5].…”

Association of MRI Markers of Vascular Brain Injury With Incident Stroke, Mild Cognitive Impairment, Dementia, and Mortality

“…The association of BI and EXT-WMHV with incident stroke is in line with previous findings in other population-based studies,1–6 both in middle-aged,1, 4 and elderly individuals 2, 3, 5, 6. In addition, we found that the continuous quantitative measure of WMHV was not associated with an increased risk of stroke, which could suggest a threshold effect, with WMH being associated with an increased stroke risk only beyond a certain volume.…”